| KCD (13) | Author | Year | Country | Condition | [Registered] Total sample size(T/C); Gender(M/F) | [Analysed] Total sample size(T/C); Gender (M/F) | Age(mean±SD); Duration | Intervention (Regimen) | Comparison (Regimen) | Outcome | Adverse events | Conclusions |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| A00-B99 Certain infectious and parasitic diseases | Chen(4) | 2020 | China | Gastrointestinal dysfunction in patients with sepsis | 25/25; (10/15; 12/13) | 25/25; (10/15; 12/13) | 41.32±13.57;43.17±13.68/NR | Changweishu + routine Western medicine treatment, 7 days | Routine Western medicine treatments(meropenem, noradrenaline, glutamine glue, Bifidobacterium lactis triple-strain tablet) | 1) APACHE II score 2) Gastrointestinal dysfunction score 3) Serum levels of diamine oxidase (DAO) 4) D-lactic acid, inflammatory factors (tumor necrosis factor (TNF)-a 5) Interleukin (IL)-6 6) High-mobility group box 1 (HMGB-1)) 7) The incidence of multiple organ dysfunction syndrome (MODS) and mortality | There were no adverse effects in either group. | The addition of Changweishu to routine Western treatments can improve gastrointestinal function in patients with sepsis and gastrointestinal dysfunction, as well as decreasing the incidence of MODS and mortality and improving patient prognosis. |
| A00-B99 Certain infectious and parasitic diseases | Li | 2019 | China | Uncomplicated gonorrhea | 20/20; NR | 20/20; NR | 28.9±12.4;31.1±11.7/NR | Bazhengsan formula (BZSF, [dedcoction] bid, 10d, [Bathtub] 30min, once daily, 10d) + ceftriaxone(im, once daily, 10d) | Ceftriaxone(im, once daily, 10 days) | 1) Bacteriological cure 2) Clinical response | No severe adverse events | The findings of this study showed that BZSF as an adjunctive therapy to ceftriaxone may be not superior to the ceftriaxone alone for Chinese female patients with uncomplicated gonorrhea after 10 days treatment. |
| A00-B99 Certain infectious and parasitic diseases | Li(2) | 2019 | China | Sepsis | 20/20; (13/7; 11/9) | 20/20; (13/7; 11/9) | 67.1±4.1;65.9±4.2/NR | Acupuncture(EX-B2) + routine treatment, 30 min.once a day,10days | Routine treatment of nasogastric mosapride citrate (5 mg/time, three times a day) and tifidobacterium triple viable capsules (420 mg, twice a day), intravenous infusion of Omeprazole (40 mg, twice a day), rational dose of antibiotics, maintenance treatment of functions of the heart, lung, brain, kidney and other important organs and water electrolyte balance, as well as symptomatic treatment. | 1) The acute physiology and chronic health evaluation (APACHE II) score 2) Intra-abdominal pressure 3) ntragatric residul volume | NR | Acupuncture stimulation of EX-B2 has a good curative effect in improving gastrointestinal dysfunction in sepsis patients. |
| A00-B99 Certain infectious and parasitic diseases | Xing(2) | 2019 | China | Septic acute gastrointestinal injury | 151/151; NR | 151/151; (101/50; 97/54) | 75.5±11.7;75.4±12.2/NR | Traditional Chinese medicine (TCM) bundle therapy(nasal feeding, enteroclysis, CV12, ST36, ST25, ST37, ST39, twice daily for 15 min each time,Shenque point- Fructus evodiae and cinnamon (3 g each) were ground and mixed with vinegar) + conventional treatments, 14 days | Conventional treatment | 1) Mortality within 28 days 2) Clinical indicators of sepsis: D-lac, serum levels of diamine oxidase (DAO), lipopolysaccharides (LPS), motilin (MTL), and tumor necrosis factor (TNF)-α, APACHE II score, sequential organ failure assessment (SOFA) score, MODS score, intra-abdominal pressure, bowel sounds, abdominal circumference, duration of mechanical ventilation, duration of ICU stay, gastrointestinal function (GIF) score | Apart from sepsis-related events leading to mortality, three patients vomited when receiving the decoction. Two patients had ecchymosis after acupuncture. No patient stopped treatment because of adverse events. | TCM bundle therapy in the early stage of sepsis can improve survival and the markers of gastrointestinal function in patients with sepsis associated with AGI. |
| A00-B99 Certain infectious and parasitic diseases | Zheng | 2020 | China | Brain injury in patients with sepsis | 35/35; (16/19; 18/17) | 35/35; (16/19; 18/17) | 57.5±7.9;59.3±8.3/NR | Electroacupuncture therapy(GV20, GV26, 30min, once 12hr, 1week) | Routine western medicine treatment, anti-infective therapy, nerve nutrition,and mechanical ventilation, 1 week | 1) Serum levels of C-reactive protein (CRP), interleukin-6 (IL-6), and neuron-specific enolase (NSE) 2) Montreal Cognitive Assessment (MoCA) scale 3) Glasgow Coma Scale (GCS) score | NR | Electroacupuncture at GV20 and GV26 can effectively improve brain injury and effective rate in SAE patients. |
| A00-B99 Certain infectious and parasitic diseases | Li(4) | 2020 | China | HBeAg-Positive Chronic Hepatitis B Patients | 295/295; NR | 280/280; (207/73; 206/74) | 33.9±10.3; 34.3±10.4/NR | Adefovir dipivoxil (ADV) + Chinese medicine (Tiaogan Jianpi Hexue, Tiaogan Jiedu Huashi), 48 weeks | ADV + CM-placebo | 1) Rates of HBeAg and HBV-DNA loss 2) Routine blood, urine, and stool analyses, electrocardiogram and abdominal B scan | No additional AEs were found in EG. | Combination of CM and ADV therapy demonstrated superior HBeAg clearance compared with ADV monotherapy. The finding indicates that this combination therapy may provide an improved therapeutic effect and safety profifi le |
| A00-B99 Certain infectious and parasitic diseases | Yang(3) | 2019 | China | Helicobacter pylori infection | 129/96/112/118; (47/82; 47/49; 51/61; 44/74) | 129/96/112/118; (47/82; 47/49; 51/61; 44/74) | 49±12;46±12;47±13;46±13/NR | 1) Jinghuaweikang capsules + (3) 2) Jinghuaweikang capsules + (4) | 3) Esomeprazole(20 mg, twice a day, 14days) + pectin bismuth(200 mg, three times a day) + amoxicillin(1000 mg, twice day, 14days) + elarithromycin(500 mg, twice a day, 14days) 4) Esomeprazole(20 mg, twice a day, 14days) + bismuth pectin (200 mg, three times a day) + amoxicillin(1 000 mg, twice a day, 14days) + furazolidone(100 mg, twice a day, 14days) | 1) Symptoms (abdominal Pain, acid reflux, abdominal distension) 2) H.Pylori test - 13C or 14C | NR | Jinghuaweikang capsules can improve the eradication rate of Helicobacter pylori,and improve the symptoms of patients． |
| A00-B99 Certain infectious and parasitic diseases | Zhu | 2019 | China | Herpes zoster | 30/30; (18/12; 16/14) | 30/30; (18/12; 16/14) | 47±13;44±15/ 3.9±1.6;3.7±1.7(d) | Thumb-tack acupuncture + valaciclovir hydrochloride dispersible tablets (0.3 g, bid) + mecobalamin tablets (0.5 mg, tid) + Vit B1 (10 mg, tid) | Oral valaciclovir hydrochloride dispersible tablets (0.3 g per time, twice per day), mecobalamin tablets (0.5 mg per time, three times a day) and vitamin B1 (10 mg per time, three times a day) | 1) The index of herpetic evaluation (stopping time of herpes, scarring time, decrustation time) 2) Visual analogue scale (VAS) 3) Serum immune-related factors (IgG, IgM, IgA) 4) Serum inflammatory factors (IL-4, IL-17, TNF-α, TGF-β1) | NR | The thumb-tack acupuncture with surrounding needling method plus medication have the advantages of rapid onset and analgesic effect for HZ of stagnated heat in liver meridian type, which could also improve serum immune-related factors and reduce inflammatory reaction. |
| C00-D48 Neopla | Brinkhaus | 2019 | Germany | Chemotherapy with breast cancer | 75/75; NR | 54/51; NR | 150명(처음참가자) 기준: 51.4 ± 10.4; 50.6 ± 9.5/ nr | Acupuncture [Nausea, vomiting and gastrointestinal symptoms] PC6, ST 36, ST 44, CV10, CV12 [Polyneuropathy] ST36, ST42, LI11, LI10, Extra Points Baxie and Bafeng [Articular and muscle pain] LI10, LI11, ST36, GB 34, GB 39 [Cancer-related fatigue] GV20, ST36, LI 10, CV 4 and 6 [Depression and anxiety] PC6, HE7, HE 6, and KID4 | Standard care | 1) Disease-specific quality of life (FACT-B) 2) Complaintspecific FACIT-fatigue 3) FACT-GOG-NTX 4) Generic health-related quality of life by Short-Form (SF)-12 5) Patient satisfaction with acupuncture treatment | NR | Breast cancer patients receiving prophylactic acupuncture during chemotherapy did not show better quality of life in the questionnaires in contrast to the reported positive effects in the qualitative interviews. Coping strategies for cancer appear to be important. |
| C00-D48 Neopla | Chen | 2020 | China | Non-small Cell Lung Cancer | 34/34; (16/18; 14/20) | 34/34; (16/18; 14/20) | 53.1±5.2;54.2±4.9/NR | Gufei Xiaoji decoction, once a day till end of chemotherapy + conventional chemotherapy | Conventional chemotherapy | 1) Expression levels of PI3K)AKT and VEGF 2) Clinical efficacy 3) Symptom scores 4) Incidence of adverse reactions | NR | Gufei Xiaoji decoction may improve the effectiveness of chemotherapy on patients, possibly by inhibiting the expression of VEGF through the PI3K/AKT signaling pathway. In addition, it does not increase the incidence of adverse reactions. It is safe and worthy of clinical application. |
| C00-D48 Neopla | Chen(2) | 2020 | China | Lung cancer patients undergoing thoracoscopic pulmonary resection | 44/44 ; NR | 40/40; (23/17; 22/18) | 56.0±3.7;55.8±3.2/106.28±18.40;111.95±13.60 | Transcutaneous electrical acupoint stimulation (TEAS) + general anesthesia acupoint: Hegu (LI 4), Neiguan (PC 6), Houxi (SI 3), Zhigou (TE 6) acupoints. electrical stimulation (10–15 mA) for 30 minutes before anesthetic induction, continuous stimulation (30 mA) throughout the surgical procedure, and intermittent stimulations (10–15 mA) for 30 minutes each at six, 24, and 48 hours after the surgery. | Sham TEAS + general anesthesia(4 mA stimulation before and after the surgery in the same manner as mentioned on intervention group) | 1) Postoperative Pain levels: visual analogue scale (VAS) 2) Bispectral index (BIS) 3) Observer’s Assessment of Alertness)Sedation (OAAS) score 4) Sufentanil consumption during postoperative patient-controlled intravenous analgesia (PCIA 5) Number of total and effective attempts of PCIA pump use) 6) Incidence of postoperative nausea and vomiting(PONV) | NR | TEAS could be a feasible approach for sedation and postoperative analgesia in thoracoscopic pulmonary resection |
| C00-D48 Neopla | Dilaveri | 2020 | USA | Breast Cancer Patients Undergoing Reconstructive Surgery | 21/21; NR | 19/21; NR | 48.89±10.89;50.95±6.93/NR | Acupuncture + massage(20 min at each session), 3 d | Massage(20 min at each session), 3 d | 1) Stress, anxiety, relaxation, nausea, fatigue, Pain, mood - (VAS scores 0–10) 2) Patient satisfaction: Was It Worth It (WIWI) survey | Five participants reported adverse events as being related to the assigned treatment: headaches (Massage-Only Group, n = 2), neck soreness (Massage-Only Group, n = 1), nausea (Massage-Only Group, n = 1), and nausea and headache (Massage+Acupuncture Group, n = 1 for each). All adverse events were reported as mild. | No additive beneficial effects were observed with addition of acupuncture to massage for pain, anxiety, relaxation, nausea, fatigue, and mood. Combined massage and acupuncture was not as effective in reducing stress as massage alone, although both groups had significant stress reduction. These findings indicate a need for larger studies to explore these therapies further |
| C00-D48 Neopla | Dymackova | 2020 | Czech Republic | Acute toxicity during and after head and neck cancer radiotherapy | 15/15; (10/5; 12/3) | 15/15; (10/5; 12/3) | median 52;60 | Standard of care + acupuncture(2 times/week, during the RT, possible to continue in acupuncture for additional 1-2 months after RT in weekly or fortnightly regimen according to patient's needs and severity of toxicity) | Standard of care | 1) Toxicity evaluation: Acute Pain, Nausea, taste perception and salivation | None | In this interim analysis, acupuncture leads to lower pain andfaster disappearance of skin and mucosal toxicity after (chemo)radiotherapy of head and neck cancer. Description and validation of acupuncture using scientific approaches will further enhance acceptance of this method by both patients and health care providers |
| C00-D48 Neopla | Eberl | 2020 | Netherlands | Colonoscopy | 51/51/51; (20/31; 17/34; 23/28) | 51/51/51; (20/31; 17/34; 23/28) | 62;65;63/47;46;43 | 1) Electroacupuncture (ST36, PC6, LI4) | 2) Sham-acupuncture (PC6, ST36, LI4, 1 cm distal and lateral to the real point) 3) Placebo-acupuncture (placebo needles at the same points as sham acupuncture) | 1) Total dosage of propofol 2) Patients’ and endoscopists’ satisfaction | The number of cardiorespiratory adverse events (data not shown), and also haemodynamic parameters during recovery (HR, NIBP, SpO2 and Aldrete score) (data not shown), were not significantly different between the three groups. | For colonoscopy, the applied mode of EA did not show any propofol-sparing sedative effect compared with sham or placebo acupuncture |
| C00-D48 Neopla | Fujita | 2019 | Japan | Colorectal cancer | 10/10; NR | 9/8; (2/8; 5/3) | 69;75/NR | Tsumura Daikenchuto Extract Granules (DKT, TJ-100, 2 days prior to surgery up to 12 weeks following surgery) | non-administration | 1) Body weight gain 2) Gastrointestinal Symptom Rating Scale (GSRS) 3) Blood biochemical factors. | No obvious adverse events were observed in any of the cases | It is suggested that TJ-100 can be safely administered in the perioperative period for cases undergoing colorectal cancer surgery, potentially preventing weight loss during the early postoperative period. |
| C00-D48 Neopla | Garcia | 2019 | USA | Radiation-Induced Xerostomia Among Patients With Head and Neck Cancer | [Fudan] 79/81/80; (55/16; 55/19; 58/18) [MD Anderson] 53/53/53; (39/8; 43/7; 31/9) | [Fudan] 66/71/75; NR [MD Anderson] 46/44/37; NR | Ⅰ. Fudan 46.3± 11.5; 48.3± 11.1; 46.4± 10.4 Ⅱ. MD Anderson 57.5± 9.4; 57.7± 9.7; 58.7± 9.6 | 1) Standard care control (SCC) with true acupuncture (TA) 2) Standard care control (SCC) with sham acupuncture (SA), 3 times/week, 6-7 weeks | Standard care control (SCC) | 1) RIX: Xerostomia Questionnaire 2) Incidence of clinically significant xerostomia (score >30) 3) Salivary flow, quality of life 4) Salivary constituents 5) Role of baseline expectancy related to acupuncture | 1 adverse event related to acupuncture (pain from needling at 1 site in the ear). | This randomized clinical trial found that TA resulted in significantly fewer and less severe RIX symptoms 1 year after treatment vs SCC. However, further studies are needed to confirm clinical relevance and generalizability of this finding and to evaluate inconsistencies in response to sham acupuncture between patients in the United States and China. |
| C00-D48 Neopla | Gong | 2020 | China | Middle and Advanced Non-Small Cell Lung Cancer | 63/63; (40/23; 38/25) | 63/63; (40/23; 38/25) | 56.27±13.04;56.31±12.69/NR | Buyuan decoction(once a day, 30 days) + Guizhi Fuling decoction(once a day, 30 days) + GP chemotherapy, | GP chemotherapy | 1) Levels of T lymphocyte subsets CD3+, CD4+, CD8+and the CD4+)CD8+ 2) Levels of immunoglobulin IgA, IgG and IgM | NR | Buyuan decoction and Guizhi Fuling pills could improve the immune function, and make a significant curative effect on middle and advanced NSCLC patients. |
| C00-D48 Neopla | Gu | 2020 | China | After Hyperthermic intraperitoneal chemotherapy,HIPEC | 60/60; (26/34; 25/35) | 60/60; (26/34; 25/35) | 58.5±11.3;61.1±12.1/NR | warming needling technique(1hbefore HIPEC,once a day,3days)+(Zusanli(ST36), Sanyinjiao (SP6) and Yinlingquan (SP9)) even-needing technique of acupuncture (30min)+(Neiguan(PC6)) Intravenous injection with Ondansetron(30 min before HIPEC) | Intravenous injection with Ondansetron(30 min before HIPEC,once a day,3days) | 1) Change in gastrointestinal reaction (nausea,vomiting,abdominal distention, diarrhea, total bilirubin(TB), alanine aminotransferase(ALT), alkaline phosphatase(ALP), KPS score) 2) Average hospitalization length of stay | NR | The warming needling technique of acupuncture and moxibustion alleviates the gastrointestinal reaction, improves KPS score and reduces the hospitalization length of stay in HIPEC patients after the surgery of colon cancer and differentiated as the spleen and stomach deficiency in traditional Chinese medicine. |
| C00-D48 Neopla | He | 2020 | China | Gastric cancer | 184; NR | 43/45/46/43; (36/7; 33/12; 34/12; 35/8) | 60.7±11.7; 61.0±10.6; 58.8±9.9; 63.3±10.7/NR | 1) Low-frequency electrical stimulation (ST36, ST37, ST39, SP6), 30 min, once daily from 1day after the operation to first postoperative flatus 2) Low-frequency electrical acupoint stimulation on the basis of the FTS treatmen | 3) conventional treatment: pre-surgical mechanical bowel preparation, post- surgical fasting,and indweling abdominal drainage tube 4) Fast track surgery treatment: reoperative education,preoperative nutritional support,early oral feeding,early removal of abdominal drainage tube | 1) Levels of white blood cells(WBC) , neutrophils (N) , Oreactive protein (CRP) , interleukin-6 (IL-6) and tumor necrosis factor-a (TNF-a) 2) First postoperative flatus and defecation time | NR | FTS combined with LEAS is superior to simple FTS or LEAS treatment in shortening the first flatus and defecation time and promoting the recovery of gastrointestinal motility function in patients undergoing radical gastrectomy, which may be associated with its effect in alleviating postoperative inflammatory responses. |
| C00-D48 Neopla | Huang | 2019 | China | Patient's recovery after laparoscopic colorectal cancer resection | 29/28; (12/17; 17/11) | 29/28; (12/17; 17/11) | 58.59;60.57/NR | Transcutaneous electrical acupoint stimulation (TEAS, bilateral ST 36 at 30 min before anesthesia to the end of surgery)+ Perioperative anesthesia management + postoperative patient-controlled intravenous analgesia (PCIA) | Perioperative anesthesia management + postoperative patient-controlled intravenous analgesia (PCIA) | 1) The amount of sufentanil and remifentanil used 2) Pain 3) postoperative anal exhaust time, postoperative feeding time, postoperative first ambulation time, postoperative hospital stay length | NR | TEAS can promote the recovery of postoperative gastrointestinal function and reduce he pain intensity 48 h after surgery, thus satisfying the need of early postoperative analgesia. |
| C00-D48 Neopla | Huang | 2019 | China | Lung cancer after operation | 30/30; (18/12; 21/9) | 30/30; (18/12; 21/9) | median 56;58, range37-73;40-75/NR | Zilongjin Tablets ((4 tablets, 3 times/d, since 3days after operation,12days )+ routine supportive treatment | Routine supportive treatment | 1) Indexes of immunoglobulin (IgA, IgG, IgM) 2) T lymphocyte subsets (CD3+, CD4+, CD8+, CD4+)CD8+) 3) NK cells | NR | Patients with lung cancer have immunosuppressive status in the early postoperative period. Zilongjin Tablets can improve the postoperative humoral immunity and cellular immunity of patients with lung cancer, promote the recovery of immune function and enhance their anti-tumor ability. |
| C00-D48 Neopla | Jiang | 2019 | China | Radical thyroidectomy | 31/31; (7/24; 6/25) | 31/31; (7/24; 6/25) | 44±11;47±9/NR | Auricular point pressing with magnetic beads(TF4), 30 min before anesthesia + Transcutaneous electrical acupoint stimulation(LI 4, PC6) | Sham auricular point ,30 min before anesthesia | 1) Visual analogue scale for anxiety (VAS-A) score 2) Total intraoperative dosages of sufentanil, remifentanil and propofol 3) Numerical rating scale (NRS) score | NR | Acupoint stimulation can improve the preoperative anxiety in patients with radical thyroidectomy, reduce the intraoperative anesthetic dosage and postoperative pain, advance the time of anal exhaust and getting out of bed, improve the quality of postoperative recovery and enhance the recovery process |
| C00-D48 Neopla | Li | 2020 | China | Breast Cancer and Bone Metastasis | 21/21; NR | 21/21; NR | 60.44±11.45;59.28±12.37/NR | Yanghe decoction 200ml/time, bid, 6months + Conventional chemotherapy + zoledronic acid 4mg | Conventional chemotherapy measures + zoledronic acid 4mg in 100ml injection >15mins, 6 months | 1) The expressions of CXCL12, CXCR and VEGF 2) Therapeutic effects on bone metastasis | NR | Yanghe decoction could improve the treatment expectation of breast cancer, possibly due to the reduction of VEGF secretion by CXCL12/CXCR4. In addition, Yanghe decoction did not increase the incidence of adverse reactions. It is worthy of popularization and application. |
| C00-D48 Neopla | Li(11) | 2019 | China | Colon cancer Stage Ⅲ | 35/37; (19/16; 21/16) | 35/37; (19/16; 21/16) | NR/NR | Banxia Xiexin decoction (MBXD, 14d/cycle, 4 cycles) + chemotherapy(3 cycles) | chemotherapy | 1) The adverse reactions 2) Symptom and life quality 3) Disease-free survival (DFS) | NR | MBXD combined with chemotherapy may significantly relieve clinical symptoms, reduce chemotherapy associated adverse effects, improve life quality, and prolong DFS of patients with stage Ⅲ colon cancer (cold-heat complicated pattern). |
| C00-D48 Neopla | Li(5) | 2020 | China | Postoperative Constipation for Patients Undergoing Brain Tumor Surgery | 44/45/46; NR | 44/45/46; NR | NR | 1) Acupuncture(ST25, once a day, 7 days) 2) Electroacupuncture(ST25, 15 Hz, and the wave width was 20 μs, once a day, 7 days) | No treatment | 1) Rome III Diagnostic Criteria 2) Cleveland Clinic Constipation Score 3) Symptom assessment 4) Patient Assessment of Constipation 5) Quality of Life questionnaire 6) Self-Rating Anxiety Scale 7) Self-Rating Depression Scale | NR | Acupuncture and EA are novel adjuvant therapies to treat constipation. |
| C00-D48 Neopla | Liang | 2019 | China | Prewarming effect | 40/40; (13/17; 14/16) | 40/40; (13/17; 14/16) | 60.3±9.7/58.8±14.3; NA | Transcutaneous acupoint electrical stimulation (GV14, GV4, 30 min, 2 Hz/100 Hz, 20-30 mA) | Sheet electrodes of EA stimulator(GV14, GV 4 without electrical current transmission) | 1) Anesthetic depth (bispectral index(BIS, between 45-60), endtidal carbon dioxide tension(PETCO2, between 30-45 mmHg) | NR | TAES preconditioning of GV14 and GV4 can produce prewarming effect before anesthesia,shorten the awaking time and reduce the incidence of chills in the recovery period in patients undergoing elective video-assisted thoracoscopic lobectomy. |
| C00-D48 Neopla | Lin | 2019 | China | Non-small cell lung cancer | 30/30; (17/13; 14/16) | 30/30; (17/13; 14/16) | 61.6±8.6;63.4±6.0/NR | Fire needle stimulation(BL17, BL19, once a day, 7days) + chemotherapy simultaneously | Paclitaxel combined with cisplatin(TP) or gemcitabine plus cisplatin(GP) of chemotherapy | 1) Karnofsky performanee status (KPS) score | NR | Fire needle stimulation at Sihua acupoints improves the function of Th1 cells, and reduces the function of Th2 cells. As a result, the balance between Th1 and Th2 has been modified and the deterioration degree of the performance status been alleviated in the patients after chemotherapy |
| C00-D48 Neopla | Liu | 2020 | China | Metastatic colorectal cancer | 160/160; (87/73; 111/49) | 160/160; (87/73; 111/49) | 63.89±10.11;62.19±7.84/NR | Huangci Granule(12 g, twice a day until disease progression, death, intolerable toxicity or up to 6 months) + chemotherpy + BV/CET | Placebo + Chemotherapy + BV/CET | 1) Progression-free survival (PFS) 2) Quality of life and safety | No serious adverse events occurred in either group. The incidence of grade 3 or higher treatment-related adverse events (TRAEs) in TCM group was lower than that in control group. | Huangci Granule combined with chemotherapy and CET or BV can prolong the PFS of mCRC, improve the quality of life, reduce adverse reactions, and have good safety. |
| C00-D48 Neopla | Lu(2) | 2019 | China | Colorectal Cancer Undergoing Chemotherapy | 45/45; NR | 43/44; (26/17; 30/14) | 55.60±11.23;54.63±11.88/NR | Baduanjin qigong(16: 00 to 17: 00 every day, 20–40 min/session, 5 sessions/week, 24 w) | Routine care | 1) Brief Fatigue Inventory (BFI) 2) Karnofsky Performance Status (KPS) 3) Pittsburgh Sleep Quality Index (PSQI) | NR | Baduanjin qigong exercise can relieve CRF in patients with colorectal cancer undergoing chemotherapy and can improve their physical activity level and their quality of sleep. |
| C00-D48 Neopla | Okabe | 2019 | Japan | Gastric cancer | 55/55; NR | 55/55; (37/18; 37/18) | 65;64/ | Hochu-ekki-to (TJ-41) + S-1, 1 year | S-1 | 1) Completion rate of S-1 2) Relative dose intensity 3) Relapse-free survival (RFS) 4) Overall survival (OS) | None | TJ-41 does not increase relative dose and completion rate of S-1 significantly. J-41 may reduce toxic effects, but our findings do not support routine use of TJ-41 after gastrectomy. |
| C00-D48 Neopla | Peoples | 2019 | USA | Chemotherapy-induced nausea (CIN) for breast cancer | 81/80/81; NR | 75/75/76; NR | 52.6; 53.2; 53.2/NR | 1) Acupressure bands + expectancy-enhancing material(i.e., expectancy-enhancing handout concerning acupressure bands and expectancy-enhancing relaxation MP3 recording) 2) Acupressure bands and expectancyneutral material (i.e., expectancy-neutral handout concerning acupressure bands and expectancy-neutral relaxation MP3 recording), | Expectancy-neutral handout | 1) Peak CIN | No serious study-related adverse events were reported. | In breast cancer patients undergoing chemotherapy and having high CIN expectation, acupressure bands combined with a relaxation recording were effective in reducing CIN for patients who received doxorubicin or had high anxiety. |
| C00-D48 Neopla | Qi(2) | 2019 | China | Chemotherapy-induced thrombocytopenia in nonsmall cell lung cancer and gastric cancer | 70/70; (51/19; 51/19) | 70/70; (51/19; 51/19) | 63.23±7.83;63.50±10.41/NR | Xiaoaiping injections(1 dose/day, 10 d) + chemotherapy | Chemotherapy | 1) Platelet count 2) Safety measurements | Gastrointestinal bleeding: Control group(1) | In conclusion, Xiaoaiping injections may provide a safe and effective option for CIT in patients with NSCLC. |
| C00-D48 Neopla | Saraswati | 2019 | Indonesia | Cervical Squamous-Cell Carcinoma | 28/25; NR | 21/16; NR | 48.09; 48.75/NR | Chemotherapy+ Electroacupuncture (EA, ST 36, 1day after each cehmotherapy cycle) | Chemotherapy | 1) Natural-killer(NK) cells and tumor size 2) Pain, nausea, vomiting, appetite. | None | Patients with cervical SCC at stages IIb–IIIb, who received 4 cycles of chemotherapy using 50 mg/m2/week of cisplatin and EA at ST 36, had increased NK-cell percentages in their peripheral blood and had reductions in their cervical tumors. |
| C00-D48 Neopla | Su | 2020 | China | Digestive tract reactions caused by chemotherapy | 105/105; (60 /45; 55 /50) | 105/105; (60 /45; 55 /50) | 57.23±15.46;59.4±15.79 | Tropisetron plus dexamethasone /methylprednisolone + herbal external application(one day after the chemotherapy, 1 week) | Tropisetron+Dexamethasone /Methylprednisolone + Placebo | 1) Nausea, abdominal distension, abdominal Pain, vomiting, diarrhea and other digestive tract reactions 2) Nausea, abdominal distension, abdominal Pain, vomiting, diarrhea and other digestive tract reactions | NR | The application of TCM external therapy can reduce the incidence of gastrointestinal reactions in patients receiving platinum-based chemotherapy， significantly relieve nausea， abdominal distension and other discomforts， and improve the symptoms and signs of TCM syndromes in cancer patients after chemotherapy |
| C00-D48 Neopla | Sun | 2020 | China | Non-small cell lung cancer stage IIIb/IV | 225/225; NR | 225/225; NR | NR | Cryoablation(2 weeks) + TCM formula(bid, 28 days after cryoablation, 28days) | Chemotherapy, 4 cycles | 1) Overall survival 2) Progression-free survival 3) Objective response rate 4) Quality of life | NR | NR |
| C00-D48 Neopla | Vallim | 2019 | Brazil | Breast cancer undergoing chemotherapy | 27/27; NR | 27/27; NR | 51; 56/ nr | Auricular acupressure(Shen men, kidney, stomach, cardia, brainstem, endocrine, 12 weeks) | Micropore application onto the auricle (outer ear) | 1) Quality of Life: Core 30 and the Quality of Life Questionnaire- Breast Cancer BR-23 instruments | None | Auricular acupressure has proven to be a safe, effective, low cost method with no side effects and easily applicable by trained nurses. It may be recommended as complementary therapy in treating breast cancer to improve the quality of life of these women. |
| C00-D48 Neopla | Wakasugi | 2020 | Japan | Colorectal cancer patients undergoing surgery with the potential risk of postoperative ileus | 16/16; (10/6; 10/6) | 16/16; (10/6; 10/6) | 68;68/NR | Daikenchuto (DKT, 15g from 2 weeks before surgery to the preoperative day, and from the postoperative day (POD) 2 to POD 28) + standard care | Standard care | 1) Perioperative gastrointestinal symptoms 2) Perioperative complications | There were no adverse events thought to be related to DKT. | DKT could potentially inhibit diarrhea and reduce the number of bowel movements per day and the sensation of incomplete bowel evacuation after colorectal surgery. Thus, the perioperative use of DKT may be safe for colorectal cancer patients with abdominal pain and distention, who undergo surgery. |
| C00-D48 Neopla | Wang(3) | 2020 | China | Lung Adenocarcinoma after Radical Surgery | 116/117; NR | 114/115; (57/57; 61/54) | 59.4±7.4;59.6±7.5/NR | Chinese herbal medicine formulas (CHMFs) + chemotherapy(ACT) | Placebo + ACT | 1) Chemotherapy-related toxic, side effects 2) Disease-free survival (DFS), overall survival (OS) | NR | For patients with LAC, ACT combined with CHMF after radical surgery can prolong the DFS time especially in the early stage, and reduces the chemotherapy-related toxic and side effects. |
| C00-D48 Neopla | Watanabe | 2020 | Japan | Hand-foot syndrome using Capecitabine for colorectal cancer | 12/10; (5/7; 4/6) | 12/10; (5/7; 4/6) | 64.8±6.5;67.5±11.6/NR | TJ-28 (7500 mg/day, tid) + Capecitabine(eight 3-week cycles of 2500 mg/m2 per day, 8 cycles) | Pyridoxine(60 mg/day) + Capecitabine | 1) Grade ≥2 HFS rate 2) Time to the observation of grade ≥ 2 HFS 3) Time to the disappearance of HFS 4) Incidence of adverse events | The rates of these hematological and clinical adverse events did not differ markedly between the TJ-28 and pyridoxine groups. | Capecitabine-associated HFS was not markedly prevented by TJ-28 compared with pyridoxine. However, TJ-28 might support the continuation of chemotherapy with capecitabine. Further studies are warranted to clarify the benefits of TJ-28. |
| C00-D48 Neopla | Xiao(2) | 2020 | China | Rectal cancer after operation | 30/30; NR | 30/30; NR | NR | XELOX (oxaliplatin + capecitabine) chemotherapy + tonifying Qi and nourishing Yin prescription, 150ml, bid, 6w | XELOX | 1) TCM syndrome evaluation 2) Tumor marker index level 3) Toxicity side effects | NR | Tonifying Qi and nourishing Yin prescription for reducing phlegm can improve the efficacy of TCM symptoms based on combined chemotherapy after Colorectal cancer surgery, selectively reduce the toxicity side effects of patients, and decrease the level of tumor marker CEA. |
| C00-D48 Neopla | Yamazaki | 2019 | Japan | Chemotherapy by FOLFIRI.3 regimen for colorectal cancer | 14/15; (8/6; 8/7) | 14/15; (8/6; 8/7) | 56.5;57/NR | Hangeshashinto (TJ‐14, 7.5 g/day, tid) | Alkalization(sodium bicarbonate, 1.8 g/day; ursodeoxycholic acid, 300 mg/day) | 1) Incident of late‐onset diarrhoea 2) Response rate(Response Evaluation Criteria in Solid Tumors guidelines ver.1)1) 3) Medication compliance with the test drugs 4) Incidence of adverse events other than diarrhoea 5) Frequency of taking antidiarrhoeal drugs | There was no statistically significant difference in other adverse events or in response to FOLFIRI.3 between the groups | This pilot trial suggests that TJ‐14 is a promising alternative treatment option to reduce FOLFIRI.3‐induced late‐onset diarrhoea, although additional clinical study with a larger number of patients is necessary to confirm these results. |
| C00-D48 Neopla | Yoon | 2019 | Korea | Sleep in breast cancer patients undergoing chemotherapy | 23/23; NR | 20/21; NR | NR/NR | Auricular acupressure(Shenmen, heart, anterior lobe, occiput, 6/w, 6w) | Placebo point acupressure(four points of Helix located in the auricle) | 1) Pittsburgh sleep quality index scores (PSQI-K) 2) Sleep time, sleep efficiency, sleep latency, or number of times awakened during sleep 3) Blood cytokines and cortisol | None | Sixweeks of auricular therapy using vaccaria seeds effectively reduced cytokine levels and improvements in sleep quality were similar to those acquired using auricular acupuncture. In contrast to auricular acupuncture, auricular therapy is noninvasive, simple, and safe to apply without causing pain. |
| C00-D48 Neopla | Yuan | 2020 | China | Advanced non-small cell lung cancer | 65/65; NR | 65/65; (50/15; 46/19) | 63.35±8.61; 61.21±9.41/NR | Bufei Huayu Decoction + gefitinib, 30d | Gefitinib | 1) The clinical efficacy 2) coagulation indexes 3) prognostic difference and incidence of adverse drug reactions | No serious adverse reactions. The main adverse reaction was the elevated ALT level. No significant difference in ALT level was found in both groups before treatment (P >0.05). | Bufei Huayu Decoction combined with gefitinib in the treatment of advanced non-small cell lung cancer has a significant effect, can effectively regulate coagulation dysfunction, reduce the risk of thrombosis, improve the long-term prognosis of patients, and has good safety. |
| C00-D48 Neopla | Zhang(3) | 2020 | China | Chemotherapy-induced cognitive impairment in breast cancer | 46/47; NR | 45/47; NR | 47.9±9.7;47.9±10.6/NR | Electroacupuncture trigeminal nerve stimulation + body acupuncture (EA/TNS + BA) body acupoints: Shenmen (HT7), Hegu (LI4), Waiguan (TE5), Zusanli (ST36), Fenglong (ST40) and Sanyinjiao (SP6) in two sides, and Zhongwan (CV12), Guanyuan (CV4), and Shuigou (GV26) in midline. electrical stimulation: six pairs of the forehead acupoints with positive (+) and negative (-) electrode cord connection as follows: Baihui (GV20, +) and Yintang (EX-HN3, -), left Sishencong (EX-HN1, -) and Toulinqi (GB15, +), right Sishencong (EX-HN1, -) and Toulinqi (GB15, +), bilateral Shuaigu (GB8, L+, R-), bilateral Taiyang (EX-HN5, L+, R-), and bilateral Touwei (ST8, L+, R-). 2 sessions per week over 8 weeks | Minimum acupuncture stimulation(bilateral: BL17, LI10, BL59) + Electrical stimulation(bilateral BL17) | 1) Montreal Cognitive Assessment (MoCA) 2) Attentional function and working memory: Digit span test 3) The quality of life and multiple functional assessments | The EA/TNS + BA group had significantly fewer incidents of diarrhea (P = 0.037), tenseness (P = 0.030), worrisome (P = 0.018), and irritation (P = 0.040) reported at Week 4, and headache (P = 0.042) and tinnitus (P = 0.026) reported at Week 8 than MAS group. | These results suggest that EA/ TNS + BA may have particular benefits in reducing chemotherapy-induced working memory impairment and the incidence of certain digestive, neurological, and distress-related symptoms. It could serve as an effective intervention for breast cancer patients under and post chemotherapy |
| C00-D48 Neopla | Zhang(6) | 2019 | China | Hepatocellular Carcinoma Who Have Undergone Surgery | 262; NR | 90/90; (78/12; 71/19) | 56.74±8.43;55.24±10.83/3.91±1.31;3.70±1.16 | Ganji Formulation (GF, 12 g, bid, 6 months) | Placebo | 1) Overall survival (OS) 2) Disease-free survival (DFS) or time to disease progression (TTP) | Fifty-one of the treatment group and 47 of the control group had AEs, diarrhea, abdominal pain, dyspepsia, and nausea., normal complete blood counts. | GF could improve ostoperative cumulative survival and prolong the TTP. |
| C00-D48 Neopla | Zhang | 2019 | China | Renal anemia | 30/30; (16/14; 12/18) | 30/30; (16/14; 12/18) | 51.4±10.1;51.4±9.4/NR | Qingshen Granules (3 times/day,12weeks)+ routine treatment | Routine treatment | 1) TCM syndrome 2) Serum creatinine (Scr) 3) Glomerular filtration rate (eGFR) 4) Hemoglobin (HGB) 5) Hematocrit (HCT) 6) Red blood cell (RBC) count 7) Interleukin-6 (IL-6) 8) Hypersensitive C-reactive protein (hs-CRP) 9) Ferritin growth differentiation factor-15(GDF-15) 10) Serum iron (SI) 11) Total iron binding capacity (TIBC) 12) Transferrin saturation (TAST) 13) Soluble transferrin receptor (sTfR) 14) Ferritin levels | NR | Qingshen granules can effectively improve renal anemia in patients with damp-heat syndrome possibly by improving iron metabolism through alleviation of inflammation and reduction of hepcidine level. |
| E00-E90 Endocrine, nutritional and metabolic diseases | Altutunji | 2019 | China | Polycystic ovary syndrome undergoing in-vitro fertilisation | 33/69; NR | 33/69; NR | NR | Follicular phase acupuncture(LIV 3, SP6, SP 8, ST 36, SP 10, ST 29, LI 14, Ren 04) | No treatment | 1) Follicular anti-mullerian hormone in serum | NR | Follicular phase acupuncture was found to have a positive effect for polycystic ovary syndrome patients undergoing in-vitro fertilisation, but it had no effect on anti-mullerian hormone concentrations. |
| E00-E90 Endocrine, nutritional and metabolic diseases | Anwar | 2014 | Pakistan | Diabetic Peripheral Neuropathy | 62/52/50; NR | 62/52/50; NR | 51.54±10.46; 49.38±10.56; 51.70±11.43/(nr) | 1) Laser acupuncture, twice a week, 8 weeks 2) Amitryptaline, 25 mg/day, 14days, 50 mg/day, 6w | Standard of care + sham points, 7-10 mm away from the selected acupoints, twice a week, 8 weeks | 1) Visual Analogue Score 2) Activity of Daily Life 3) Hospital Anxiety and Depression Scale | Laser: no side effect Adverse events in the form of intolerance were reported in some patients. | The mean score in our study reveals that laser acupuncture shows better outcomes in improvement of pain relief, depression, anxiety and daily life activities compared to amitriptyline in patients of diabetic neuropathy. |
| E00-E90 Endocrine, nutritional and metabolic diseases | Chao | 2019 | USA | Painful diabetic neuropathy | 14/12/14; (7/7; 5/7; 8/6) | 14/1/14; (7/7; 5/7; 8/6) | 61.0 ± 9.8; 55.4 ± 11.1; 60.7 ± 11.8/ nr | 1) Usual care+ acupuncture(SP10, LU7, KI6, once weekly, 12weeks) 2) Usual care+ acupuncture(SP10, LU7, KI6, twice weekly, 12weeks) | Usual care | 1) Weekly Pain intensity (NRS) 2) Norfolk Quality of Life Questionnaire–Diabetic Neuropathy (QOL-DN) 3) National Institutes of Health PROMIS form | Out of 263 treatments, 15 side effects were reported: pain (8), swelling (2), numbness (2), nausea (1), cramp (1), palpitation in left arm (1). All were mild and did not require additional intervention. No serious adverse events were reported. | Group acupuncture is feasible and acceptable among linguistically and racially diverse safety net patients. Findings suggest clinically relevant reduction in pain from PDN and quality of life improvements associated with acupuncture, with no differences based on frequency. |
| E00-E90 Endocrine, nutritional and metabolic diseases | Deng(2) | 2019 | China | Polycystic Ovary Syndrome | 38/40/39; NR | 35/36/39; NR | 27.5±3.4;27.2±3.5;26.7±6.4/NR | 1) Dingkun Pill (DKP, 7g, qd) 2) Diane-35, 1T, qd 3) DKP + Diane-35, 21d, 7 day washout period, 3 cycles | 1) Oral glucose tolerance tests (OGTT) 2) Homeostasis model assessment for insulin resistance (HOMA-IR) 3) Quantitative insulin sensitivity check index (QUICKI) | No serious adverse events | DKP or DKP combined with Diane-35 produce a slight improvement in insulin sensitivity compared with Diane-35 alone in PCOS patients | |
| E00-E90 Endocrine, nutritional and metabolic diseases | Fan | 2019 | China | Graves disease | 96/96; (28/68; 22/74) | 96/96; (28/68; 22/74) | 37.0±13.2;36.5±12.7/NR | Xiakucao Oral Liquid(2time/day,6months) and 131I | 131I | 1) Level of FT3, FT4, TSH 2) Levels of TRAb, TGAb, TPOAb | NR | Xiakucao Oral Liquid combined with 131I can effectively reduce the levels of serum TRAb, TGAb, and TPOAb in patients with Graves disease, and the efficacy of Xiakucao Oral Liquid combined with 131I is significantly better than 131I treatment only. |
| E00-E90 Endocrine, nutritional and metabolic diseases | Huang | 2019 | Taiwan | Type 2 diabetes | 21/20; (13/8; 8/12) | 21/20; (13/8; 8/12) | 50;56/10;11.5 | YH1(Rhizoma Coptidis, Shen-Ling-Bai-Zhu-San) + oral hypoglycemic agents (OHAs), 12weeks | Placebo + oral hypoglycemic agents (OHAs). | 1) HbA1c level 2) FPG and 2hPG levels, homeostatic model assessment (HOMA) of insulin resistance (IR), HOMA-β, lipid profile, body weight, waist circumference, in clinical symptoms | No serious adverse events occurred during this clinical trial | This pilot study indicates that YH1 together with OHAs can improve hypoglycemic action and β-cell function in overweight/obese patients with poorly controlled type 2 diabetes. YH1 is a safe add-on medication for OHAs and has beneficial effects on weight control and lipid metabolism. A larger study population with longer treatment and follow-up periods is required for further verification. |
| E00-E90 Endocrine, nutritional and metabolic diseases | Khaki | 2019 | Iran | Polycystic Ovary Syndrome | 30/30; NR | 30/30; NR | 23.0±3.08;24.13±4.45/NR | Auriculotherapy(every other day, last 10 days in each menstrual cycle , 20 sessions) | Medication, 1 to 5 days of menstrual cycle for 21 nights, and discontinuation of the drugs for 7 days. They received drugs for three consecutive cycles. cyproterone compound drugs or oral contraceptives | 1) Hirsutism score | NR | Auriculotherapy can play a role in reducing the symptoms of hirsutism, hair loss, and acne in single girls with PCOS, and even can control weight gain. |
| E00-E90 Endocrine, nutritional and metabolic diseases | Lyu | 2019 | China | Type 2 diabetes mellitus | 32/34; (16/16; 20/14) | 32/34; (16/16; 20/14) | 65.5 ± 5.06; 67.26 ± 4.81/ 11.66 ± 6.45; 12.38 ± 7.21 | Self-acupoint massage (SEAM, ST36, SP6, BL20, CV12, BL23, KI3, ST44, EXB5, LU5, LU10) + routine nursing interventions, 12 weeks | Routine nursing interventions | 1) blood glucose level: fasting blood glucose (FBG), 2-hour postprandial blood glucose (2hPG), glycosylated hemoglobin (HbA1c). 2) Diabetes-Specific Quality of Life Scale (DSQLS) | NR | As SEAM eff ectively decreased older adults’ HbA1c level and improved their quality of life, it can be used as a complementary approach to routine nursing interventions for community-dwelling older adults with T2DM. |
| E00-E90 Endocrine, nutritional and metabolic diseases | Qian | 2020 | China | Diabetic macular edena | 30/30; (16/14; 15/15) | 30/30; (16/14; 15/15) | 61.22±7.52;61.89±7.21/NR | Yiqi Yinshui Xiaozhong decoction (bid, 4 weeks/cycle, 3 cycles) + © | Anti-vascular drug injection + photocoagulation | 1) The best corrected visual acuity(BCVA) 2) Macular foveal thickness(CMT) 3) The macular fluorescence leakage in fluorescein fundus angiography(FFA) 4) Recurrence rate of macular edem | NR | Combined application of the Yiqi Yinshui Xiaozhong decoction, anti-VEGF drugs and laser to treat diabetic macular edema can improve vision, reduce macular edema, reduce the recurrence rate of edema, and bring better prognosis for patients |
| E00-E90 Endocrine, nutritional and metabolic diseases | S | 2020 | China | Diabetic peripheral neuropathy | 50/50; (26/24; 27/23) | 50/50; (26/24; 27/23) | 55.3±4.9;54.8±6.3/4.3± 0.7;3.2±0.6 | Ma Tong San and Huoxue Tongluo Chinese medicine foot bath Guizhi, Liu Jinu, Achyranthes bidentata, Turmer ic, Nepeta, Artemisia spp., Chuanjiao 15 g each, Chuanxiong, Angelica, Chu a nwu, Caowu each 10 g, Earthworm, Chicken Blood Vine, Su 30 g of wood, osteophyte, and stretched grass. Fry 300 mL of juice into a footbath bucket, add water to the knees, and maintain the temperature at 38 ° C once a day for 20 to 30 minutes each for 12 weeks. | Conventional medicine | 1) Clinical efficacy 2) TCSS score 3) TCM syndrome score 4) SCV of median nerve ulnar nerve, and common peroneal nerve 5) Adverse reactions | None | The combination of Ma Tong San and Huoxue Tongluo traditional Chinese medicine foot bath for diabetic peripheral neuropathy can improve the curative effect without increasing the risk of adverse reactions. |
| F00-F99 Mental and behavioural disorders | Armond | 2018 | Brazil | Postoperative symptoms after surgical removal of Mandibular third molars | 18/18; NR | 17/17; (3/14; 3/14) | 22.5± 3.45/ nr | Acupuncture(GV20, Yintang, LI4, LIV3, ST44, SJ21, SI19, ST6, ST7, UB60, GB34, the first 30 minutes prior to surgery and the others at 24, 48, and 72 hours following surgery) | Placebo acupuncture | 1) Visual analogue scales 2) Facial swelling (edema) 3) Maximum mouth opening 4) Spielberger State Trait Anxiety Inventory | None | NR |
| F00-F99 Mental and behavioural disorders | Asgari | 2019 | Iran | Poor sleep quality in patients undergoing percutaneous coronary interventions | 17/17/17/17(control); (17/0; 17/0; 17/0; 17/0) | 17/17/17/17(control); (17/0; 17/0; 17/0; 17/0) | 59.6±11.1;59.6±11.5;56.4±11.6;59.2±9.3;57.6±7.8/NR | 1) Aromatherapy(Citrus aurantium) 2) Placebo aromatherapy 3) Acupressure(HT7) 4) Placebo acupressure (acupressure applied to a point not traditionally associated with improving sleep), 10pm to 8am the following day | Routine care | 1) Sleep quality: visual analog scale (VAS) | None | The present findings provided scientific evidence for the benefits of using different methods, including acupressure, for sleep quality in patients undergoing PCIs. |
| F00-F99 Mental and behavioural disorders | Aygin | 2019 | Turkey | Anxiety and Sleep Quality After Cardiac Surgery | 52/50; NR | 50/50; (24/26; 32/18) | 60.62 ± 6 8.29; 58.24 6 ± 9.27/ nr | Acupressure(H7, MC6 5 PC6, GB20, ST6, once a day for 3 days) + standard care | Standard care | 1) Vertical visual analog scale for evaluating the level of anxiety 2) Richards-Campbell Sleep Questionnaire | NR | Our findings showed that acupressure decreased the level of anxiety and improved the sleep quality in the surgical clinic after cardiac surgery. |
| F00-F99 Mental and behavioural disorders | Borji | 2019 | Iran | Postoperative symptoms after Tonsillectomy | 48/48/48; (26/22; 28/20; 28/20) | 48/48/48; (26/22; 28/20; 28/20) | 7.76; 8.27; 7.67/ nr | 1) Acupressure(Yintang) 2) Sham(sham point) | Routine care | 1) Modified Yale Preoperative Anxiety Scale (mYPAS) | NR | Like other surgical procedures, the tonsillectomy has serious stress for children. Our study demonstrates that the acupressure has a significant effect on the level of preoperative anxiety in children undergoing surgery. Therefore, nurses can use this technique to reduce the pediatric anxiety. |
| F00-F99 Mental and behavioural disorders | Deng | 2019 | China | Tumor-related depression | 30/30; (11/19; 10/20) | 30/30; (11/19; 10/20) | 53±9/49±11; 9.4±2.8m/9.3±2.6m | Acupuncture therapy(LI4, PC6, LR3, HT7) + oral sertraline hydrochloride, twice a week, 4 weeks | Sertraline hydrochloride, first 5 days 25mg/d, then 50mg/day, 4 weeks | 1) Hamilton depression scale (HAMD) score 2) Quality of life score(QLQ-C30 questionnaire) | NR | The combination of acupuncture and sertraline hydrochloride tablets is better than simple sertraline hydrochloride in the treatment of tumor-related depression, and it can improve the accompanying symptoms and improve quality of life |
| F00-F99 Mental and behavioural disorders | Feng | 2018 | China | Post-traumatic stress disorder | 60/60/60/60; (19/41; 15/45; 22/38; 15/45) | 60/60/60/60; (19/41; 15/45; 22/38; 15/45) | 40.6 ± 12.5; 41.0 ± 12.8; 40.9 ± 12.7; 44.5 ± 12.9/ 10.9 ± 12.6; 8.5 ± 12.8; 12.2 ± 19.1; 11.4 ± 13.1 | 1) Transcutaneous electrical acupoint stimulation (TEAS) + sertraline 2) Cognitive behavioral therapy (CBT) 3) TEAS +CBT 4) TEAS +CBT +sertraline | 1) Clinician-Administered PTSD Scale 2) PTSD Check List- Civilian Version 3) 17-item Hamilton Rating Scale for Depression. | No severe adverse events. Both sertraline-containing groups (A and D) had a significantly higher incidence of overall adverse events compared with the other two groups (χ2 = 21.018, P < 0.001) | Additional TEAS augments the anti-PTSD and antidepressant efficacy of antidepressants or CBT, without increasing the incidence of adverse effects. TEAS could serve as an effective intervention for PTSD and comorbid depression. | |
| F00-F99 Mental and behavioural disorders | Fuladi | 2020 | Iran | Generalized anxiety disorder | 18/22; (11/7; 11/11) | 18/22; (11/7; 11/11) | median 39.89;40.50 | Withania somnifera (W. somnifera) root extract(1g/day, 6 weeks) + Selective Serotonin Re-uptake Inhibitors (SSRIs) | Placebo + Selective Serotonin Re-uptake Inhibitors | 1) Severity of GAD symptoms: Hamilton anxiety rating scale | The extract was safe and no adverse effect was observed during the trial. | W. somnifera extract may be advantageous as a safe and impressive adjunct to SSRIs in the treatment of GAD and well tolerated. |
| F00-F99 Mental and behavioural disorders | Gao | 2020 | China | Moderate major depressive disorder | 33/33/34; NR | 33/33/34; NR | 35±13.2;38±10.6;39±12.9/ 3±1.6;3.5±1.2;4±0.8 | Rhodiola capsules(0.6g/d) + Sertraline(1) vs Rhodiola capsules(0.3g/d) + Sertraline(1) + Placebo(1) | Sertraline(1) + Placebo(2) | 1) Hamilton Depression Rating (HAM-D) 2) Beck Depression Inventory (BDI) 3) Clinical Global Impression Change (CGI)C) | No patients reported serious adverse side-effects of the medications and none were excluded through non-compliance with the prescribed treatment. | It is concluded that the Rhodiola capsule shows anti-depressive potency in patients with depression disorder when administered in dosages of either 0.3 or 0.6 g/day over a 12-week period. Rhodiola capsule can improve the quality of life and clinical symptoms.The high doses of Rhodiola capsule are better than the lower doses. |
| F00-F99 Mental and behavioural disorders | Gol | 2020 | Iran | Stress and Serum Cortisol Level Before Rhinoplasty Surgery | 33/33; (29/4; 27/6) | 33/33; (29/4; 27/6) | 29.90±6.88;28.80±6.40/NR | Ear acupressure: Shen men, Subcortex, the brain stem 4 turns or two minutes per point, twice a day every 12hours, three days before the surgery | 1) Spielberger’s implicit and explicit stress | NR | Overall, performing ear acupressure before rhinoplasty can reduce stress (implicit and explicit) and serum cortisol levels. | |
| F00-F99 Mental and behavioural disorders | Jin | 2020 | China | Autism spectrum disorder | 30/30; (22/8; 21/9) | 30/30; (22/8; 21/9) | 3.9±0.9; 4.1±0.9/3.6±1.0;3.5±1.1 (yr) | catgut embedding therapy Shenting (GV 24), Baihui (GV 20), Shenmen (HT 7) and the optic area (the point of scalp acupuncture),once a week,4weeks/course,at the interval of 1 week between the courses,3course | Routine ASD rehabilitation training: conductive education, speech training and music therapy, once a day, 4weeks/course, at the interval of 1 week between the courses, 3 course | 1) Autism treatment evaluation checklist (ATEC) 2) The autism behavior checklist (ABC) | NR | The combined treatment of acupoint catgut embedding therapy with the rehabilitation training effectively improves in the joint attention and social communication. The therapeutic effect of this combined treatment is better than the simple application of rehabilitation training. |
| F00-F99 Mental and behavioural disorders | Martin | 2020 | USA | Emergence delirium in children undergoing myringotomy tube placement | 25/24/25/25; (15/10; 10/14; 18/7; 18/7) | 25/24/25/25; (15/10; 10/14; 18/7; 18/7) | 2.52 ± 1.2; 2.54 ± 1.7; 2.16 ± 1.5; 2.52 ± 1.4 | 1) Midazolam + intraoperative acupuncture(bilateral HT7, ear Shen Men points) 2) No midazolam + intraoperative acupuncture | 3) Midazolam + standard anesthesia care 4) No midazolam + standard anesthesia care | 1) Pediatric Anesthesia Emergence Delirium (PAED) scale | NR | Intraoperative acupuncture at HT7 and ear Shen Men did not reduce PAED scores after myringotomy tube placement. Based on these data, it is therefore unlikely that a larger study of the same design would demonstrate a significant effect of intraoperative acupuncture on emergence delirium after brief sevoflurane anesthesia. However, other acupuncture points or techniques could be considered. |
| F00-F99 Mental and behavioural disorders | Pouy | 2019 | Iran | Preoperative anxiety in mothers with a child undergoing tonsillectomy | 61; NR | 61; NR | 36.6 ± 6.9; 37.2 ± 7.3/nr | Acupressure(Yintang, deep massage and clockwise rotation, 5 min) | Sham acupressure, sham point, superficial massage | 1) Spielberger State-Trait Anxiety Inventory (STAI) | NR | The results of this study revealed that the acupressure has a positive effect on the attenuation of anxiety in mothers with a child undergoing tonsillectomy. Therefore, due to cost-effectiveness and ease of use, this technique is recommended to alleviate the anxiety in mothers whose children are undergoing surgery. |
| F00-F99 Mental and behavioural disorders | Song | 2020 | China | Acute alcohol withdrawal syndrome | 62/63; (62/0; 63/0) | 57/60; NR | 45.51±9.75;44.54±8.32/ 9.53±4.35;10.14±5.16 | Transcutaneous electrical acupoint stimulation (LI4, PC8, PC6, SJ5, twice a day, 14 days) + diazepam | Sham TEAS + diazepam | 1) The Clinical Institute Withdrawal Assessment for Alcohol Scale (CIWA-Ar) 2) Visual analogue scale (VAS) 3) Pittsburgh Sleep Quality Index (PSQI) 4) Modified Epworth Sleepiness Scale (mESS) | Adverse events(6): 2 cases of light tingling, 2 cases of skin redness at contact site, 1 case of insomnia and 1 case of temporary hand paralysis | Combining diazepam with TEAS may result in milder AWS symptoms than diazepam alone, improve sleep quality and reduce sleepiness. |
| F00-F99 Mental and behavioural disorders | Yeung | 2019 | hongKong | Tapering off long-term benzodiazepine use | 72/72; (23/49; 16/56) | 72/72; (23/49; 16/56) | 58.0±9.4;57.0±11.8/6.2±6.9;6.3±4.9 | Electroacupuncture(EX-HN1, EX-HN22, GB8, ST8, EX-HN5, GB15, PC6, HT7, SP), LV3, unilateral EX-HN3, GV24, GV20), 4 weeks | Placebo acupuncture (non-invasive placebo needles) | 1) Cessation rate of benzodiazepine use 2) Reduction in benzodiazepine usage 3) Benzodiazepine Withdrawal Symptom Questionnaire (BWSQ) 4) Hospital Anxiety and Depression Scale (HADS) 5) Credibility of Treatment Rating Scale (CTRS) | Pain at needle sites, needle site bruises, needle site bleeding and headache were more frequently reported in the electroacupuncture group (All P < .05). Withdrawal due to adverse events was 8.3% and 2.8% for the electroacupuncture and placebo acupuncture groups, respectively, which was not significantly different (P=.28). Two serious adverse events were reported. One participant in the electroacupuncture group was hospitalized due to photosensitivity; one in the placebo acupuncture group reported vomiting, diarrhea and fever, and was hospitalized. These two serious adverse events were considered uNRelated to the acupuncture intervention. | Electroacupuncture showed a similar cessation rate in benzodiazepine use to that of non-invasive placebo acupuncture in long-term users during a 4-week gradual tapering schedule. The evidence did not support advantages of electroacupuncture over non-invasive placebo acupuncture on reducing insomnia, anxiety, depression, or other withdrawal symptoms during the gradual tapering schedule. Despite a 40% decrease in the benzodiazepine usage in both groups, the effects may be attributed to the non-specific effects of acupuncture. |
| F00-F99 Mental and behavioural disorders | Zhao(2) | 2019 | China | Moderate to severe depression | 161/160/156; (56/105; 52/108; 57/99) | 161/160/156; (56/105; 52/108; 57/99) | 41.42±12.53;41.18±12.00;41.76±12.85/ 12.83±17.09;10.77±15.32;9.52±13.85 | 1) Manual acupuncture (MA) + selective serotonin reuptake inhibitors (SSRIs), 6 weeks 2) Electroacupuncture (EA) + SSRIs, 6 weeks | SSRIs | 1) Response rate of 17-item Hamilton Depression Scale (HAMD- 17) 2) HAMD-17 factor scores at 1st, 2nd, 4th, 6th, 10th week and WHO Quality of Life-BREF (WHOQOL-BREF) scores at 6th week | NR | Either MA or EA combined SSRIs treatment could improve symptoms and quality of life for patients with moderate to severe depression. The main limitation of this trial was not using a sham control therefore the placebo effect could not be excluded |
| F00-F99 Mental and behavioural disorders | Zhao(2) | 2020 | China | Protracted alcohol withdrawal symptoms among male inpatients | 31/31; NR | 31/30; NR | 41.88±6.72;42.56±6.31/ 10.61±4.38;11.03±4.29 | Electroacupuncture (GV20, GV26, HT7, LI4, PC6, 5d/w, 4w) + Escitalopram | Sham-EA + escitalopram | 1) Homocysteine (Hcy) test 2) Electrophysiological tests 3) Including event-related potentials (ERPs) 4) Exploratory eye movement (EEM) 5) The global scores of Penn Alcohol Craving Scale (PACS) 6) 17-items Hamilton Depression Rating Scale (HAMD-17) 7) Hamilton Anxiety Scale (HAMA) | No serious adverse events were re- ported | (1) Escitalopram with EA may be a potential alternative therapy for mitigating PAWS among male inpatients with alcohol dependence. (2) Escitalopram with EA might improve the alcohol- dependence induced cognitive dysfunctions via upregulating the expression of Hcy |
| F00-F99 Mental and behavioural disorders | Zhao(3) | 2019 | China | Moderate to severe depressed patients | 161/160/156; (56/105; 52/108; 57/99) | 41.42±12.53; 41.18±12.00; 41.76±12.85/ 12.83±17.09 10.77±15.32 9.52±13.85 | 1) Manual acupuncture (MA, GV20, EX-HN3, GV16, GB20, GV14, PC6, SP6) +SSRIs 2) Electroacupuncture (EA, GV14, GV16, PC6, SP6) +SSRIs, 6 weeks | SSRIs | 1) Response rate of the 17-item Hamilton Depression Scale (HAMD-17) 2) HAMD-17 (remission rate, early onset rate, total score) 3) Self-Rating Depression Scale (SDS: total score) 4) Clinical Global Impression (CGI) 5) Rating Scale for Side Effects (SERS: total and domain scores) 6) Number of patients with adjusted dosage of SSRIs and adverse events (AEs) | No unintended acupuncture-related severe AE was observed | This study identified that both MA and EA showed beneficial effects in addition to SSRIs alone in patients with moderate to severe depression, and were well tolerated. | |
| F00-F99 Mental and behavioural disorders | Zhao(5) | 2019 | China | Post-stroke depression | 54/54; (30/24; 28/26) | 54/54 (30/24; 28/26) | 65.1±10.1; 63.3±9.9/ nr | Routine medication, psychological counseling, and rehabilitation exercise, Xingnao Kaiqiao acupuncture(PC6, BL40, SP6, ST2, EX-HN1, once a day, 7 days/course, 4 courses/cycle, 2 cycles | Routine medication, psychological counseling, and rehabilitation exercise, 2 cycles | 1) Hamilton Depression Rating Scale 2) Self-Rating Anxiety Scale 3) National Institutes of Health Stroke Scale 4) Modified 36-item Short-Form Scale of Health-related Quality of life 5) Manual muscle testing | NR | Acupuncture enhances clinical treatment effect, improves psychological state, promotes recovery of muscle strength, and thus improves QoL of patients with post-stroke depression, and can be applied as a routine complementary treatment among those patients. Keywords: Post-stroke depression |
| F00-F99 Mental and behavioural disorders | Zhu | 2020 | China | Post Stroke Depression | 35/35; NR | 35/34; (16/19; 14/20) | 63.27±8.97;61.35±9.43/NR | Electroacupuncture (baihui, yintang, shenting, sishencong, 30min, once a day, 6 times/week, 2weeks)+ conventional treatment | Conventional treatment | 1) NIH stroke scale （NIHSS） 2)HAMD | NR | EA can promote the recovery of neural function and also reduce the depressive symptoms in patients with PSD of stagnation of liver qi. |
| G00-G99 Diseases of the nervous system | Bao | 2019 | China | Blepharospasm | 15/15/35(Healthy); (3/12; 4/11; 10/25) | 15/15/35(Healthy); (3/12; 4/11; 10/25) | (Healthy subject 63.29 ± 6.10; BP patients(63.80±10.96)) A. 65.87 ± 11.67; B. 61.73 ± 10.17/ 3.93 ± 3.02; 3.87 ± 2.75 | 1) Acupuncture treatment(BL2, SJ23, ST2, LI4, ST36, SP6, LR3) 2) BTA injection | 1) LET | BTA injectoon:Yet, repeated injections pose a risk to develop neutralizing antibodies and are associated with adverse side effects such as dysphagia and dysphonia. | Blepharospasm patients have an increased LET. Both BTA and acupuncture are effective in decreasing the LET. Close monitoring of LET holds promise in planning the treatment strategy for Blepharospasm. | |
| G00-G99 Diseases of the nervous system | Chen | 2019 | China | Extubation in stroke patients undergoing tracheotomy | 37/37; (28/9; 26/11) | 37/37; (28/9; 26/11) | 56.7±9.1/58.6±9.1; 86.6±39.9/86.0±37.9 | “Tongyuan”acupuncture treatment (GV20, GV12, CV4, CV6, ST25, BL13, BL20, 30 min/d, 6 times/w, 4 weeks) | Scalp acupuncture therapy(MS6, MS7, MS9, filiform needles, 30 minutes each time, once daily, 6 times a week for 4 weeks) | 1) Cough reflex grading score 2) Clinical pulmonary infection score 3) Swallowing function | NR | “Tongyuan”acupuncture treatment can improve cough reflex to remove sputum,reduce pulmonary infection,enhance swallowing function,and raise the success rate of extubation in stroke patients, which is better than scalp acupuncture. |
| G00-G99 Diseases of the nervous system | Chen(3) | 2020 | China | Parkinson's Disease and Syndrome of Shen (Kidney) Essence Deficiency | 43/43; NR | 35/37; (24/11; 25/12) | 64.17±6.11;65.20±7.44/5.05±3.09;4.78±2.97 | Congrong Shujing Granules(CSGs) + Western medicine (WM), bid, 12 w | Placebo + WM | 1) The Unififi ed Parkinson's Disease Rating Scale (UPDRS) score 2) the PD Question-39 (PDQ-39) score 3) CM Syndrome Scale score 4) drug usage 5) Safety 6) gene ontology analysis and Kyoto Encyclopedia of Genes and Genomes pathway analysis | 2 cases in treatment group with adverse events were observed. internal heat, thirsty, and dryness heat. | CSGs combined with WM can be used to treat PD patients with CM syndrome of Shen essence defifi ciency with a good safety. The possible mechanism of action and relevant gene loci were proposed. |
| G00-G99 Diseases of the nervous system | Collinsworth | 2019 | USA | Postoperative shoulder pain | 21/20; NR | 21/19; (17/4 ;14/5) | 20.33± 1.56; 20.5± 1.23/ nr | Battlefield Acupuncture (BFA, Cingulate Gyrus, Thalamus, Omega 2, Point Zero, Shen Men) + standard-of-care, 3–5 days within 24 hours after shoulder surgery, 6 weeks | Standard care | 1) Pain- visual analogue scale 2) Global Rating of Change 3) Patient Specific Functional scale | None | BFA reduced postsurgical shoulder pain significantly between the groups’ average and worst pain change scores between baseline and 7 days despite similar opioid and nonsteroidal anti-inflammatory drug use between the groups. |
| G00-G99 Diseases of the nervous system | Gao | 2019 | China | Spastic cerebral palsy | 23/29; (13/10; 14/15) | 23/29; (13/10; 14/15) | 43.13 ± 18.53; 40.07 ± 13.88/ NR | Scalp acupuncture(5 days/week, 3 months) + exercise therapy | Conventional rehabilitation training, 5 days per week, 3 months | 1) Gross motor function(GMFM-88) 2) Activity of Daily Life | NR | Scalp acupuncture combined with exercise therapy and conventional rehabilitation training can significantly improve gross motor function and the ability to perform ADLs in children with spastic cerebral palsy compared to conventional rehabilitation training alone. |
| G00-G99 Diseases of the nervous system | Guo | 2019 | China | Limb paralysis | 35/35; NR | 30/30; (19/11; 21/9) | 52.3±6.5;53.1±5.8/10.3±2.7;9.6±3.4(hrs) | Acupuncture(ST40, ST36, CV4, (GV20, GV26, GB20) + medication(Mannitol Injection(125 mL, once every 8h) + Oxiracetam Injection(4g, once a day), Starting 72 h after TBI) | Medication(Mannitol Injection(125 mL, once every 8 h) + Oxiracetam Injection(4g, once a day). Starting 72h after TBI | 1) Plasma IL-6,BDNF and NGF contents 2) Volume of the injured brain tissue 3) Glasgow Coma Scale（GCS） 4) Fugl-Meyer assessment（FMA）scale+modified Barthel index（BI） | NR | Early acupuncture treatment can significantly improve the TBI patient’s limb motor function and daily life activities,which may be related with its effects in reducing the inflammation and increasing BDNF and NGF levels. |
| G00-G99 Diseases of the nervous system | Huang | 2019 | China | Peripheral facial paralysis | 24/24; (11/13; 12/12) | 24/24; (11/13; 12/12) | 48±11;50±11/15.5±0.5;15.2±0.7(hr) | Acupuncture (TE 17, SI 18, EX-HN 5, ST 2, ST 6, ST 4, LI 4(opposite), 30 min a day, once every other day) + Prednisone(30 mg, decrease 10 mg every 3 days, 9 days) | Acupuncture(TE 17, SI 18, EX-HN 5, ST 2, ST 6, ST 4, LI 4, opposite side, 30 min a day, once every other day) | 1) Portmann score | NR | Simple acupuncture treatment on peripheral facial paralysis with normal result of facial nerve magnetic resonance examination can achieve the same effect of acupuncture combined with drugs, and avoid drug-related adverse reactions. |
| G00-G99 Diseases of the nervous system | Jaić | 2019 | Croatia | Pain relief after episiotomy | 29/31; NR | 29/31; NR | 32/ 30 | Auricular acupuncture(Internal genital area, external genital area and Shen Men point, first three postpartum days) | No acupuncture | 1) Pain intensity: visual analogue scale (VAS) 2) Need for analgesics, the amount of given analgesics, the number of analgesic repetitions during the day | None | Our findings confirm that auricular acupuncture therapy may be a valuable adjunct to analgesic therapy in patients undergoing episiotomy during vaginal delivery. The results prompt a question whether our current ‘best practice’ may yet be improved. |
| G00-G99 Diseases of the nervous system | Ji | 2019 | China | Spastic cerebral palsy with spleen-kidney deficiency | 110/110; (67/43; 69/41) | 110/110; (67/43; 69/41) | 3.7±0.8/3.6±0.9; 26.5±5.0/26.3±6.6 | Acupuncture therapy(ST36, GB39, SP6, BL20, BL23, CV6, LI1, PC6, LI4, ST25, 10 min, 3 times/week) + repetitive transcranial magnetic stimulation + rehabilitation training, 3 months | Repetitive transcranial magnetic stimulation(30 min/session, 1 times/day,5 times/week) + rehabilitation training | 1) Gross motor function measure,GMFM 2) Fine motor function measure,FMFM 3) Comprehensive function score 4) Clinical outcome 5) Related cerebral hemodynamic parameters(Vm,Vs,RI) | NR | In the treatment of children with spasmodic cerebral palsy with spleen-kidney deficiency,acupuncture combined with repeated transcranial magnetic stimulation can significantly improve their motor function,comprehensive function,and clinical outcome,which may be associated with the regulation of cerebral hemodynamics. |
| G00-G99 Diseases of the nervous system | Jin | 2019 | China | Cerebral palsy | 33/35; (21/14; 18/15) | 33/35; (21/14; 18/15) | 22.9±10.3;21.7±10.2(months)/NR | Thread-embedding therapy(LI15, SJ14, Si11, ST25, C4, L1, L4), once a week, 4 weeks/course, 3 courses | Routine rehabilitation treatment,once a day,6 times/week,3weeks/course,with an interval of one week between two courses,3course | 1) Level of sitting scale（LSS） 2) Incurvation reflex 3) GMFM score | NR | In addition to routine rehabilitation treatment,acupoint thread-embedding therapy can effectively suppress primitive reflex in ataxia children with cerebral palsy and significantly promote their sitting ability,and therefore,it is an effective acupuncture treatment method for ataxia children with cerebral palsy |
| G00-G99 Diseases of the nervous system | Li(12) | 2019 | China | Migraines | 39/39; (19/20; 17/22) | 39/39; (19/20; 17/22) | 41.6±4.9; 43.8±5.7/3.3±0.2; 3.2±0.4 | Acupuncture(Shuaigu, Fengchi, Neiguan, Yongquan, Taichong, once a day for 2 months) + Sibelium | Sibelium 5 mg/day for 2 months. | 1) Duration of migraine attacks 2) Frequency of migraine attacks 3) VAS scores 4) Efficacy of treatment 5) Concomitant symptoms of migraine attacks during treatment | NR | Sibelium combined with acupuncture can effectively alleviate clinical symptoms of migraine attacks. This method is superior to Sibelium monotherapy in terms of clinical efficacy. Therefore, it is worthy of promotion in clinic practice. |
| G00-G99 Diseases of the nervous system | Li(3) | 2020 | China | Cancer pain | 30/30; (17/13; 19/11) | 30/30; (17/13; 19/11) | 58±11;55±12/NR | Acupuncture therapy (LI 4, PC 6, ST 36, SP 6, Corresponding back-shu points, xi-cleft points and ashi points, once a day, 2weeks) | Oxycodone hydrochloride prolonged-release tablet ,10-30mg, once 12hr, 2 weeks | 1) Karnofsky performance status (KPS) 2) Quality of life (QOL) scale scores 3) Numerical rating scale (NRS) score | NR | Acupuncture combined with opioid drugs can effectively relieve the cancer pain, improve theperformance status and quality of life in cancer patients, reduce the dosage of opioid drugs and adverse reactions rate. |
| G00-G99 Diseases of the nervous system | Li(9) | 2019 | China | Stroke | 32/32/32; NR | 32/32/32; NR | 55±9;56±8;57±10/15±2;15±4;16±3(d) | Electroacupuncture, once a day. 4 weeks /course , 3 courses + Proprioceptive neuromuscular facilitation (PNF), 20min, once every day | 2) Proprioceptive neuromuscular facilitation (PNF), 20 min, once a day 3) Electroacupuncture(GB 34, GB 39) | 1) Average trace error (ATE) and Time 2) Fugl-Meyer scale (FMA) 3) Modified Barthel index (MBI) | NR | Electroacupuncture, PNF and combination therapy can improve proprioception and motor function of lower limbs and activities of daily living, and combination therapy has a better effect. Proprioception and motor function have a strong correlation in the recovery of stroke patients |
| G00-G99 Diseases of the nervous system | Lin(2) | 2019 | China | Sepsis associated encephalopathy | 32/32; (24/8; 22/10) | 32/32; (24/8; 22/10) | 62.2±7.8;61.2±11.2/NR | Tongdu Tiaoshen”needling treatment + conventional medicines | Conventional medicines | 1) Montreal Cognitive Assessment（MoCA）scale 2) Serum interleukin⁃6（IL⁃6） 3) Radioimmunoassay,serum C⁃reactive protein（CRP) 4) Arterial blood lactic acid（Lac） | NR | “Tongdu Tiaoshen”needling can significantly improve the cognitive function of SAE patients,which may be associated with its effect in reducing inflammatory reaction of sepsis |
| G00-G99 Diseases of the nervous system | Molasiotis | 2019 | hongKong | Chemotherapy-Induced Peripheral Neuropathy | 44/43; (9/35; 15/28) | 44/43; (9/35; 15/28) | 전체: 57.1 ± 7.7 | Acupuncture(LI4, LI11, PC7, TE5, and/or Baxie points, SP6, ST36, LV3, ST41, and/or Bafeng, twice weekly for 8 weeks) | Standard care | 1) Pain: Brief Pain Inventory (BPI) 2) Functional Assessment of Cancer Therapy)Gynecologic Oncology Group–Neurotoxicity (FACT)GOG-Ntx) 3) The presence of other related symptoms: 10-item Symptom Distress scale 4) Total Neuropathy Score–Clinical Version (TNSc) 5) The National Cancer Institute–Common Toxicity Criteria for Adverse Events (CTCAE) 6) Neurophysiological testing included a detailed motor nerve conduction study (NCS) | NR | Acupuncture is an effective intervention for treating chemotherapy-induced peripheral neuropathy and improving patients’ quality of life and experience with neurotoxicity-related symptoms with longer term effects evident. |
| G00-G99 Diseases of the nervous system | Oztas | 2019 | Turkey | Abdominal surgery with a midline incision | 16/16/16; NR | 16/15/16; (11/5; 10/5; 11/5) | 60.88 ± 14.84; 61.87 ± 16.80; 56.31 ± 9.39 | 1) Transcutaneous electrical nerve stimulation (TENS, ST25, P6, ST36, Lİ4, frequencies of 2–100 Hz, 30 min) 2) Transcutaneous acupoint electrical stimulation (TAES, ST25, P6, ST36, Lİ4, frequencies of 2–100 Hz, 30 min) | No treatment | 1) Effects of TENS and TAES: Pain and analgesic drug consumption 2) Effects of TENS and TAES use: respiratory functions, vital signs, nausea and vomiting status, dizziness, antiemetic drug consumption, and saturation | NR | The research’s findings reveal that the two electrical stimulation methods have similar effects on pain scores and analgesic consumption in patients. |
| G00-G99 Diseases of the nervous system | Sen | 2019 | Turkey | Pain management after cardiac surgery | 52/50; NR | 50/50; (24/26; 32/18) | 60.62±8.29; 58.24±9.27/nr | Daily nursing care+ acupressure(H7, PC6, GB20, ST6, once a day, 3 days) | Daily nursing care | 1) Pain: Visual Analogue Scale (VAS) | NR | Consequently, the study showed that acupressure application done to H7, PC6, GB20, and ST6 points significantly decreased pain after cardiac surgery |
| G00-G99 Diseases of the nervous system | Tezel | 2019 | Turkey | Carpal tunnel syndrome | 26/25; NR | 24/20; (1/26; 1/19) | 47.1 ± 7.7; 46.6 ± 8.1/nr | Acupuncture(PC7, PC4, PC6, HT7, Lu9, Ll11, two times a week, five weeks) + night splinting | Night splinting | 1) Quality of life (Nottingham Health Profile, NHP) 2) Function (Boston Carpal Tunnel Questionnaire) 3) Pain (visual analogue scale, VAS) 4) Median nerve motor distal latency (DML), motor nerve conduction velocity (NCV), sensorial conduction velocity (SCV), sensory DL and palm-wrist sensory NCV measurements | Redredness at the application area in the acupuncture plus night splint-ing group(2). No serious adverse events related to acupuncture. | The effect of acupuncture plus night splinting may show significant reduction on pain but failed to show significant differences on the other outcomes compared to the night splinting group. Further studies with larger sample size may confirm the findings. |
| G00-G99 Diseases of the nervous system | Wu(5) | 2019 | China | Refractory cancer pain | 30/30; (15/15; 16/14) | 30/30; (15/15; 16/14) | 56±3; 58±3/3.5±1.2; 2.5±1.1(yr) | Wrist-ankle needle, once a day, 10 days | Opioid drugs in accordance with the three-step analgesic principle and other auxiliary drugs | 1) visual analogue scale (VAS) score | NR | Wrist-ankle needle combined with opioid drugs can increase the efficacy of the refractory cancer pain and reduce the adverse reactions of opioid drugs. |
| G00-G99 Diseases of the nervous system | Xia | 2020 | China | Alzheimer's disease | 30/30; (17/13; 18/12) | 30/30; (17/13; 18/12) | 61±8;62±7/51.8±26.7;54.9±25.4(months) | Electroacupuncture (EA) at governor vessel (GV)(GV 20, GV16, once a day) + donepezil hydrochloride (5 mg, once a day, 8weeks) | Donepezil hydrochloride(5 mg, once a day, 8 weeks) | 1) The Montreal cognitive assessment (MoCA) 2) Alzheimer's disease assessment scale cognitive part (ADAS-Cog) 3) P300 (latency and amplitude of N2 and P3) 4) Amyloid precursor protein (APP) and β-amyloid protein 1-42 (Aβ1-42) | NR | EA at Baihui (GV 20) and Fengfu (GV 6) combined with donepezil hydrochloride can effectively reduce the serum levels of APP and Aβ1-42 and improve the scores of MoCA and ADAS-Cog and the levels of N2 and P3 of P300 in AD patients, which has superior effect to donepezil hydrochloride alone in improving the learning-memory of AD patients |
| G00-G99 Diseases of the nervous system | 2020 | China | Chronic Insomnia | 31/32/31; (3/28; 9/23; 6/25) | 31/32/31; (3/28; 9/23; 6/25) | 56.32±9.01;49.41±14.00;54.45±12.10/NR | 1) Electroacupuncture (DU-20, EX-HN1, EX-HN22, SP-6, HT-7, PC-6, BL-62, KI-6, 30 minutes at a time, 3 times/week, 4 weeks) 2) Cognitive behavioral therapy (90–120 minutes, once a week, 4 sessions) 3) EA+ CBT | 1) PSQI 2) ISI 3) ESS 4) DBAS-16 5) HAM-A 6) HAM-D | After EA: 3 cases of bleeding after needle insertion and 2 cases of subcutaneous bruising. After CBT: 19 cases of drowsiness, five cases of dizziness and headache, and two cases of blood pressure fluctuation | 1. Spirit-regulating EA therapy is effective. In terms of improving sleep quality and mood, EA has the same effect as CBT and can improve daytime function earlier. 2. 0e curative effect of the EA/CBTgroup lasts longer than that of the EA group, and EA/ CBT is better at improving daytime function compared to CBT alone and better at improving mood compared to CBTor EA alone. | ||
| G00-G99 Diseases of the nervous system | Xu | 2020 | China | Cancer pain | 40/40/40/40; NR | 39/40/40/40; (18/21; 19/21; 22/18; 24/16) | 64392;63.33;61.70;67.33/NR | 1) Conventional analgesia + wrist-ankle acupuncture (WAA) 2) Conventional analgesia +auricular acupuncture (AA) 3) Conventional analgesia + WAA + AA | Conventional analgesia | 1) The verbal rating scale (VRS) 2) Numeric rating scale (NRS) 3) Alagesic drug use | NR | WAA combined with AA can more quickly reduce pain symptoms with more lasting analgesic effects and can effectively reduce analgesic drug use |
| G00-G99 Diseases of the nervous system | Xu(3) | 2020 | China | Parkinson’s disease | 38/38; NR | 33/37; (15/18; 21/16) | 61.73±10.28;61.95±9.77/3.52±2.78;3.26±2.32 | Acupuncture(GV17, GB19, Sishenzhen and temporal three needle) + Madopar (levodopa and benserazide), 8 weeks | Madopar | 1) The Unified Parkinson's Disease Rating Scale (UPDRS) 2) Modified Webster Scale 3) Parkinson’s Disease Sleep Scale (PDSS) 4) Self-rating Depression Scale (SDS) | No serious drug- or acupuncture-related adverse events and complications were recorded | Integrated therapy showed a greater advantage, with earlier non-motor symptom improvement. This study also indicated that acupuncture had a certain long-term effect. |
| G00-G99 Diseases of the nervous system | Zhang(4) | 2019 | China | Delayed neuropathological sequelae | 13/13; (7/6; 5/8) | 13/13; (7/6; 5/8) | 65±5;62±5/5-22;6-25(d) | Xingnao Kaiqiao acupuncture (once every day, 5 days as one course, with an interval of 2 days between the course.,6course)+conventional therapy + hyperbaric oxygen(HBO) affected side:Shuigou (GV 26), Neiguan (PC 6), Baihui (GV 20), Shangxing (GV 23), Yintang (GV 29), Sanyinjiao(SP 6) slurred speech:Sishencong (EX-HN 1), Fenglong (ST 40), Lianquan (CV 23) and Jinjin (EX-HN12) upper limb pain:Jianyu (LI 15), Waiguan (TE 5) and Shousanli (LI 10) lower limb pain:Huantiao (GB 30), Yanglingquan (GB 34), Yinlingquan (SP 9) | Conventional therapy combined with hyperbaric oxygen(HBO) | 1) Head MR scan 2) Multi-inversion time arterial spin labeling(mTI-Asl) 3) Diffusion tensor imaging (DTI) scans 4) Matlab (R2014b), Mricron and Syngo 5) Ccerebral blood flow (CBF) 6) Anisotropy (FA) values | NR | Acupuncture combined with hyperbaric oxygen can significantly improved early white matter hypoperfusion and improved cognitive function score in patients with DNS. The curative effect is better than that of hyperbaric oxygen therapy alone. The mTI-ASL imaging can quantitatively evaluate its curative effect. |
| G00-G99 Diseases of the nervous system | Zhang(5) | 2019 | China | Spastic cerebral palsy | 31/31; (18/13; 17/14) | 31/31; (18/13; 17/14) | 20±3;21±2 (months)/NR | Acupuncture(GV 20, EX-HN1, EX-B 2, BL 40, GB 39, ST 36, LI 4, once a day, 5 days/w, 45d/course) | Comprehensive rehabilitation therapy (sport therapy,electronic biofeedback therapy, speech cognitive training, massage therapy) | 1) Gesell development scale adaptive DQ scores 2) Gross motor function measure (GMFM88) 3) Muscular tension of adductor and gastrocnemius muscle | NR | Acupuncture combined with comprehensive rehabilitation therapy can improve cognitive function, spasticity and motor function of children with spastic cerebral palsy |
| H00-H95 Diseases of the ear and mastoid process | Wu(2) | 2019 | China | Cataract with glaucoma | 34/34; (17/17; 16/18) | 34/34; (17/17; 16/18) | 50±7;48±7/ NR | Tuina + acupuncture, once every other day, 15 days/course, 2 courses | 0.5% phacoemulsification | 1) Intraocular pressure 2) Visual acuity 3) Pain severity 4) Aqueous outflow (F value) 5) Clinical symptoms | NR | Based on phacoemulsification, acupuncture and tuina could significantly reduce the IOP and F value, relieve pain and improve visual acuity in patients with cataract and glaucoma |
| H00-H95 Diseases of the ear and mastoid process | Yang | 2019 | China | Macular edema secondary to branch retinal vein occlusion | 40/40; (26/14; 25/15) | 40/40; (26/14; 25/15) | 58. 4±6. 7;58. 9±6. 4/ 3.4±0.5;3.6±0.4(months) | Yiqihuoxuehuayu decoction(twice a day,3 months) + intravitreal injection of triamcinolone acetonide + 532nm argon laser photocoagulation(once a month,1-3 times) | Intravitreal injection of triamcinolone acetonide combined with 532nm argon laser photocoagulation,once a month, 1-3 times. | 1) Corrected visual acuity (BCVA) 2) Central foveal thickness (CMT) 3) Intraocular pressure | NR | Yiqihuoxuehuayu decoction combined with triamcinolone acetonide and 532nm argon laser has definite efficacy in the treatment of ME secondary to BRVO,and it can improve visual acuity,reduce macular edema and promote fundus hemorrhage exudation absorption,and it has high safety． |
| H00-H95 Diseases of the ear and mastoid process | Zhao | 2019 | China | Acute suppurative otitis media | 94/92; (50/42; 48/46) | 94/92; (50/42;48/46) | 4.8±2.4;5.1±2.6/ NR | Ofloxacin ear drops + Bairui Granules (5g/time,3times/day,7-10days). | Ofloxacin ear drops (2—3 times a day, 6—10 drops each time; After ear dropping, taking 10 min ear bath,7-10days) | 1) Curative effect - Quantitative indicators of acute otitis media 2) Adverse reactions | NR | The ofloxacin ear drops can efficiently improve clinical symptoms of the patients with acute suppurative otitis media, and Bairui Granules have antipyretic and antiphlogistic effect. The combination of the two drugs had significant curative effect on acute suppurative otitis media in children with low adverse reactions incidence, so we conclude that it is worthy to be promoted. |
| I00-I99 Diseases of the circulatory system | Cai | 2019 | China | Ischemic stroke | 1568/1575; NR | 1508/1524; (989/519; 966/558) | 61.3±8.9;61.2±9.0/39.6±46.6;38.5±36.7 | Dengzhan Shengmai (DZSM, 0.36 g, bid, 12 months) + standard secondary preventive medications | Placebo + standard secondary preventive medications | 1) 1-year incidence of stroke 2) New major cardiovascular events 3) New peripheral artery events 4) All-cause mortality | The type and incidence of adverse events were similar in the DZSM and placebo groups. | The addition of DZSM capsules to standard secondary preventive agents provides additional benefits after the initial onset of ischemic stroke, reducing recurrent stroke without increasing severe adverse events. However, further study is needed to elucidate the role of DZSM on the updated practice of conventional secondary prevention for ischemic stroke. |
| I00-I99 Diseases of the circulatory system | Ceyhan | 2019 | China | Atrial Fibrillation | 36/36; NR | 30/30; (9/21; 11/19) | 64.0±12.6/63.4±13.5; NR | Acupressure with acupressure device (PC-6, HT-7, CV-1, 2-4 sessions/day) | Attach acupressure device without real pressure | 1) Pulse 2) Blood pressure 3) Brief fatigue inventory, BFI (developed by Mendoza et al) | NR | As a result of the study, it was determined that the acupressure decreased heart rate in patients with AF, it was effective in decreasing systolic and diastolic blood pressure at repeated administrations, and this decrease was not effective in reducing fatigue. According to these results, it could be recommended to perform the repeated acupressure administration along with pharmacological treatment for reducing heart rate and blood pressure in AF |
| I00-I99 Diseases of the circulatory system | Feng | 2019 | China | Ischemic stroke complicated with essential hypertension | 40/40; NR | 39/38; (23/16; 21/17) | 63±7/61±7; 11.0±6.8y/12.5±7.2y | Acupuncture(ST 9, once a day, 6 times/w, 4w) + Xingnao Kaiqiao acupuncture(1 time/d, 6 times/w, 4 w) + Nifedipine, 30mg/d, 4w | Xingnao Kaiqiao acupuncture + Nifedipine 30mg/times,1time/day,4weeks | 1) Morning blood pressure 2) Daytime peak blood pressure 3) Blood pressure load | NR | On the basis of Xingnao Kaiqiao acupuncture and nifedipine, acupuncture at Renying (ST 9) can effectively reduce morning blood pressure, daytime peak blood pressure and blood pressure load in patients with ischemic stroke complicated with essential hypertension. |
| I00-I99 Diseases of the circulatory system | Feng(3) | 2019 | China | Renal failure and hypertension | 30/30; (11/19; 15/15) | 30/30; (11/19; 15/15) | 61.83±13.03; 68.80±13.45/ 9.06±9.06 ; 6.43±7.11 | 1) Amlodipine besylate(5 mg/day) + acupoint application of traditional Chinese medicine nursing(Neiguan, Yongquan and Sanyinjiao, 75 mg/day), once a day for 2 weeks. | 2) Amlodipine besylate, 75 mg/day | 1) Biochemical analysis: urea nitrogen (BUN), creatinine (CRE), total protein (TP) and albumin(ALB), Urine protein (UP), N-acetyl-Glucosaminidase (NAG), creatinine clearance (Ccr) 2) H&E staining 3) Immunohistochemistry assay 4) Detection of expression level of associated mRNA by RT-qPCR 5) Western blotting | NR | Amlodipine besylate combined with acupoint application of traditional Chinese medicine nursing can effectively reduce the systolic pressure and diastolic pressure of patients, and improve the symptoms and signs of patients, which may be associated with the regulation of the expression of PI3K/AKT pathway, so as to regulate the expression of BUN, CRE, UP, BUP and NAG. |
| I00-I99 Diseases of the circulatory system | Gao(3) | 2020 | China | Left Ventricular Diastolic Dysfunction in Hypertensive Patients | 60/60; (31/32; 29/28) | 53/51; NR | 60;60 allocation 기준으로.. /60.28±9.20;61.77±10.65 | Bushenjiangya-optimized (BSJYO) + western medicine (WM), bid, 8 weeks | Conventional medicine | 1) Echocardiography 2) Traditional Chinese medicine (TCM) syndromes 3) 24-hour ambulatory blood pressure 4) Liver and kidney functions, 5) Adverse events. 6) Major adverse cardiovascular events (MACEs) | Tere were no differences in early adverse events | BSJYO granule plus basal WM is an effective and safe therapy for HTN patients with LVDD. |
| I00-I99 Diseases of the circulatory system | Guo(2) | 2019 | China | Stroke complicated with hypertension | 35/35; (13/22; 15/20) | 35/35; (13/22; 15/20) | 91±4;90±4/ 8.7±3.0;10.0±2.9(yr) | Huoxue Sanfeng acupuncture (ST 9, LI 11, LI 4, ST 36, LR 3, 1 time/day, 5 times/week, 10 times/cycle, 3 cycles) + Xingnao Kaiqiao acupuncture (GV 26, PC 6, SP 6, Shangjiquan, LU 5, BL 40, once a day, 5 times/w, 10times/ cycle, 3 cycles) + Nifedipine(30mg/d, 6w) | Xingnao Kaiqiao acupuncture(GV 26, PC 6, SP 6, Shangjiquan, LU 5, BL 40) + Nifedipine | 1) Morning blood pressure 2) 24 h blood pressure load | NR | On the basis of “Xingnao Kaiqiao acupuncture” combined with nifedipine controlled release tablets in the treatment of elderly patients with stroke complicated with hypertension, “Huoxue Sanfeng acupuncture” can further improve the function of nerve and limbs, effectively reduce the morning blood pressure level of elderly patients, especially diastolic blood pressure, and significantly improve systolic blood pressure and diastolic blood pressure load. |
| I00-I99 Diseases of the circulatory system | Huang | 2020 | Taiwan | Hypertension of elderly patients in home health care. | 35/35; NR | 31/31; (10/21; 11/20) | 70.87±5.65;72.87±5.55/NR | Antihypertensive drugs + acupuncture(SP10, SP6, LR3, ST36, LI4, 30 min, twice a week, 12 weeks) | Antihypertensive drugs | 1) Blood pressure (BP) 2) Heart rate variability 3) The Constitution in Chinese Medicine Questionnaire (CCMQ) | no obvious adverse effect occurred. | This study suggested that in the home health care hypertension population, antihypertensive drugs plus acupuncture may be more beneficial in lowering BP and in regulating autonomic nervous system activity than drugs alone. A longer follow-up and larger sample size should be considered in future studies to reveal the precise effect of acupuncture followed by evidence-based practice. |
| I00-I99 Diseases of the circulatory system | Li(10) | 2019 | China | Stable angina pectoris | 150/150; NR | 143/144; (73/70; 82/62) | 56.6±8.1;55.3±8.3/NR | Guanxinshutong (GXST, 0.3 g, tid, 4w) + standard antianginal treatment | Placebo + standard antianginal treatment | 1) Change from baseline in angina attack frequency 2) Reduction of nitroglycerin dose 3) Score of Seatntle Agina Questionnaire 4) Exercise tolerance test(time to onset of chest Pain and ST-segment depression at least 1 mm greater than the resting one) | 7 patients (4.1%) in the GXST group and 3 patients (2.1%) in the placebo group reported at least one adverse event, respectively | GXST capsules are beneficial for the treatment of SAP patients. |
| I00-I99 Diseases of the circulatory system | Li(4) | 2019 | China | Cerebral infarction | 40/40; (22/18; 25/15) | 40/40; (22/18; 25/15) | 61.9±7.9;63.6±6.9/ 16.9±7.1;18.5±8.1(days) | Nape acupuncture(30min, once a day, 10days/course, 3course) + General medicine therapy and swallowing functional training | General medicine therapy and swallowing functional training + fluoroguirizine hydrochloride capsules,10mg, 5days/week, 2weeks/course, 3course | 1)swallowing function test by fiberoptic nasopharyngoscopy 2)Rosenbek Penetration-Aspiration Scale (PAS) score 3)bedside water-swallowing test 4)standardized swallowing assessment (SSA) | NR | Nape acupuncture therapy may significantly improve the swallowing function of patients with dysphagia following cerebral infarction. |
| I00-I99 Diseases of the circulatory system | Li(7) | 2019 | China | Cerebral infarction complicated with essential hypertension | 38/38; (20/18; 19/19) | 38/38; (20/18; 19/19) | 71±4;73±4/ 11.7±6.2;12.4±5.8(months) | Huoxue Sanfeng + Tiaohe Ganpi acupuncture(ST 9, LI 4, LI 11, ST 36, LR 3), 30 min, once a day, 5 times/week, 8weeks + basic treatment | Xingnao Kaiqiao acupuncture (30 min, once aday, 5 times/week, 8weeks) and nifedipin(30ml ,once a day) | 1) Changes of blood pressure 2) Blood pressure variability | NR | Huoxue Sanfeng and Tiaohe Ganpi acupuncture method can effectively control the blood pressure and blood pressure variability in the elderly patients with cerebral infraction complicated with essential hypertension. |
| I00-I99 Diseases of the circulatory system | Li(8) | 2019 | China | Cricopharyngeal achalasia | 15/15/15/15/15/15; (7/8; 8/7; 9/6; 7/8; 8/7; 8/7) | 15/15/15/15/15/15; (7/8; 8/7; 9/6; 7/8; 8/7; 8/7) | 57±7;57±8;57±8;60±6;58±8;56±8/ 2.2±1.1;2.5±1.4;2.5±1.8;2.9±2.6; 2.4±1.1;2.5±1.6(months) | 1) Catheter balloon dilation, once a day, 5 times/week, 10times/course, 6course(B) 2) Acupuncture in local area(GB 20, GB 12, TE 17, three-tongue points (Extra), 30min, once a day, 5 times/weeks, 10 times/course, 6course(C1) 3) Acupuncture based on zangfu differentiation(PC 6, HT 5, ST 36, SP 6, 30min, once a day, 5 times/weeks, 10 times/course, 6course(C2) group C3 (treated with acupuncture at the local area and the acupoints based on zangfu differentiation) -Fengchi (GB 20), Wangu (GB 12), Yifeng (TE 17) and three-tongue points (Extra),Neiguan (PC 6), Tongli (HT 5), Zusanli (ST 36) and Sanyinjiao (SP 6) group D (catheter balloon dilation + the optimal acupuncture) | Routine treatment, once a day, 5 times/week, 10 times/course, 6 course. | 1) Feeding-swallowing function grade 2) VFSS | NR | In the study of the different acupuncture methods, the acupuncture at the local acupoints and the acupoints selected based on zangfu differentiation is the optimal acupuncture regimen for cricopharyngeal achalasia after brain stem infarction. The catheter balloon dilation combined with acupuncture present the synergistc effect on cricopharyngeal achalasia after brain stem infarction, obviously relieve dysphagia and reduce aspiration. |
| I00-I99 Diseases of the circulatory system | Liang | 2020 | China | Ventricular Premature Contraction | 76/68; NR | 71/65; (33/38; 32/33) | 65±12;62±11/NR | Dingji Fumai Decoction (1200mg tid) + metoprolol(12.5mg bid), 12w | Placebo(1200mg, tid) + Metoprolol(12.5mg bid) | 1) Composite of clinical symptoms and signs: traditionalChinese medicine syndrome score 2) Number of VPC 3) Adverse events, medication compliance, laboratory examination | None | Superiority with DFD arm for VPC was demonstrated over MET arm for both the safety and effectiveness end points. |
| I00-I99 Diseases of the circulatory system | Liu(2) | 2019 | China | Post-stroke aphasia | 34/34; (18/16; 20/14) | 34/34; (18/16; 20/14) | 56±5;57±5/ 3.2±1.3;3.3±1.4(d) | Xingnao kaiyin acupuncture+basic therapy and speech rehabilitation exercises GV 26, PC 6, SP 6, CV 23, GV 20, GV 16, GV 15, LI 4, LR 3 once a day, 6 times/week, 4weeks/course, 2 course | Basic therapy and speech rehabilitation exercises, 40min, once a day, 6day/week. 4weeks/course, 2course + Schuell’s aphasia stimulation therapy | 1) Speech function scores (comprehension, naming, retelling, writing and reading) | NR | Based on the basic treatment and speech training, “Xingnao kaiyin acupuncture” could improve the early rehabilitation effect of post-stroke aphasia |
| I00-I99 Diseases of the circulatory system | Lu | 2019 | China | Hemorrhagic transformation | 106/106; (61/45; 65/41) | 106/106; (61/45; 65/41) | 64.1±8.4; 63.6±7.4/ 3.45±0.38; 3.52±0.36(hrs) | Modified Buyang Huanwu Decoction 14days+ rt－PA intravenous thrombolysis,14 days | rt－PA intravenous thrombolysis,14 days | 1) Neurological deficit score 2) Serum matrix metalloproteinase-9(MMP-9) 3) Neuron specific enolase (NSE) 4) Vascular endothelial growth factor (VEGF) 5) Plasma cellular fibronectin (c-FN) levels 6) Incidence of hemorrhagic transformation 7) Clinical efficacy and adverse drug reactions | NR | Modified Buyang Huanwu Decoction could reduce the expressions of MMP－9,c-FN,NSE and VEGF after rt-PA intravenous thrombolysis in patients with super early cerebral infarction,and decrease the hemorrhagic transformation rate after thrombolysis,with high safety |
| I00-I99 Diseases of the circulatory system | Miao | 2020 | China | Poststroke | 20/22; NR | [AIA upper/AIA lower/CT upper/CT lower] 11/16/12/16; (10/1; 13/3; 7/5; 11/5) | 62.23±13.44;59.25 ±16.14; 65.22±11.14;70.60±8.55/ 15.0;18.5;17.5;11.0 | Auricular intradermal acupuncture (AT3 (occiput)-AT2 (temple)-AT1 (forehead), located in the antitragus zone. SF4, 5 (shoulder)-SF6 (clavicle), SF3 (elbow)-SF2 (wrist)-SF1 (finger), located in the scaphe zone AH7 (gluteus)-AH6 (sciatic nerve), AH5 (hip)-AH4 (knee), AH4 (knee)-AH3 (ankle)-AH2 (toe), located in the antihelix zone 6 sessions/week, 1 w) + conventional treatment | Conventional treatment(CT) + Rehabilitation + Routine Acupuncture(LI15, LI11, LI10, LI4, SJ5, GB30, GB34, ST36, ST41, BL60) | 1) Fugl-Meyer Motor Assessment - extensor synergy movement (FSM and ESM) of the upper and lower extremities (UE and LE) | 7 patients who underwent AIA experienced slight bleeding after needle penetration. No other adverse events related to acupuncture occurred. | AIA is useful for motor rehabilitation in poststroke patients, particularly in terms of improving extensor synergy. |
| I00-I99 Diseases of the circulatory system | Shao | 2019 | China | Post-stroke hemiplegia | 29/28; (16/13; 13/15) | 29/28; (16/13; 13/15) | 56.17 ±9.23; 57.21 ±8.72/ 67.28 ±39.14; 65.50 ±43.00 | Fuzhengbutu acupuncture–moxibustion therapy(every morning, 5 times/week, 4 weeks) + rehabilitation treatment(once every afternoon, 5 times/week, 4 weeks) | Rehabilitation treatment, 5 times/week, 4 weeks | 1) PIERENSTEP system 2) Berg balance scale | NR | Based on rehabilitation treatment, Fuzhengbutu acupuncture.moxibustion therapy effectively improves the walking function of the patients with hemiplegia after ischemic stroke. |
| I00-I99 Diseases of the circulatory system | Shao | 2019 | China | After Out-of-Hospital Cardiac Arrest | 599/602; (457/142; 434/168) | 599/602; (457/142; 434/168) | 66±15;66±16/NR | Shenfu injection (SFI) + standard treatment with epinephrine | Standard treatment(Epinephrine) | 1) Survival to hospital admission 2) Return to spontaneous circulation (ROSC) 3) Survival to hospital discharge 4) Favourable neurological outcome at discharge 5) Survival to one year 6) Favourable neurological outcome at one-year survival | None | The combination of SFI and epinephrine had favourable neurological outcomes after OHCA compared with those with epinephrine alone, whereas the survival to admission was not significantly altered. |
| I00-I99 Diseases of the circulatory system | Song | 2018 | China | Acute ischemic stroke(AIS) after endovascular intervention examination | 61/60; (33/31; 32/28) | 61/60; (33/31; 32/28) | 59.15±13.76;60.78±12.13/NR | Sanhuang Xiexin decoction(100 ml, bid, 7d) + basic treatment (SX group) | Basic treatment | 1) Fasting fibrinogen 2) PAgT (platelet aggregation test) 3) CRP (C-reactive protein) 4) TMAO (trimethylamine oxide) 5) Syndrome of fire-heat scores | NR | The prescription of Sanhuang Xiexin is efficient and safe in the treatment of AIS patients after endovascular intervention examination through reducing the inflammatory factors. |
| I00-I99 Diseases of the circulatory system | Vilaval | 2019 | Thailand | Hypertensive patients | 40/40; NR | 40/40; NR | nr | Acupuncture(SP 9, ST 36, LR 3, LI 4, LI 11, PC 6, 30 min, once per week, 8w)+ medication | Amlodipine, 5 mg | 1) Systolic Blood Pressure 2) Diastolic Blood Pressure 3) Mean arterial Blood Pressure | No serious adverse events were reported. Only 2 patients had minimal bleeding and pain. | These results indicate that the effectiveness of acupuncture with the acupuncture group is superior to the only medication group in the control of hypertension. |
| I00-I99 Diseases of the circulatory system | Wang(6) | 2019 | China | Chronic heart failure | 80/80; NR | 74/70; (42/32; 48/22) | 68.58±8.42;68.14±8.73/NR | Shenfu injection (SFI) + standard medications (50 ml SFI + 100 ml GS) 7 ± 1 days | Placebo(150 ml glucose) + Standard medications | 1) New York Heart Association (NYHA) 2) Traditional Chinese Medicine (TCM) scores 3) Lee’s CHF scores, 6-minute walk distance (6MWD), LVEF, and the incidence rate of cardiovascular events and heart failure emergency)rehospitalization 4) Safety: tests of blood, urine, stool, the levels of serum K,Na, Cl, ALT, aspartate aminotransferase (AST), blood urea nitrogen (BUN), and Cr, and the occurrence of adverse events (AEs))adverse drug reactions (ADRs). | The incidence of adverse events and other safety indices showed no significant differences between the two groups | SFI combined with conventional therapy for treatment of CHF during acute symptom aggravation ameliorated the cardiac dysfunction and clinical symptoms and improved the patients’ quality of life without any significant AEs compared with the conventional therapy alone. |
| I00-I99 Diseases of the circulatory system | Wang(8) | 2019 | China | Limb Spasticity in Patients Following Hemorrhagic Stroke | 30/29; (19/11; 16/13) | 30/29; (19/11; 16/13) | 56.7±7.02 59±7.51 / 59.53±17.49 55.72±15.78 | Acupuncture treatment(GV20, EX-HN5, BL37, BL38, GB33, GB34, ST36, ST38, LR3) + conventional treatment, 24 sessions, | Conventional treatment | 1) Modified Ashworth Scale (MAS) 2) Short intracortical inhibition (SICI) 3) Hmax)Mmax ratio 4) Fugl-Meyer Assessment (FMA) 5) Barthel Index (BI) 6) Motor evoked potential (MEP) 7) Surface integrated electromyogram (IEMG) | None | Acupuncture could improve the lower limb spasticity and motor function, thus providing a safe and economical approach for treating stroke patients. The potential mechanism underpinning the greater improvement may be attributed to a reshape of corticospinal plasticity induced by acupuncture. |
| I00-I99 Diseases of the circulatory system | Wu(7) | 2019 | China | Post-stroke dysphagia | 65/63; (37/28; 35/28) | 65/63; (37/28;35/28) | 44.00±2.92/44.35±2.60; 3.93±0.12w/3.67±0.36w | Relieving throat and opening orifice acupuncture therapy (Main acupoints: EX-HN 1, GV20, EX-HN5, bilateral GB 20, Shesanzhen; Electrostimulator on EX-HN 1, bilateral GB20, Shesanzhen; 30 min/session, 5 times/week, 3w/cycle, 2 cycles) | Rehabilitation trainings | 1) Deglutition ability scale (developed by Fujishima Ichiro) 2) Assessment of therapeutic effects | NR | The acupuncture therapy for relieving throat and opening orifice combined with deglutition training achieves the satisfactory therapeutic effects on dysphagia induced by cortical infarction in stroke. However, a large sample and multicentral clinical trial with this therapy is needed for a further argument so that this therapy is likely promoted in clinical practice in future. |
| I00-I99 Diseases of the circulatory system | Xin | 2019 | China | Chronic heart failure | 70/70; (41/29; 43/27) | 70/70; (41/29; 43/27) | 54.62±5.32;52.42±5.64/ 6.15±1.24;6.21±1.04 | Linggui zhugan decoction(200 ml/day, 2 weeks) + urosemide, metoprolol, spironolactone, isosorbide mononitrate, trimetazidine, irbesartan | Urosemide, metoprolol, spironolactone, isosorbide mononitrate, trimetazidine, irbesartan | 1) Serum inflammatory factors 2) Immune function 3) Cardiac function 4) Clinical effectiveness | NR | These results suggest that co-administration of decoction of Linggui zhugan and western medicine improves ventricular function and reduces clinical symptoms in patients with CHF via a mechanism involving inhibition of inflammatory reactions. |
| I00-I99 Diseases of the circulatory system | 2019 | China | Ischemic stroke | 50/50 | 48/49; (38/10; 38/11) | 67.0±7.2;66.9±7.3/ 28.1±3.4;28.1±3.5(d) | Manual acupunctur(GV 14, GV 16, GV 24, GV11, GV 20, GV 26), once a day, 5 times/week, 4weeks | Swallowing training (including tongue extending and retracting,cheek-muscle training,breathing exercise,and laryngopharyngeal exercise,begining from the 2nd day after hospitalization) | 1) Video fluoroscopic swallowing study)(VFSS) 2) Kubota water swallowing test 3) Standard swallowing function assessment (SSA) 4) Swallowing releted quality of life questionnaire(SWAL-QQL) 5) Cerebtal hemodynamics(mean blood flow velocity, maximum peak flow speed, and vascular resistance index of the bilateral cerebral arteries) | NR | Tongdu Tiaoshen needling combined with swallowing training is effective in improving swallowing ability promoting cerebral blood flow and in up regulating serum neurotrophic factor levels in patients with dysphagia after ischemic stroke. | |
| I00-I99 Diseases of the circulatory system | Xiong | 2019 | China | Ischemic stroke patients undergoing carotid artery stenting | [EA/TEAS/Sham ] 46/45/45); NR | 41/42/41; (31/10; 31/11; 30/11) | 67±4;67±5;66±4/NR | 1) Electro-acupuncture (EA, GV 26, GV 20, LI4, TE 5, 30 min before surgery until the end of the operation) 2) Transcutaneous electrical acupoint stimulation (TEAS) | Sham EA | 1) Cerebral blood flow (CBF) 2) Hyperperfusion incidence and neurological function - National Institutes of Health Stroke Scale (NIHSS), General Evaluation Scale (GES) | Mild pain or bleeding after EA treatments, No other serious adverse events. | EA or TEAS administered in combination with local anesthesia during CAS can inhibit transient increases in CBF, reduce the incidence of postoperative hyperperfusion, and improve neurological function. |
| I00-I99 Diseases of the circulatory system | Xiong | 2020 | China | Stroke on cognitive and motor functions during the recovery stage | 36/36; NR | 35/35; (20/15; 17/18) | 63.0±7.23;65.3±8.52/2.13±0.85;2.51±0.46 | 1) Scalp acupuncture(GV 20, EX-HN1, GB 20, GV 24) + cognitive training, six times/week, 8 weeks | Sham scalp acupuncture + cognitive training | 1) Mini Mental State Examination (MMSE) 2) The Loewenstein Occupational Therapy Cognition Assessment (LOTCA) 3) The Fugl-Meyer assessment (FMA) 4) The Modified Activity of Daily Living Scale (mADL) 5) The plasma BDNF and NGF levels | NR | Combined scalp acupuncture and cognitive training can efficiently enhance cognitive and motor functions in patients with stroke during the recovery stage, which may be a more effective rehabilitation treatment after stroke than routine therapy and rehabilitation training alone |
| I00-I99 Diseases of the circulatory system | Xu | 2019 | China | Coronary heart disease | 30/28; (20/18; 18/10) | 30/28; (20/18; 18/10) | 66.8±7.6;66.5±9.7/5.4 ±1.3;5.1±1.4 | B-receptor blocker, statins, and antiplatelet medications+ Huoxin formula(bid, 3months) | B-receptor blocker, statins, and antiplatelet medications | 1) Safety indexes (blood, urine, liver and kidney functions, blood lipids, blood glucose, glycosylated haemoglobin, UCG, ECG) 2) Effect indexes (hs-CRP, IL-18, IL-17, TNF-a, MMP-9, CAVI, ABI, IMT, pulse pressure) | no reported adverse events related to the Huoxin formula | Since the Huoxin formula improved arterial functions and reduced inflammatory factor activities in CHD patients, a large-scale clinical trial is warranted. |
| I00-I99 Diseases of the circulatory system | Xue | 2019 | China | Chronic heart failure | 50/50; (29/21; 27/23) | 50/50; (29/21; 27/23) | 63.8±9.46;64.3±7.78/ 906.7±821.5;692.9±600.8 | Standard treatment+ Xinmailong injection (100 mg/2 mL, intravenous drip infusion, 5 days) | Standard treatment + equal amounts of XI placebo | 1) New York Heart Association (NYHA) functional class 2) LVEF 3) BNP 4) 6-min walking distance | The number of adverse events recorded was similar between the two groups ( p > 0.05). Skin itching: twice in two patients in the XI group evelated WBC: two cases twice in the control group | XI can alleviate the symptoms, improve heart function, and exercise tolerance in patients with CHF and is safe to use |
| I00-I99 Diseases of the circulatory system | Yin | 2019 | China | Persistent atrial fibrillation | 40/45; (25/15 ; 28/17) | 40/45; (25/15 ; 28/17) | 61.6±10.6;62.6±9.1/ 14.2±17.0;21.1±29.1 | Acupuncture(Neiguan, 7 days) + amiodarone after pulmonary vein isolation (PVI) | Amiodarone | 1) Levels of inflammatory factors 2) Incidence of early recurrences of AF | NR | Neiguan point acupuncture combined with amiodarone is superior to amiodarone alone in reducing early recurrences of patients with persistent AF after PVI. The efficacy of Neiguan acupuncture therapy on the early recurrence is associated with the decreased inflammation factors. |
| I00-I99 Diseases of the circulatory system | You | 2019 | China | ST-segment elevation myocardial infarction at a high risk of no-reflow during primary percutaneous coronary intervention | 57/53; (48/9; 47/6) | 57/53; (48/9; 47/6) | 56.8±8.9;55.4±9.5/NR | Danhong injection (DI) | Physiologic saline | 1) Myocardial infarct size (IS) imaged on delayed-enhancement CMR 2) Major adverse cardiac events | The prevalence of major cardiovascular adverse events in the DI group were lower than that in the control group. | application of DI can reduce the myocardial infarct size in STEMI patients at a high risk of NR during primary PCI. |
| I00-I99 Diseases of the circulatory system | Yu(2) | 2019 | China | Chronic Heart Failure | 50/50; (29/21; 27/23) | 50/50; (29/21; 27/23) | 63.8±9.46;64.3±7.78/ 906.7±821.5;692.9±600.8 | Standard treatment+ Xinmailong injection (100 mg/2 mL, intravenous drip infusion, 5 days) | Standard treatment + equal amounts of XI placebo | 1) New York Heart Association (NYHA) functional class 2) LVEF 3) BNP 4) 6-min walking distance | The number of adverse events recorded was similar between the two groups ( p > 0.05). Skin itching: twice in two patients in the XI group evelated WBC: two cases twice in the control group | XI can alleviate the symptoms, improve heart function, and exercise tolerance in patients with CHF and is safe to use. |
| I00-I99 Diseases of the circulatory system | Yu(3) | 2019 | China | Chronic heart failure with syndromes of deficiency of heart Yang | 39/37; NR | 33/30; (18/15; 16/14) | 52.0±21.0;50.1±20.2/NR | Standard medications+ Jiawei Shenfu decoction(one dose daily, 4 weeks) | Standard medications | 1) Heart syndrome scores, heart rate, 6MWD, LVEF 2) Cytokines: plasma B-type natriuretic peptide (BNP), NF-κB, TNF-α level | NR | Routine medicine combined with Jiawei Shenfu decoction for patients with heart Yang deficiency syndrome in chronic heart failure can improve the left ventricular ejection fraction and cardiac function, and reduce BNP levels. The mechanism may be related to inhibition of pro-inflammatory cytokines and the NF-κB-induced kinase pathway, leading to amelioration of the inflammatory response. |
| I00-I99 Diseases of the circulatory system | Zhang(7) | 2019 | China | Rehabilitation in patients received coronary artery bypass grafting | 83/83; NR | 83/83; (70/13; 69/14) | 60.55±9.65;61.69±8.60 | Shenmai injection (100 ml/day) right after the surgery to discharge for 9.28 ± 3.75 days and then capsule (3.6 g/day) sequentially for 30 days + cardiac rehabilitation | Cardiac rehabilitation | 1) 6-Minute Walking Test 2) Perioperative and follow-up mortality, MI, stroke, reoperation, the length of stay in ICU, the duration under the mechanical ventilation and the length of stay after the operation in hospital | None | Shenmai improves the exercise tolerance in the early stage of the cardiac rehabilitation for patients received coronary artery bypass grafting. |
| I00-I99 Diseases of the circulatory system | Zhao(4) 2019 China | 2019 | China | Chronic Stable Angina | 99/99/101/99; (35/64; 32/67; 39/62; 39/60) | 99/99/101/99; (35/64; 32/67; 39/62; 39/60) | 62.5±9.9;61.8±9.8; 62.4±8.9;63.4±10.3/ 46.2±47.9;59.9±84.3; 51.3±51.1;61.5±69.3 | 1) Acupuncture on the acupoints on the disease-affected meridian (DAM, PC6, HT5) 2) Acupuncture on the acupoints on the nonaffected meridian (NAM, LU9, LU6) 3) Sham acupuncture (SA), 3 times weekly for 4 weeks for a total of 12 sessions | No acupuncture(wait list [WL]) | 1) Frequency of angina attacks 2) Mean severity of angina: visual analog scale 3) Seattle Angina Questionnaire 4) Rescue medication intake 5) 6-minute walk distance test 6) Zung self-rating anxiety scale 7) Self-rating depression scale 8) Heart rate variability | All AEs were reported as mild or moderate; none required special medical interventions. Only 1 patient in the WL group experienced a serious AE. | Compared with acupuncture on the NAM, SA, or no acupuncture (WL), acupuncture on the DAMas adjunctive treatment to antianginal therapy showed superior benefits in alleviating angina. |
| J00-J99 Diseases of the respiratory system | Cui | 2019 | China | Mycoplasma pneumoniae infection and asthma in children | 42/42; (26/16; 24/18) | 42/42; (26/16; 24/18) | 4.3±2.3;4.5±2.1/7.51±1.32;7.32±1.14 | Reduning injection (RDN)+ azithromycin + routine care, 7 days | Azithromycin(10 mg, qd, 7 days) + routine treatment | 1) Time to defervescence 2) The time to the disappearance of shortness of breath 3) Cough and lung rales 4) The length of the hospital stay 5) The overall response rate 6) The incidence of adverse events 7) The eosinophil count (EOS) 8) Eosinophil cationic protein (ECP) 9) Interleukin-8 (IL-8) 10) Pulmonary function: forced vital capacity (FVC), forced expiratory volume in one second (FEV1), peak expiratory flow (PEF) | There was no statistically significant difference in the incidence of adverse events between the two groups | RDN combined with azithromycin is effective in treating children with mycoplasma pneumoniae infection and asthma, which can significantly improve their clinical symptoms and pulmonary function, and shorten their hospital stays. The combination also has a lower incidence of adverse events and a favorable safety profile. Therefore, it is worthy of popularization in clinical practice. |
| J00-J99 Diseases of the respiratory system | Kawago | 2019 | Japan | Aspiration Pneumonia in Patients Undergoing Cardiovascular Surgery | 16/18; NR | 13/17; (10/3; 14/3) | 65.2±13.9;69.2±13.0/NR | Hangekobokuto (HKT, tid, POD1-14) | Placebo (7.5 g, tid, POD1-14) | 1) Prevention of postoperative aspiration pneumonia 2) Complete recovery from swallowing and coughing disorders | NR | HKT can prevent aspiration pneumonia in patients undergoing cardiovascular surgery. In high-risk patients for aspiration pneumonia, HKT can prevent aspiration pneumonia and improve swallowing disorders. |
| J00-J99 Diseases of the respiratory system | Liu(3) | 2019 | China | Diaphragmatic dysfunction associated with mechanical ventilation | 26/26; (23/2; 23/3) | 26/26; (23/2; 23/3) | 70±8;73±11/ NR | Acupoint electrical stimulation therapy(LR3, SP21, BL20, BL23, 30min, 3 times/day, 7 days) + Conventional treatment | Conventional treatment | 1) Diaphragm thickening fraction (TFdi) 2) Mechanical ventilation time 3) ICU time 4) Total hospitalization time 5) Hospital mortality 6) Reintubation rate | NR | Ultrasound-guided acupoint electrical stimulation can relieve ventilator-induced diaphragmatic dysfunction, reduce ventilator support time and reintubation events. |
| J00-J99 Diseases of the respiratory system | Lu(3) | 2019 | China | Postoperative sore throat | 480/400; (236/244; 257/143) | 480/400; (236/244; 257/143) | 47.1± 11.1; 48.6 ± 12.9/ NR | Plasters were applied to the designated points (Tianzhu, Lianquan, Dazhui, etc) | 1) Arterial pressure (MAP), heart rate (HR), and blood oxygen saturation (SpO2) 2) Occurrence of choke cough at T2 3) Amount of sputum and the sputum pH 4) Postoperative Nausea and vomiting 5) Severity of sore throat 6) Operation time and the recovery time | NR | In this study, acupoint application was used, providing a simple, safe, efficient, and durable approach to prevent and treat respiratory tract complications after operation under general anesthesia. | |
| J00-J99 Diseases of the respiratory system | Lyu | 2020 | China | Acute tonsillitis | 48/48/48; NR | 47/48/46; (18/29; 22/26; 16/30) | 63.86;73.73;75.45/NR | 1) Reyanning Mixture, 20 mL, tid, 7d 2) Reyanning Mixture, 20 mL, tid, 7d + Amoxicillin Capsules, 0.5g, tid, 7d | 3) Amoxicillin Capsules, 0.5g, tid, 7d | 1) Recovery time of the disease 2) Disappearance rate of fever | NR | According to the findings，when ＲYN was used alone in the treatment of acute tonsillitis，it was superior to Amoxil in time of recovery，short-term improvement of fever and redness and swelling of tonsil． Compared with ＲYN+Amoxil，there was no difference in cure rate of disease，recovery time of disease，body temperature recovery time，short-term improvement of fever，swelling of pharynx and swelling of tonsil，with a better efficacy than Amoxil． The clinical effect of ＲYN was similar to that of combined Amoxil in the treatment of acute tonsillitis，and ＲYN was superior to Amoxil in the time of recovery， short-term improvement of fever and redness and swelling of tonsil，with no adverse event or adverse reaction． ＲYN+Amoxil can significantly reduce the DDD value of antibiotics in the treatment of acute tonsillitis，with significant clinical advantages over Amoxil． |
| J00-J99 Diseases of the respiratory system | Popovych | 2018 | Ukraine | Acute non-bacterial tonsillitis | 118/120; (52/ 66; 62/58) | 114/110; (52/62; 54/56) | 8.67±3.219;9.66±3.296 | Phytoneering extract BNO 1030 + standard therapy: acute (first 5 days):: aged 6–11 years received 15 drops 6 times daily;children aged 12 years and over received 25 drops 6 times daily After alleviation (day 5 to 10): children aged 6–11 years received 15 drops 3 times daily, and children aged 12 years and over received 25 drops 6 times daily | Standard therapy | 1) Sore throat dynamics at rest and at swallowing 2) Throat irritation associated with cough 3) General condition 4) Day of withdrawal of antipyretics 5) Share of treatment responders 6) Therapeutic benefit from the use of BNO 1030 | None | BNO 1030 (Imupret®) is a safe and effective product for treatment of acute nonbacterial tonsillitis in children aged 6-18 years, assuring therapeutic benefit when prescribed additionally to the standard symptomatic therapy |
| J00-J99 Diseases of the respiratory system | Song(2) | 2019 | China | Pneumocomosts | 102/58; (53/49; 32/26) | 102/58; (53/49; 32/26) | 67.94±8.96;66.40±9.47/ 24.04±11.63;23.59±10.16 | Conventional treatment + TCM syndrome differentiation treatment (1 month) | Conventional treatment(Anti-infection, antispasmodic and antiasthmatic, relieve cough and expectorant, maintain acid-base balance, correct electrolyte imbalance) | 1) SF-36 Quality of Life Scale 2) C-reactive protein levels 3) the expression levels of IL一6 mRNA and TGF-B mRNA in serum | NR | TCM syndrome differentiation and treatment of pneumoconiosis can effectively improve the patient7S condition and life quality．We predict that it may inhibit the progression of pulmonary fibrosis in pneumoconiosis． |
| J00-J99 Diseases of the respiratory system | Wu | 2019 | China | Community Acquired Pneumonia | 86/86; NR | 86/86; NR | 36.18 ± 8.10;38.63 ± 7.09/ 4.65 ± 1.83;4.94 ±1.47(d) | Shufeng Jiedu capsule,2.08g/tim,3times/day,7days | Cefoperazone sodium and sulbactam sodium,2g in 250 ml NS,12h/time,7days | 1) Clinical efficacy 2) Improvement of clinical symptoms 3) Adverse reactions 4) Changes of serum indicators | NR | There were no adverse reactions in both groups． Shufeng Jiedu capsule combined with cefoperazone sodium and sulbactam sodium can significantly increase the clinical efficacy of CAP patients,improve their clinical symptoms,reduce inflammation and have high safety． It has clinical popularization significance. |
| J00-J99 Diseases of the respiratory system | Yang | 2020 | China | Senile community-acquired pneumonia with lung-spleen Qi deficiency syndrome | 30/30; (19/11; 20/10) | 30/30; (19/11; 20/10) | 68.25±6.75;67.51±6.57/NR | Qi-Wei-Bai-Zhu-San (QWBZS) + conventional therapy, 1 week | Conventional treatment (antibiotic therapy and symptomatic treatment) | 1) Treatment effects 2) Clinical signs: The time courses of the disappearances of cough, fever, and rale 3) Serum inflammatory factor 4) Th17/Treg 5) Arterial blood gas (ABG) marker 6) Pulmonary function marker levels | NR | QWBZS can signifi-cantly improve the clinical outcome in treating senile CAP with lung-spleen Qi deficiency syndrome, lower the Th17/Treg ratio in the peripheral blood, and improve the serum inflammatory marker levels. |
| J00-J99 Diseases of the respiratory system | Zhang(4) | 2020 | China | Chronic obstructive pulmonary disease patients combined with anxiety/depression | 64; NR | 30/32; (23/7; 23/6) | 71.23±6.57;71.50±6.99/NR | Acupoint catgut embedding(Zusanli (bilateral), Fenglong (bilateral), Feishu (bilateral), Pishu (bilateral), Shenshu (bilateral)) + standard of care and psychological intervention | Standard of care + psychological intervention | 1) TCM syndrome score 2) AECOPD and the number of severe AECOPD 3) 6 minute walk test 4) CAT score 5) TNF-α, IL-8 6) Psychological scale (SDS, SAS, SCL-90, SSRS) 7) FEV1 a nd FEV1)FVC | NR | Acupoint embedding therapy combined with psychological intervention can reduce the complications of COPD and improve the quality of life. |
| K00-K93 Diseases of the digestive system | Abbasi | 2019 | Iran | Constipation in patients undergoing hemodialysis | 37/37; NR | 35/35; (20/15; 16/19) | 60.3±12.5; 64.4±10.6/ nr | Acupressure(LI4, liv3, ST 36, SP15, and cv6, three times a week, four weeks) | Acupressure at false points | 1) Frequency of defecation | NR | Acupressure seems to be an effective complementary treatment for constipation in patients undergoing hemodialysis. |
| K00-K93 Diseases of the digestive system | Chung | 2019 | hongKong | Refractory functional dyspepsia | 66/66; (14/52; 20/46) | 66/66 (14/52; 20/46) | 50.8 ± 11.2; 47.6 ± 12.8/ 9.5 ± 9.3; 9.3 ± 10.0 | Electroacupuncture (EA, ST34, ST36, ST40, ST42, CV12, PC6, BL20, BL21, two sessions/week, 12w) + on-demand gastrocaine | Gastrocaine | 1) Binary assessment of adequate relief 2) Patient-reported global symptoms 3) Individual PDS symptoms (postprandial fullness and early satiation) 4) FD symptoms (epigastric Pain, epigastric burning, and postprandial nausea) 5) NDI 6) Nutrient Drink Test (NDT) 7) PHQ-9 8) GAD-7 | Adverse events were minimal and nonsignificant. | For refractory FD, EA provides significant, clinically relevant symptom relief when added to on-demand gastrocaine |
| K00-K93 Diseases of the digestive system | Dong | 2020 | China | Obese nonalcoholic fatty liver disease | 45/45; NR | 41/44; (20/21;24/20) | 35±8;37±9/ 5.3±4.3;5.1±4.3(yr) | Acupuncture therapy(CV 12, LI 11, CV 9, ST 24, SP 15, CV 4, CV 6) + Electroacupuncture therapy(ST 24, SP 15, 30 min/time, once every other day, 3 times /week,12weeks) | Lifestyle control | 1) Hepatic fat status 2) Glycolipid metabolism and insulin sensitivity 3) Anthropological parameters | NR | Electroacupuncture combined with lifestyle control can effectively treat obese nonalcoholic fatty liver disease, and present better therapeutic effect on hepatic fat status, glycolipid metabolism, insulin resistance, WC and WHR. |
| K00-K93 Diseases of the digestive system | Fitri | 2019 | Indonesia | Gastroesophageal reflux disease | 20/20; (2/18; 2/18) | 20/20; (2/18; 2/18) | 47; 41.5 | Acupoint-catgut embedment(CV12, ST36, BL21) + medication, every 15 days | Sham acupuncture+ medication | 1) Serum level of IL-6 | NR | The results suggest that catgut-embedding therapy has not been proven to statistically influence the levels of IL-6 in patients with GERD. |
| K00-K93 Diseases of the digestive system | Fu | 2019 | China | Hernia | 31/31/31; NR | 31/31/31; NR | [4-7] 5.2±1.4/5.1±1.2/5.2±1.3; 2.2±0.5/ 2.1±0.5/2.3±0.7(yr) [8-11] 8.5±1.7/ 8.5±1.4/8.6±1.8; 3.3±0.9/3.2±0.6/ 3.4±0.7(yr) [12-15] 12.6±1.8/ 12.7±1.7/12.8±1.5; 3.5±0.7/ 3.0±0.8/3.3±0.8(yr) | Auricular point(Shenmen, Jiaogan, Pizhixia, 30 min, 2 times/day, 3d) + electroacupuncture therapy (SP6, ST36, 20 min, 3 times/day, 3d) | Auricular point(Shenmen, Jiaogan, Pizhixia, 30 min, 2 times/day, 3d) | 1) Wong-Baker facial expression evaluation method | NR | Compared with auricular point pressing or EA alone, the combination of auricular point pressing and EA could not only effectively relieve the postoperative pain, but also reduce the expression of inflammatory cytokines in children with hernia, improving the clinical efficacy. |
| K00-K93 Diseases of the digestive system | Gülten | 2020 | Turkey | Postoperative care in patients undergoing laparoscopic cholecystectomy | 40/40; (14/26; 12/28) | 40/40; (14/26; 12/28) | 50.5±12.7; 51.7±12.5/NR | Acupuncture(ST36, LI4, PC6, EX1, 10 min before starting anesthesia induction) + usual care | Usual care + sham acupuncture | 1) Hemodynamic parameters 2) Visual analog scale 3) fFrst analgesic requirement 4) Total amount of analgesic requirement 5) Nausea-vomiting 6) Necessity for antiemetic medication | No major side effects of the acupuncture application were observed. Although hypotension was observed in 5 patients in the acupuncture group and 2 patients in the control group, the difference was not significant. | Acupuncture treatment reduces postoperative pain and nausea-vomitingincidence, antiemetic and analgesic requirements especially in the first 6 hours, and its combination with conventional postoperative treatment is effective and safe |
| K00-K93 Diseases of the digestive system | J | 2019 | China | Non-alcoholic fatty liver disease | 90/90; (53/ 37; 44/46) | 90/90; (53/ 37; 44/46) | 45.8±7.9;45.4±8/5.1±3.4;5.2±3.3 | Fructus akebiae extract + ursodeoxycholic acid(250mg, tid, 24 weeks) + exercise diet treatment | Ursodeoxycholic acid(UDCA, 250mg, tid, 24 weeks) + exercise diet treatment | 1) Clinical symptoms and signs 2) Non alcoholic fatty related indicators: CT, TG, TC, ALT, AST | NR | It can be seen that the addition of FAE can significantly improve the clinical symptoms and serum biochemical indicators such as ALT, AST, TG and TC in patients with non-alcoholic fatty liver disease, which is supported by some histological evidence. These findings suggest that FAE combined with Ursodeoxycholic Acid is safe and effective in the treatment of fatty liver. |
| K00-K93 Diseases of the digestive system | Kono | 2019 | Japan | Prolonged postoperative ileus after open abdominal surgery | 740; NR | 214/196; (138/76; 128/68) | 67.8;68.0/244.9;253.6 | Daikenchuto (DKT, 5g, orally, tid, 12d) | placebo | 1) Time from the end of surgery to the first bowel movement (FBM) | NR | The subgroup analysis showed that DKT significantly accelerated the recovery from prolonged POI following OAS. |
| K00-K93 Diseases of the digestive system | Liu(2) | 2020 | China | Hyperlipidemic acute pancreatitis | 20/20; (12/8; 13/7) | 20/20; (12/8; 13/7) | 39.3±3.6;40.8±4.4/NR | Modified Dachengqi decoction + conventional therapy | Conventional therapy | 1) Healing rate 2) Serum amylase, serum TG, and inflammatory index 3) Gastrointestinal function score and APACHE II total score 4) Syndrome differentiation results and treatment outcome of TCMs | NR | Modified Dachengqi decoction combined with conventional therapy has a better therapeutic effect on HLAP than conventional therapy. |
| K00-K93 Diseases of the digestive system | Ruan | 2019 | China | Recovery of Gastrointestinal Function after Gynecologic Laparoscopy | 80/80; NR | 80/80; NR | 39.5±8.9;38.2±9.4/NR | Acupoint massage(Zusanli, Neiguan, Zhongyu, Sanyinjiao, 3 times/day, until the first anal exhausted was restored) + standard care | Postoperative nursing | 1) Recovery time of bowel sounds 2) The first anal exhaust time and the first defecation time 3) The plasma levels of motilin, somatostatin and cholecystokinin | NR | Acupoint massage could accelerate the recovery of bowel function after gynecologic laparoscopy by modulating the release of gastrointestinal hormones |
| K00-K93 Diseases of the digestive system | Song | 2019 | China | Prolapsed and hemorrhoids | 30/30; (16/14; 15/15) | 30/30; (16/14; 15/15) | 40±12;40±12/7.9±5.0;7.9±5.0(yr) | Acupuncture(Baliao, 30 min before PPH + Electroacupuncture(BL 32, BL 34, 30min) | Routine treatment | 1) The scores of anal pendant 2)Pain degree 3) Persistent time 4) First urination time | NR | Electroacupuncture at Baliao point 30 min before PPH can not only decrease the degrees of anal pendant and pain in the 6 h, 12 h, 18 h, but also shorten the persistent time of anal pendant and pain within 24 h after surgery and promote the first urination. |
| K00-K93 Diseases of the digestive system | Takeuchi | 2019 | Japan | Proton pump inhibitor-refractory gastroesophageal reflux disease | 42/36; NR | 38/33; (10/28; 11/22) | 59.2±14.7;60.8±14.7/NR | Usual dose of rabeprazole (10 mg/day) + HST (7.5 g/day), 4 weeks | Double dose of Rabeprazole (PPI)(20 mg/day) | 1) Improvement in FSSG (Frequency Scale for the Symptoms of GERD) 2) Change over time in FSSG score | HST(6/38), PPI(1/33): soft stool, nausea, elevated ALP, elevated c-GTP, elevated AST, elevated ALT, and abnormal liver function. | HST may be beneficial for patients with PPIrefractory GERD, particularly in non-obese and nonelderly patients with dyspepsia symptoms. |
| K00-K93 Diseases of the digestive system | Tang | 2019 | China | Irritable bowel syndrome with predominant diarrhea | 171/171; (85/86; 93/78) | 171/171; (85/86; 93/78) | 43.97±13.82;45.59±12.81/ 24.22±23.04;25.93±35.27 | Tongxiening Granules (TXNG) (5 g per time) + pinaverium bromide Tablet simulator(50 mg per time), tid, 6w | TXNG simulator (5 g per time) + pinaverium bromide Tablets (50 mg per time) | 1) Irritable Bowel Syndrome Symptom Severity Score (IBS-SSS) 2) Adequate relief (AR) rate 3) Irritable Bowel Syndrome-Quality of Life Questionnaire (IBS-QOL) 4) Hamilton Anxiety Scale (HAMA) 5) Hamilton Depression Scale (HAMD) 6) Recurrence rate | A total of 21 AEs occurred in 15 cases, of which 11 occurred in 8 cases in the treatment group and 10 AEs in 7 cases in the control group. The incidence of AEs had no statistical signififi cance between the two goups (P>0.05). | Tongxiening Granules could relieve the symptoms of patients with IBS-D and the treatment effect was comparable to pinaverium bromide. |
| K00-K93 Diseases of the digestive system | Wang(2) | 2020 | China | Laryngopharyngeal reflux | 42/42; NR | 42/42; NR | NR | Acupuncture treatment(CV 22, CV 17, CV 12, ST 36, LR 3, PC 6, once a day, 5 times/week, 10 times) + oral medication | Esomeprazole tablets (20 mg, twice a day) + mosapride tablets (5 mg, three times a day), 14 days | 1) Reflux symptom index (RSI) score 2) Reflux finding score (RFS) 3) Time proportion of esophageal pH<4 | NR | On the base of the conventional treatment, acupuncture at the acupoints composed in compliance with the theory of the ascending and the descending of qi combined with western medication contribute to the recovery of gastrointestinal function, effectively control the laryngopharyngeal symptoms and physical signs. The therapeutic effect of this comprehensive therapy is better than the simple treatment with western medication. |
| K00-K93 Diseases of the digestive system | Xue(1) | 2019 | China | Diarrhea-predominant irritable bowel syndrome | 58/58; (20/38; 16/42) | 58/58; (20/38; 16/42) | 11.1 ± 2.7; 11.3 ± 2.5; / 1.1 ± 0.3; 1.0 ± 0.8 | Acupuncture therapy of Traditional Chinese Medicine (Yintang, bilateral Taichong, bilateral Zusanli, bilateral Tianshu, Baihui bilateral Sanyinjiao acupoint, and bilateral Shangjuxu, 30 min, 5 times/w, 4w) + Astragalus injection | Astragalus injection, 4 weeks | 1) The therapeutic effects. 2) 5-hydroxytryptamine (5-HT) 3) Neuropeptide Y (NPY) 4) Calcitonin gene-related peptide (CGRP) | NR | Acupuncture therapy of TCM combined with Astragalus injection has a satisfactory effect in the treatment of children with diarrhea-predominant IBS, which is worthy of more publicity and application in the clinic. |
| K00-K93 Diseases of the digestive system | Yang(2) | 2020 | China | Patients undergoing thoracoscopic segmentectomy/lobectomy | 30/29; NR | 29/28; (13/16; 18/10) | 58.93±11.77;56.39±9.34/100;97.5 | Electroacupuncture (PC6, ST36, ST37) + usual care, 24 hours before surgery, 4 hours and 24 hours after surgery | Usual care | 1) Recruitment, retention, acceptability of the EA intervention 2) Incidence and severity of abdominal distension (AD) 3) Time to first flatus and defecation 4) Postoperative nausea and vomiting (PONV) 5) Pain intensity 6) Duration of hospital stay. | There were no serious EA-related adverse events reported throughout the study. The most commonly reported adverse events were hematoma, sleeplessness, and mild or transient sharp pain. | EA is feasible and acceptable to patients undergoing VATS surgery. Our preliminary findings of EA promoting postoperative recovery of gastrointestinal function warrants large randomized controlled trials |
| K00-K93 Diseases of the digestive system | Zhan | 2020 | China | Postoperative analgesia | 30/30/30; (15/15; 15/15; 18/12) | 30/30/30; (15/15; 15/15; 18/12) | 58.4±13.8;64.6±14.6; 59.6±12.2/ 174.6±32.7;176.6±34.9; 174.2±36.3 | 1) Transverse abdominis plane block (TAP) 2) TAP+ transcutaneous electric acupoint stimulation (frequency of 2-100 Hz, ST36, PC6) | Usual care | 1) Visual Analogue Scale (VAS) 2) Postoperative adverse reactions, hemodynamic effect(Blood pressure and heart rate, nausea, vomiting, dizziness) | TAP+TEAS group showed significant lower incidence of postoperative adverse reactions compared with the other two groups. | TAP combined with TEAS can improve postoperative analgesic effect and decrease the incidence of postoperative adverse reactions. |
| K00-K93 Diseases of the digestive system | Zhang(2) | 2020 | China | Alveolar bone mass in postmenopausal women with periodontitis | 45/45/45; NR | 45/45/45; NR | 49.12±5.61;49.33±6.93;49.61±7.02/ NR | 1) Xianling Gubao Capsule(1.0 g/time, 3 times per day, 3 months/cycle, 2 cycles) +Baseic treatment | 2) Blank group : basic treatment (performed to eliminate plaque and calculus by cleaning and curing the gums, and smoothing the root surface, once 3 months for 6 continuous months) 3) Control group: basic treatment+vitamin D(oral Calci-D (600 mg of calcium and 125 U of vitamin D per tablet), 1T qd, 6 months) | 1) Cone-beam CT (bone mineral density and height of alveolar bone defect) | NR | The treatment of periodontitis by xianling Gubao CapsuIe can siqnificantly improve the alveolar bone defect height and bone mineraI density,and cone-beam CT can be used to evaIuate its clinical efficacy.． |
| K00-K93 Diseases of the digestive system | Luo | 2020 | China | Postoperative intestinal function recovery | 92/92; NR | 91/90; (52/39; 47/43) | 58.0±10.2;60.0±10.1/234.0±67.6;231.1±61.6 | Low-frequency ultrasound and electric pulses for transdermal drug delivery with Dachengqi Decoction (DCQD) | Conventional treatment | 1) Time to first flatus after surgery 2) Recovery time of bowel movement, time of the first defecation, postoperative gastrointestinal complications, days of hospitalization and treatment costs. | There were no significant differences in the occurrence rates of AEs or SAE, days of hospitalization and treatment costs between the two groups. | Low-frequency ultrasound and electric pulses for transdermal drug delivery with DCQD can shorten the time of bowel movement recovery and accelerate first anal exhaust after laparoscopic gastrointestinal surgery. |
| L00-L99 Diseases of the skin and subcutaneous tissue | Gao(2) | 2019 | China | Anal eczema | 61/61; (31/30; 32/29) | 61/61; (31/30; 32/29) | 38.32±3.67/41.21±2.93; 1.31±0.11/1.29±0.29(yr) | Triamcinolone acetonide acupoint injections + Kugan mixture fumigation treatment, 4w | Mormisone furoate cream,1 month | 1) Lesion area score - levels of serum IL-2, IL-4, IL-6, and Gas 2) Clinical syndrome score changes - pruritus, exudation, burning, rash, upset, thirsty, yellow urine, and dry stool | NR | The curative efficacy of triamcinolone acetonide acupoint injection combined with compound Kugan mixture on the treatment of anal eczema is evident. Moreover, the tolerance is good, and the purpose of treating the perianal eczema of the patient can be achieved by improving the serum IL-2, IL-4, IL-6, and Gas levels |
| L00-L99 Diseases of the skin and subcutaneous tissue | Jowkar | 2019 | Iran | Vitiligo | 20/20; NR | 17/17; NR | 33.1±11.6;35.7±16.2/8.4±11.9;8.5±7.2 | NBUVB + silymarin, bid, 3 months | NBUVB + placebo | 1) Vitiligo area severity index (VASI) | NR | This study showed that probably Silybum marianum is a good choice for patients with vitiligo; however, further studies are recommended to be conducted to confirm our result. |
| L00-L99 Diseases of the skin and subcutaneous tissue | Kou | 2020 | China | Acne vulgaris | 30/33; NR | 30/33; NR | NR | Acupuncture + conventional treatment [Wind-heat syndrome] Hegu, Quchi, Chize, Weizhong, Feishu, Fengmen [Damp-heat syndrome] Hegu, Quchi, Zusanli, Sanyinjiao and Yinlingquan, once every other day, 10 treatments/course, 3 courses | Conventional treatment, 4weeks | 1) Skin lesions score scale 2) Systemic symptom based on TCM-related symptoms of acne: complexion, emotion, urination, stool, sleep, appetite, menstruation, etc. | NR | NR |
| L00-L99 Diseases of the skin and subcutaneous tissue | Liu | 2019 | China | Oral lichen planus (OLP) patients with anxiety or depression | 30/30; (13/17; 12/18) | 30/30; (13/17; 12/18) | 48.30±7.90;49.06±7.03/1.64±0.63;1.62±0.57(yr) | Hydroxychloroquine (HCQ)100mg/times,2times/day,4weeks+modified Xiaoyao pill,6g/time,2times/day,4weeks | Hydroxychloroquine 100mg/times, 2 times/day, 4 weeks | 1) Semi quantitative reticular erosive 2) Ulcerative lesion (REU) 3) Visual analogue scale（VAS） | NR | Modified Xiaoyao pill was effective and safe in the treatment of OLP patients with anxiety or depression, especially for EOLP |
| M00-M99 Diseases of the musculoskeletal system and connective tissue | Aydin | 2019 | Turkey | Dizziness caused by cervical myofascial pain syndrome | 31/30; NR | 30/25; NR | 36.9±8.5;40.1±7.9/28.0±3.7;42.0±7.7 | Dry needling therapy(trapezius and sternocleidomastoid muscles, 4 times(Tues-Fri/w, 4w) + exercise | Exercise | 1) Neck Pain Severity (Visual Analog Score) 2) Algometric Measurement 3) Number of Dizziness Attacks per Week 4) Severity of Dizziness 5) Fall Index | NR | Both dry needling1exercise therapy and exercise therapy alone were effective in treating dizziness caused by cervical myofascial pain syndrome. However, dry needling1exercise treatment was superior to exercise treatment alone. |
| M00-M99 Diseases of the musculoskeletal system and connective tissue | Bostrom | 2019 | Norway | Lateral epicondylitis | 13/12/11; (7/6; 9/3; 5/6) | 13/12/11 (7/6; 9/3; 5/6) | 51±4; 49±2; 47±3/ nr | 1) Eccentric exercise+ acupuncture(LI11, LI10, LU5, LI4, TE5, GB34, ST36) 2) Eccentric exercise+ manual, 12-weeks | Eccentric exercise, 12weeks | 1) Patient retention 2) Adherence rates 3) Patient-reported Pain (NRS) 4) Level of disability (Quick-DASH) 5) Participant’s satisfaction with treatment and global perceived effect | None | Based on differences in pain relief between groups, patient retention, and adherence rates, an RCT seems to be feasible to assess treatment effectiveness more precisely. In a future definitive trial, greater dropout may be reduced by maintaining contact with the participants in the exercise alone group throughout the intervention, and objective assessments might be considered. |
| M00-M99 Diseases of the musculoskeletal system and connective tissue | Chi | 2019 | China | Postoperative Recovery | 26/26; (20/6; 21/5) | 26/26; (20/6; 21/5) | 69.0 ± 6.0; 68.7 ± 2.5 / nr | Transcutaneous electrical acupoint stimulation (TEAS, ST36, SP6, PC6, LI11, 30 min prior to the epidural anesthesia, POD 1,2) | Sham stimulation | 1) Quality of Recovery-40 questionnaire (QoR-40) 2) Stress and inflammatory responses: Cortisol (COR), Adrenocorticotropic Hormone (ACTH), C-reactive protein (CRP), Neutrophil)lymphocyte ratio (N)L) 3) Visual analogue scale (VAS) | NR | perioperative TEAS administration is able to facilitate the development of postoperative recovery of elderly patients, especially at the early stage after surgery. The reported results are likely to be mediated by the reduction of surgical inflammation and perioperative stress response. |
| M00-M99 Diseases of the musculoskeletal system and connective tissue | Cui | 2020 | China | Henoch-Schonlein purpura | 60/60; (32/28; 30/30) | 60/60; (32/28; 30/30) | 6.70±2.90;6.80±2.80/3.53±0.91;3.56±0.92 | Yupingfeng San (5 g/time, tid) + conventional treatment, 14 days | Conventional medicine | 1) Disappearance time of purpura 2) Time of relief in abdominal Pain 3) Time of relief in arthralgia 4) Recurrence rate 5) Oxidative stress responses 6) Immune states: (Ig) E, IgA, and IgG. 7) The levels of interleukin: (IL)-10, IL-21, and IL-33 | NR | For children with HSP, conventional treatment combined with YPFS can significantly relieve the clinical symptoms, reduce the oxidative stress and inflammatory responses, and improve the immune system function, so it is worthy of clinical application. |
| M00-M99 Diseases of the musculoskeletal system and connective tissue | Dong(2) | 2019 | China | Neck type of cervical spondylopathy | 75/75; (45/30; 47/28) | 75/75; (45/30; 47/28) | 47.8±12.6; 50.2±12.8 / 4.4±1.5; 4.6±2.0 | Acupoint injections of Shenfu(Jiaji acupoint, Tianzong, Jianjing, Shousan Li, Hegu, Quchi, Ashi acupoint, injected with 0.8-1 mL of Shenfu injection, once a day for 1 month)+ mecobalamin tablets(0.5 mg each time, tid, 1 month) | Methylcobalamin tablets and point injections of normal saline | 1) Efficacy 2) Visual analogue scale scores (VAS) 3) Neck Pain questionnaires (NPQ) 4) Japanese Orthopedic Association (JOA) scoresspinal 5) Functional improvement 6) CK level 7) LDH levels | None | Acupoint injections of Shenfu combined with mecobalamin tablets can effectively relieve cervical pain symptoms of the neck type of cervical spondylopathy, reduce levels of CK and LDH, and promote the recovery of cervical muscle injuries and spinal cord nerve function. Therefore, its efficacy is significantly better than that of mecobalamin tablets alone. |
| M00-M99 Diseases of the musculoskeletal system and connective tissue | Kim | 2018 | Korea | Chronic nonspecific neck pain | 53/53; NR | 51/53; (11/40; 13/40) | 42.08± 13.10; 43.81± 10.96/ 71.76 ± 73.59; 69.17 ± 62.86 | Thread-embedding acupuncture (TEA) using polydioxanone + usual care, once a week, 4 weeks | Usual care | 1) Neck Pain and Disability Scale (NPDS) score 2) Clinically important difference (CID) 3) Pressure Pain threshold (PPT) 4) Hospital Anxiety and Depression Scale (HADS) 5) EuroQol-5 Dimension (EQ-5D) 6) Patient global impression of change (PGIC). | Temporary stiffness was observed after TEA treatment, but no serious adverse events occurred. | The results suggest that polydioxanone TEA is a safe and clinically beneficial adjunctive treatment for patients with CNP. |
| M00-M99 Diseases of the musculoskeletal system and connective tissue | Kizhakkeveettil | 2019 | USA | Low back pain | 100; NR | 23/28/29; (16/7; 12/16; 12/17) | male 40.7± 12.5; 42.5± 17.1; 405± 17.5/ NR female 37.9± 18.6; 44.9± 14.6; 45.1± 14.8/ NR | 1) Integrative acupuncture 2) Spinal manipulation therapy (SMT) 3) Interative acupuncture +SMT | 1) Iimprovements in LBP-related Pain and disability: Roland-Morris Disability Questionnaire and numeric Pain scales 2) Decreased missed days of work, days per week with LBP, percentage of time with LBP, Pain pills taken during the past week because of LBP | NR | An association was found between self-reported gender and response to LBP treatment. Womendemonstrated a greater reduction in pain and disability with acupuncture and men with SMT. Future clinical trials should consider sex as a potential determinant of treatment outcomes for LBP. | |
| M00-M99 Diseases of the musculoskeletal system and connective tissue | Liu(3) | 2020 | China | Cervical spondylotic radiculopathy | 42/42/42; (23/19; 20/22; 24/18) | 42/42/42; (23/19; 20/22; 24/18) | 49.28±8.30;49.75±8.64;48.96±8.07/ 5.72±2.83;5.90±2.38;5.36±2.95 | 1) Warm acupuncture(neck clip ridge, Dazhui, Tianzong, Quyuan, Jianyu, Binao, Quchi and Shousanli) 2) Stereo-dynamic interferential electrotherapy(on both sides of the cervical vertebra, basic frequency 5000 Hz, difference frequency 0-200 Hz, dynamic rhythm 10±2 s) 3) combined treatment(warm acupuncture group + stereo-dynamic interferential electrotherapy group), once a day, 5 days/course, 2 days washout period, 2 courses | 1) Clinical efficacy 2) Visual analogue score (VAS) 3) Cervical dysfunction index NDI (Neck Disability Index) 4) Hemodynamic indexes of vertebral artery - diameter, velocity and flow 5) Serum contents of endothelin (ET) and nitric oxide (NO) | NR | Warm acupuncture combined with stereo-dynamic interferential electrotherapy has a better therapeutic effect on CSR and can improve hemodynamics. | |
| M00-M99 Diseases of the musculoskeletal system and connective tissue | Luo | 2019 | China | Knee osteoarthritis | 30/30; (12/18; 13/17) | 30/30; (12/18; 13/17) | 50±8;51±9 /50.2±26.3;52.2±25.3(months) | Acupuncture(Ashi points, ST 36, GB 34, SP 9, EX-LE 4, ST 35, 30 min once every other day, 2 weeks) + medication therapy | Medication therapy(external application of Diclofenac Diethylamine Emuigel around the affected joint, 3 times a day, 2weeks) | 1) Visal analog scale(VAS) 2) Western Ontario McMaster Universities Osteoarthritis index(WOMAC) scale 3) Diagnasis of Syndromes of Traditional Chinese Medicine | NR | Acupuncture combined with medication has a better therapeutic effect in the treatment of KOA in the early stage than that of the simple medication. |
| M00-M99 Diseases of the musculoskeletal system and connective tissue | Nicolian | 2019 | Canada | Pelvic and low back pain pregnancy | 96/103; NR | 96/103; NR | 31 ± 5.2; 30.7 ± 4.6 | Acupuncture(40V, Weizhong, Ashi points, 5 acupuncture sessions) + standard care | Standard care | 1) Efficacy: proportion of days with self-assessed Pain by numerical rating scale (NRS)≤ 4)10. 2) Cost effectiveness (societal viewpoint, time horizon: pregnancy) | Acupuncture-specific side effects occurred in 32 (33%) patients and included bruising (n = 24, 25%), fatigue (n = 9, 8%), dizziness (n = 1, 1%) and headache n = 1 (1%). | Acupuncture was a dominant strategy when accounting for employer costs. A 100% probability of cost-effectiveness was obtained for a willingness to pay of €100 per days with pain NRS ≤ 4. |
| M00-M99 Diseases of the musculoskeletal system and connective tissue | Tang | 2020 | China | Rheumatoid arthritis | 120/120; NR | 106/106; (23/83; 11/95) | 48.78±11.43;47.51±10.81/ NR | 1.1) Gulong capsules + methotrexate(40) 1.2) Gulong capsules + leflunomide(80) | 2.1) Gulong capsules simulation agent + methotrexate(40), 12 weeks 2.2) Gulong capsules simulation agent + leflunomide(80), 12 weeks | 1)T he proportion of patients with improvement degree ≥20% of the American College of Rheumatology (ACR) scoring criteria (ACR20) 2) Traditional Chinese medicine (TCM) syndrome efficacy 3) Disease activity score in 28 joints (DAS28) 4) Physical signs score 5) Safety | NR | Gulong capsules combined with DMARDs has better curative effect than DMARDs alone for the treatment of RA,and it is an effective treatment option for RA that can significantly improve the patient’s clinical signs and symptoms |
| M00-M99 Diseases of the musculoskeletal system and connective tissue | Tang(2) | 2019 | China | Rheumatoid arthritis | 85/85; NR | 85/85; NR | 40.3±8.5;41.8±7.2/ 4.3±1.2;5.2±1.3(yr) | Zushima tablet(3 tablets/time,3times/day,6months) + western medicine | Western medicine(Naproxen sustained-release tablets, 75 mg, qd + prednisone, 10mg, qd, 2 months + methotrexate 10mg, once a week + sulfasalazine 0.25mg, bid/w) | 1) Joint swelling 2) Joint tenderness 3) Duration of morning stiffness | NR | Application of combined therapy of Zushima tablet and western medicine in treatment of rheumatoid arthritis could lead to favorable effects and improvement of the patients’ clinical symptoms. |
| M00-M99 Diseases of the musculoskeletal system and connective tissue | Wan | 2019 | China | Primary osteoporosis | 36/36; (14/22; 16/20) | 36/36; (14/22; 16/20) | 63.97±3.70;63.36±3.07/ NR | Dihuang Decoction(地黄饮子,DHD)one dose each time,one time in the morning and one time in the evening,twice a week． | Alendronate 70 mg orally once a week | 1) Bone mineral density (BMD) 2) Serum collagen typeⅠ C-terminal peptide (beta-CTX), serum osteoclast (SOST) | NR | In this study,traditional Chinese medicine DHD is used to treat osteoporosis． It is found that DHD and alendronate have a good effect． The DHD can be used as a choice of Chinese medicine in the treatment of primary osteoporosis． |
| M00-M99 Diseases of the musculoskeletal system and connective tissue | Wang | 2019 | China | Chronic Knee Pain | 36/36; (15/21; 13/23) | 36/36; (15/21; 13/23) | 64.8±9.3;65.1±8.9/ NR | Percutaneous electrical nerve stimulation(PENS), 3 times/week, 8 weeks | Sham percutaneous electrical nerve stimulation, 3 times /week, 8 weeks | 1) Numeric rating scale (NRS) 2) Western Ontario and McMaster Universities arthritis index (WOMAC) 3) Short-form 36-item health survey (SF-36) 4) Mental component scale (MCS) | NR | The findings suggest that treatment with the real PENS with etoricoxib is effective for treatment of CKP |
| M00-M99 Diseases of the musculoskeletal system and connective tissue | Wang(3) | 2019 | China | Acute facial neuritis | 30/30/30/30; NR | 30/30/30/30; NR | 34±7;35±8;35±7;34±9/ 2.1±0.8;2.1±0.8;2.3±0.9;2.0±0.8(d) | 1) Acupuncture performed within 3 days | 2) Oral medicine + Acupuncture performed within 4 days 3) Oral medicine + Acupuncture performed within 6 days 4) Oral medicine + Acupuncture performed within 8 days | 1) Symptom scores(Portmann scores) 2) The time of improvement 3) Clinical efficacy | NR | Early intervention of acupuncture with acute facial neuritis can appropriately slow the progression of facial nerve injury, improve the therapeutic effect, and shorten the clinical recovery time. |
| M00-M99 Diseases of the musculoskeletal system and connective tissue | Wang(4) | 2020 | China | Rheumatoid arthritis | 35/35; (3/32; 4/31) | 32/27; NR | 42.74±10.35;44.40±11.36/26.12±31.46;35.19±33.45 | Biqi capsule(1.2 g, bid, 24w) + methotrexate (MTX) | Leflunomide(20 mg once daily) + MTX | 1) Proportion of patients who achieved a 20% improvement in ACR criteria (ACR20) at 24 weeks and at least a 20% improvement in ３ or more of PhGADA or PaGADA, Pain on a visual analogue scale, HAQ、ESR, CRP 2) ACR50 and ACR70, EULAR response 3) Adverse events(AEs), serious AEs, and laboratory abnormalities. | Biqi with significantly fewer adverse effects reported (11.4%) compared to LEF group (40%, P < 0.05 | Our study suggests that Biqi capsule can be a promising alternative option in combination with MTX for RA treatment, and demonstrates the capability of using metabolomics to interrogate mechanism of action for traditional Chinese medicine. |
| M00-M99 Diseases of the musculoskeletal system and connective tissue | Wang(5) | 2019 | China | Rheumatoid arthritis | 60/60; NR | NR; NR | NR | Jia Wei Niu Bang Zi granule (NBZG, 4 g, bid, 12w) + MTX(5mg/w, 12w) | Placebo(4 g, bid) + MTX(5mg/w), 12 weeks | 1) American College of Rheumatology (ACR) 50 2) DAS28, rate of ACR20)70 3) HAQ-DI 4) 36-item Short-Form Health Survey Questionnaire (SF-36) 5) Patient Assessment of Arthritis Pain 6) Patient Global Assessment of Arthritis 7) Athens insomnia sleep scale | NR | NR |
| M00-M99 Diseases of the musculoskeletal system and connective tissue | Wei | 2019 | China | Hemiplegic shoulder pain | 20/20; NR | 20/20; NR | 63.85 ± 11.07; 65.55 ± 13.30 / 2.50 ± 1.54; 2.25 ± 1.68 | Acupuncture(LI15, SI9, SJ14, SI11, EX-UE, LI14, LI11, LI10, SJ5, LI4) + neuromuscular joint facilitation (NJF) | Acupuncture alone(LI15, SI9, SJ14, SI11, EX-UE, LI14, LI11, LI10, SJ5, LI4) | 1) Visual analogue scale (VAS) 2) Fugl-Meyer assessment(FMA) 3) Barthel index (BI) 4) Passive range of motion (PROM) | NR | Both acupuncture alone and acupuncture combined with NJF in the treatment of HSP are effective, and can improve the clinical symptoms of patients. Acupuncture combined with NJF can improve the upper limb motor function, relieve pain, and increase joint mobility in patients with HSP. The combination therapy is better than acupuncture alone. However, there is no significant difference in improving the score of patients’ self-care ability. |
| M00-M99 Diseases of the musculoskeletal system and connective tissue | Wu | 2020 | China | Auxiliary analgesic effect | 32/32; (19/13; 20/12) | 32/32; (19/13; 20/12) | 45±12;48±14/ 2.3±0.9;2.1±0.8(yr) | Wrist-ankle acupuncture before routine local infiltration anesthesia | Routine local infiltration, anesthesia | 1) The mean arterial pressure(MAP), heart rate (HR), blood oxygen saturation (SpO2) and Pain visual analogue scale (VAS) 2) The intention of reoperation 3) The expectation and treatment credibility scale (ETCS) | NR | The wrist-ankle acupuncture has positive auxiliary analgesic effect on lumbago during transforaminal endoscope surgery, and strengthens the patients' confidence on the operation effect. |
| M00-M99 Diseases of the musculoskeletal system and connective tissue | Zeng | 2019 | China | Rheumatoid arthritis | 20/20/20; (5/15; 5/15; 6/14) | 20/20/20; (5/15; 5/15; 6/14) | 49;55;46/5.3±1.2;6.0±1.8;5.7±1.4 | 1) Simple needling + MTX + LEF 2) Electroacupuncture (EA) + MTX + LEF, every other day , 10 times, 8 weeks. | Methotrexate + leflunomide (MTX + LEF) | 1) Erythrocyte sedimentation rate (ESR) 2) Level of C-reactive protein (CRP) 3) Tartrate-resistant acid phosphatase- 5b (TRACP-5b) 4) Bone-specific alkaline phosphatase (B-ALP) 5) Interleukin-17 (IL-17) 6) Carboxyterminal propeptide of type Ⅰ procollagen (PICP) 7) N-terminal-midfragment of osteocalcin (N-MID) 8) The β form of the C-terminal telopeptide of type I collagen (β-CTx) 9) Joint hyperplasia: SJC: swollen joint count; TJC: tender joint count; VAS: visual analog scale 10) DAS28 gradingcl | NR | EA could effectively reduce the suffering and improve the quality of life of RA patients. It is a promising adjuvant therapy for enhancing the effectiveness of clinical therapeutics. |
| M00-M99 Diseases of the musculoskeletal system and connective tissue | Zhang(2) | 2019 | China | Lumbar disc herniation | 236/259; (106/153; 105/131) | 236/259 (106/153;105/131) | 56.49±13.62;54.56±13.75/ NR | Shenzhuo Decoction(twice a day with 1 dosage,2weeks) + regular massage manipulation, acupotomy and lumbar traction | Regular massage manipulation, acupotomy and lumbar traction | 1) Clinical effects | NR | Shenzhuo Decoction in the treatment of lumbar disc herniation has good curative effect. It has the advantages of quick curative effect and short courses of treatment with the regular massage manipulation, acupotomy and lumbar traction, which can be promoted in clinical practice as a conservative treatment for lumbar disc herniation. |
| M00-M99 Diseases of the musculoskeletal system and connective tissue | Zhang(8) | 2019 | China | Knee osteoarthritis | 30/30/30; (15/15; 16/14; 14/16) | 30/30/30; (15/15; 16/14; 14/16) | 55.9±5.8;54.9±6.2;54.7±6.2/ 6.6±2.0;6.5±1.8;6.2±1.8 | 1) Acupuncture (AP, EX-LE 5, ST 35, ST 36), Yinlingquan (SP 9, LV 8, ST 34, SP 10, Ashi point, once a day) + usual care (UC) 2) Electroacupuncture (EA, 2/100 Hz frequency and 0.2 ms pulse width for 30 min, EX-LE 5 was connected to ST 35, and SP 9 connected to Ashi point with a pair of electrodes) + UC | Usual care (UC) | 1) Pain visual analogue scale)score(VAS) 2) Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC Index) 3) Assessment of Quality of Life instrument version of the 36-item Short Form Health Survey (QoL-SF36) | None | AP or EA combined with usual care is more effective than usual care alone for the treatment of KOA, the intervention of electric current in the process of acupuncture may improve more domains of AQoL-SF36 in KOA patients. |
| M00-M99 Diseases of the musculoskeletal system and connective tissue | Zheng | 2018 | Australia | Chronic Musculoskeletal Pain | [EA/SEA/PMN] 48/29/31; (20/28; 11/18; 16/15) | [Short-term effects] 36/27/27; NR [Long-term effects] 25/20/26; NR | 55.9±11.3;54.8±13.7;58.4±12.8/ 10.8±9.4;13.3±9.6;16.3±12.5 | 1) Electroacupuncture(unilateral LI10, LI4, ST36, ST40, eight supplementary points chosen according to the adverse effects of OM) + pain and medication management education 2) Sham electroacupuncture + pain and medication management education, 12w | Pain and medication management education | 1) Opioid medications(OM) dosage 2) Number of participants who achieved 50% OM reduction at the end of the treatment and follow-up periods 3) Incidence and severity of OM-related common AEs 4) Consumption of non-OMs for Pain. 5) Medication Quantification Scale, version III to quantify non-OMs. 6) Pain: visual analogue scale 7) Beck Depression Inventory 8) Quality of life: the 36-item Short-Form Health Survey version 2 (SF-36v2) 9) Disability: the Roland Morris Disabilities Questionnaire 10) The Perception of EA Treatment Questionnaire | Adverse events to electroacupuncture were minor. | It is safe to reduce opioid medication use in patients with chronic pain. Due to the small sample size, we could not confirm if electroacupuncture offers extra benefit in addition to education. This nondrug therapy could be a promising adjunct to facilitate opioid tapering in patients who are willing to reduce opioids. |
| M00-M99 Diseases of the musculoskeletal system and connective tissue | Zhu(3) | 2019 | China | Ankylosing spondylitis | 29/28/30; (23/6; 21/7; 21/9) | 29/28/30; (23/6; 21/7; 21/9) | 31.68±9.32;33.50±10.82;35.42±7.46/ 10.12±4.07;12.68±6.12 | 1) Bushen Qiangdu Recipe (BQR) + sulfasalazine(2g/d) 2) Sulfasalazine(2 g/d), 3 months | normal (healthy volunteer) | 1) Assessment in Ankylosing Spondylitis Response Criteria 20 (ASAS 20), Bath Ankylosing Spondylitis Disease Activity Index (BASDAI), Bath Ankylosing Spondylitis Functional Index (BASFI), and Bath Ankylosing Spondylitis Metrology Index (BASMI) 2) Laboratory examination 3) CRP and ESR 4) Collagen, FN, IL-6, and MMP-3 | 2 cases had a digestive reaction and 1 case developed a skin rash | Combined BQR and sulfasalazine treatment reduced cytokine levels and improved the symptoms of AS, and it showed a better effect and safety than sulfasalazine alone. |
| N00-N99 Diseases of the genitourinary system | Feng(2) | 2019 | China | Pelvic inflammatory disease | 60/60; NR | 57/55; NR | 36.56±6.59;40.39±7.44/ NR | Fuyanshu Capsules for 56 d,and levofloxacin hydrochloride tablets and metronidazole tablets for 14 d | Fuyanshu Capsules as its analogue for 56 d,and levofloxacin hydrochloride tablets and metronidazole tablets for 14 d | 1) Curative rate - McCormack score and traditional Chinese medicine (TCM) syndrome score 2) Effective rate 3) Inefficiency 4) Serum IL-10 and IL-1β levels | NR | The results showed that Fuyanshu Capsules combined with levofloxacin and metronidazole could alleviate the clinical symptoms and signs of chronic pelvic inflammation of damp－heat stagnation type,reduce the recurrence rate of pelvic inflammation,relieve pelvic pain,and alleviate the inflammation status of patients by regulating the expression of IL-10 and IL-1β in peripheral serum． |
| N00-N99 Diseases of the genitourinary system | Fujiwara | 2020 | Japan | Transurethral Resection of the Prostate | 27/27; NR | 23/27; NR | 71;73/NR | Goreisan(2.5 ,on the night before surgery and on the morning of surgery) | 1) Occurrence of TUR syndrome 2) Serum sodium level | None | These findings indicate that preoperative Goreisan administration can help maintain serum sodium levels in patients undergoing TUR of the prostate. | |
| N00-N99 Diseases of the genitourinary system | Hullender Rubin | 2019 | USA | Provoked localized vulvodynia | 10/9; NR | 7/7; NR | 29.7 ± 7.6; 28.6 ± 7.7 / 73.0 ± 92.5; 74.8 ± 96.0 | Traditional acupuncture (3 core points, 2 additional points based on TCM diagnosis) + lidocaine 5% cream 4 times daily, 18 sessoin(twice weekly for 6 weeks, followed by once weekly for 6 weeks), 12weeks | non traditional acupuncture (NTA)+lidocaine 5% cream 4 times daily A standardized intervention of 4 needles on nonspecific points. 18 sessoin(twiceweekly for 6 weeks, followed by onceweekly for 6 weeks), 12weeks | 1) Tampon test scores (TT) 2) Cotton swab test (CST) 3) Patient-Reported Outcomes Measurement Information System (PROMIS) 4) Response rate (percent change) in TT scores | Study drug induced AE(7), Acupuntre induced AE(5); No SAE. | In this early-phase research, acupuncture augmentation of lidocaine was acceptable. The study procedures, with modifications, may be feasible for future investigation. Both acupuncture techniques showed a favorable effect; however, the contribution to pain relief is undetermined. |
| N00-N99 Diseases of the genitourinary system | Jin(2) | 2020 | China | Histiocytic necrotizing lymphadenitis | 36/36; (9/27; 7/29) | 36/36; (9/27; 7/29) | 28±7;30±9/ 16.75±15.32;14.52±17.86(d) | Acupoint application(TE 5, GB 20, ashi point, once a day, 14days) and ultrasonic drug penetration therapy + oral administration of prednisone tablets | Prednisone tablets(first 5 days: 10 mg, three times a day; since then, reduced by 5 mg every 7 days, 40days) | 1) Changes of target lymph node swelling 2) Visual analogue score (VAS) 3) Axillary temperature 4) Total score of symptoms and signs 5) Changes of white blood cell (WBC), erythrocyte sedimentation rate (ESR), C-reactive protein (CRP) and lactic dehydrogenase (LDH) | NR | The medicinal penetration on acupoint as adjunctive treatment could effectively relieve the discomfort symptoms of HNL patients with syndrome of heat and toxin, improve the clinical cured rate, and provide the research direction for shortening the course of medication. |
| N00-N99 Diseases of the genitourinary system | Li(5) | 2019 | China | Menstrualmigraine | 30/30/30; NR | 30/30/30; NR | 35.5 ± 4.1;36.2±2.9;35.7±2.6/ 12.3±1.4;11.9±1.6;12.5±1.8(months) | 1) Acupuncture treatment(taichong, yongquan, 30 min, once a day, 10 days/course, 3 courses) | 2) Drug therapy(fluoroguirizine hydrochloride capsules,course1:10mg/day,1week.course2: 10mg/day, 5days/week,1 week, course 3:10mg, 5 days/week, 2 week 3) Acupuncture+ medication | 1) Total headache score 2) Migraine specific quality of life questionnaire(MSQ) 3) Plasma calcitonin gene-associated peptide(CGRP) 4) 5-hydroxytryptamine (5-HT) | NR | The clinical effect of acupuncture taichong and yongquan points on the treatment of menstrual Migraine is significant. It can significantly improve the patients headache symptoms and lift their quality of life. |
| N00-N99 Diseases of the genitourinary system | Qi | 2019 | China | Breast pain and vaginal bleeding | 60/60; NR | 58/58; NR | 59.77±3.99;58.22±3.32/ NR | Kuntai capsules (4 capsules per time, 3 times a day)+ diclofenac sodium enteric-coated tablets(25mg, 3 times a day) | Diclofenac sodium enteric-coated tablets(25mg, tid) | 1) Serum estradiol 2) Follicle stimulating hormone 3) Luteinizing hormone 4) Modified Kupperman score | NR | The incidence of vaginal bleeding, breast distending pain in group was obviously higher in control group than Kuntai group. Thus, Kuntai capsule improved the ovarian function of patients, raised the level of estrogen in vivo and alleviates the clinical manifestations of Breast pain. |
| N00-N99 Diseases of the genitourinary system | Shuai | 2019 | China | Recurrent implantation failure undergoing in vitro fertilisation | 61/61; NR | 57/58; NR | 31.23±3.78; 31.58±3.07/ 5.09±2.78; 5.71±3.59 | Transcutaneous electrical acupuncture stimulation (TEAS, SP6, CV3, CV4, Zigong, 30 min (9–25 mA, 2 Hz) from day 5 of the ovarian stimulation cycle once every other day until the day of embryo transfer) | Mock TEAS (MTEAS) | 1) Pregnancy outcomes 2) Ovarian stimulation and embryo transfer characteristics | NR | TEAS significantly improves the clinical outcomes of subsequent IVF cycles among women who have experienced RIF. |
| N00-N99 Diseases of the genitourinary system | Wang(2) | 2019 | China | Benign prostatic hyperplasia | 55/55; NR | 55/55; NR | 64.15±3.52; 64.03±3.20/4.29±0.71; 4.40±0.85(yr) | Jisheng Shenqi Decoction (JSSD) ,twice a day,30days + transurethral holmium laser enucleation of the prostate (HoLEP) | Transurethral holmium laser enucleation of the prostate (HoLEP) | 1) IPSS 2) Quality of life (QOL) score 3) Prostate volume 4) Postvoid residual urine volume (PVＲ) 5) Maximum urinary flow rate (Qmax) 6) Average urinary flow rate (Qavg) 7) Levels of serum T,E2 and T)E2 | NR | HoLEP + JSSD can significantly alleviate the lower urinary tract symptoms as well as improve the QOL and bladder and urinary tract functions of BPH patients |
| N00-N99 Diseases of the genitourinary system | Wei | 2020 | China | Gynecological laparoscopic surgery | 42/41; NR | 41/39; NR | 44.7±10.8;47.3±11.0/140.1±39.4;149.3±49.3 | Transcutaneous electrical acupoint stimulation (BL13, LI4, LU5) | No stimulation | 1) Hemodynamic index and blood gas analysis - mean arterial pressure, heart rate and oxygen saturation, Arterial blood gas analysis 2) Tumor necrosis factor (TNF)-α and interleukin (IL)-1β 3) Post-operative pulmonary complications | NR | It was therefore indicated that TEAS protect against lung injury as a complication of gynecological laparoscopic surgery. |
| N00-N99 Diseases of the genitourinary system | Zhang | 2020 | China | Refractory plasma cell mastitis | 46/46; NR | 46/46; NR | 47.4±3.1; 48.3±3.3/15.52±2.14;15.49±2.11 | Surgery(cefoxitin sodium and cefuroxime injections for 7 consecutive days before surgery until their condition stabilized ) + Shengyang Yiwei decoction and Yanghe decoction, bid, 4 weeks | Surgery(cefoxitin sodium and cefuroxime injections for 7 consecutive days before surgery until their condition stabilized) | 1) The clinical efficacy 2) Traditional Chinese medicine (TCM) symptom score 3) Treatment duration 4) Recurrence rate 5) Quality of life | None | The combination of Shengyang Yiwei decoction and Yanghe decoction and surgery has a significant effect in the treatment of refractory plasma cell mastitis, and significantly reduces the clinical symp-toms, shortens the treatment duration and lowers the recurrence rate. |
| N00-N99 Diseases of the genitourinary system | Zhang(3) | 2019 | China | Abnormal uterine bleeding-ovulatory dysfunction | 30/30; NR | 27/28; NR | 34±7;37±7/ 5.4±2.0;5.3±1.9(months) | Acupoints therapy, [After menstrual period] SP 10, SP 6, KI 3, CV 4, CV 6, ST 36, LR 13 [Ovulaton periods] LR 3, LI 4, GV 3, BL 17, BL18, SP 6, BL 20 [Before menstrual period] GV 20, BL 23, GV 3, BL 17, SP 6, ST 36, SP 4 | Medication artificial menstrual cycle method(Femoston (estradiol tablets/estradiol dydrogesterone tablets) was taken orally. The white tablets were estradiol (1 mg), while the gray tablets were estradiol (1 mg) and dydrogesterone (10 mg). The Femoston was taken once a day, white tablets for the first 14 days, then gray tablets for the last 14 days) | 1) Clinical symptom score 2) Clinical efficacy (total effective rate, the marked effective rate of main symptoms (including menstrual cycle, menstrual period, menstrual volume) and basal body temperature(BBT) | NR | Acupuncture artificial menstrual cycle method has superior efficacy for AUB-O dysfunction (spleen deficiency syndrome), which has similar efficacy with medication artificial menstrual cycle method. Moreover, acupuncture has advantages in regulating menstrual cycle and improving ovulation, and has a longer curative effect. |
| N00-N99 Diseases of the genitourinary system | Zhang(9) | 2019 | China | Chronic prostatitis | 105/105; NR | 105/105; NR | 39.29±6.72;38.38±5.86/1.44±0.63;1.45±0.81 | Yishen decoction + antibacterial drugs(300 mL, tid, 4 weeks) | Levofloxacin hydrochloride capsules, 0.2 g, bid + terazosin hydrochloride tablets 1.0 mg, qd | 1) National Institutes of Health chronic prostatitis symptom index (NIH-CPSI) 2) Expressed prostatic secretions (EPS) 3) Meares localization 4) Inflammatory factors in serology 5) Curative effect evaluation 6) Satisfaction rate evaluation | NR | Yishen decoction can effectively treat chronic prostatitis by relieving pain and discomfort and improving the CP patients’ quality of life. |
| N00-N99 Diseases of the genitourinary system | Zhao | 2020 | China | After Surgery for Endometriosis-Associated Infertility | 102/102; NR | 101/101; NR | 29.2±3.2; 29.7±3.1/24.8±15.8; 26.5±20.6 | Chinese medicine(Before ovulation: Huoxue Xiaoyi Granule, after ovulation: Bushen Zhuyun Granule, 1–5 days after surgery, for 6 menstrual cycles) | Placebo | 1) Clinical pregnancy rate and pregnancy outcome 2) Follicular development and endometrial receptivity | Adverse events: the incidence of adverse events between the two groups was not significantly different (P>0.05) | Strategies for activating blood circulation-regulating Gan (Liver)-tonifying Shen (Kidney) sequential therapy can ef fect ively improve the cl inical pregnancy rate and live birth rate of endometriosis-associated infertility with qi stagnation and blood stasis after laparoscopy, improve follicular development, promote ovulation, improve endometrial receptivity, while being a safe treatment option. |
| N00-N99 Diseases of the genitourinary system | Zhu(2) | 2019 | China | Chronic nonbacterial prostatitis | 30/30; NR | 30/30; NR | 42.6±11.8;43.0±11.9/ 8.0±5.5;7.9±5.4(yr) | Acupuncture(Sanhuang points, once a day, 8weeks) + medication(Tamsulosin, 0. 2 mg/d) | Tamsulosin (0. 2 mg/d), 8 weeks | 1) Chronic Prostatitis Symptom Index (NIH-CPSI) scores 2) Leukocyte count in the prostatic fluid | NR | Acupuncture at Sanhuangpoints is effective in improving symptoms of CNP patients of kidney-yang deficiency type , and the therapeutic effect of acupuncture plus medication is superior to that of medication alone. |
| O00-O99 Pregnancy, childbirth and the puerperium | Dehghani | 2020 | Iran | In vitro fertilization | 62/62/62; NR | 62/62/62; NR | 32.1±5.9;32.9±4.8;31.5±5.4/5.7±3.4;5.1±3.1;5.4±4.0 | 1) Acupuncture(HT7, PC6, RN6, DU20, SP6, RN4, 25 min before embryo transfer (ET) (ACU1) 2) acupuncture 25 min before and after ET (ACU2) | ET without acupuncture | 1) Pregnancy rates - biochemical, clinical, and ongoing | NR | Acupuncture 25 min before ET significantly increased the IVF outcomes in women undergoing IVF compared with no acupuncture. Repeating acupuncture 25 min after ET did not improve the IVF outcome. |
| O00-O99 Pregnancy, childbirth and the puerperium | Dong | 2019 | China | Poor ovarian response | 25/25/25/25; NR | 25/25/25/25; NR | 33.7±4.9/ 34.0±5.1/ 33.9±5.0/ 33.6±5.3; [不孕年限] 5.3±1.9y/5.6±1.6y/5.2±1.6y/5.1±1.7y | 1) Medication(Climen, 1T, qd, 21d, 3 cycles) 2) Acupuncture, menstruation 8-15d(follicular phase), once daily, 3 menstrual cycles 3) Acupuncture + medication(1+2) | No treatment | 1) Serum follicle-stimulating hormone luteinizing hormone, estradiol, and serum anti-mullerian hormone 2) The antral follicles count of the ovaries by using a color Doppler ultrasonic diagnosis apparatus. | NR | Acupuncture combined with medication im proves the level of endocrinal hormones and ovarian reservation function in POR women undergoing IVF-ET,benefiting the ovary environment of pregnancy. |
| O00-O99 Pregnancy, childbirth and the puerperium | El-Shamy | 2018 | Egypt | Gestational diabetes mellitus | 15/15; NR | 15/15; NR | 24.5 ± 2.1; 23.9 ± 3.5 /nr | Acupressure(ST36, BL23, BL13, 3 sessions/week, 12weeks)+ standard antenatal care | Standard antenatal care | 1) Gestational diabetes: requirement for insulin, insulin resistance, 75-g oral glucose tolerance test (OGTT), Fasting and 2-h glucose levels 2) Neonatal outcomes: birth weight, gestational age at delivery, Apgar scores, mode of delivery | NR | Acupressure may help to reduce gestational diabetes or insulin treatment for overweight female patients with GDM. |
| O00-O99 Pregnancy, childbirth and the puerperium | Fang | 2019 | China | Labor analgesia | 40/40/40; NR | 36/35/36; NR | 30.4±4.1/28.9±4.9/29.1±4.8; NR | 1) Acupoint injection(Ropivacaine, 0.2%, 1 mL/acupoint, bilateral LI4, SP6) 2) Epidural analgesia(labor analgesia, puerpera's uterine orifice opened about ≥3 cm (the first stage of labor) + puerpera controlled epidural analgesia (PCEA, Sufentainil ＋ 0.1% Ropivacaine hydrochloride, 5 µg/mL at L3-L4 interspace, till the birth of fetus)) | No labor analgesia | 1) Delivery situations (such as the duration of labor, and number of cases who used oxytocin, obstetric-forceps-aided delivery, cesarean delivery) 2) The serum prolactin concentration 3) The visual analogue scale (VAS) scores 4) The duration of labor 5) Ratio of use of oxytocin 6) Onset time of breastfeeding 7) Times of breastfeeding within 24 postpartum hours | NR | Injection of Ropivacaine at LI4 and SP6 is effective for labor analgesia and raising prolactin level, and favorable to breastfeeding in the early postpartum period. |
| O00-O99 Pregnancy, childbirth and the puerperium | Guven | 2020 | Turkey | In vitro fertilization | 38/38; NR | 36/36; NR | 30.3±3.4;31.5±4/NR | Acupuncture [1st session] bilateral H-7, LI-4, GV-20, ear shenmen, one week before ET [2nd session] Bilateral CV-3,4,6, GV-20, LIV-3, ST-30, SP-8, 30 min before ET [3rd session] LI-4, SP-6,9, ST-36, 30 min after ET | 1) Pregnancy success rate - Beta- HCG level, clinical pregnancy, ongoing pregnancy, live birth 2) Anxiety level - STAI- 1 state anxiety scale | There was observed no serious side effect after acupuncture treatment. | It was observed that three sessions of acupuncture before and after ET significantly increased the pregnancy rates in women with unexplained infertility. It was also found that acupuncture significantly reduced anxiety levels that occurred before ET. | |
| O00-O99 Pregnancy, childbirth and the puerperium | Kim | 2019 | USA | Postpartum pain | 37/33; NR | 37/33; NR | 37; 3/ nr | Battlefield Auricular Acupuncture (BFA) + standard analgesia | Standard analgesia | 1) Pain via the standard numerical Pain rating scale 2) Total morphine equivalents used 3) Satisfaction with Pain management 4) Time in hospital postpartum ward 5) Complications | NR | This exploratory comparison suggests that BFA may not provide additional benefit to standard analgesia for immediate postpartum pain; however, the trend toward faster reduction in pain indicates that a larger definitive study may be required |
| O00-O99 Pregnancy, childbirth and the puerperium | Li(2) | 2020 | China | Latent stage of labor on the epidural analgesia | 37/36/31; NR | 37/36/31; NR | 30.3±4.2;30.5±5.3;30.8±4.7/ NR | 1) Electroacupuncture(EA)(Han's acupoint nerve stimulation apparatus, LI4, SP6, till cervix opened up 3 cm) + epidural block + patient-controlled epidural analgesia 2) Sham-EA(same as the EA group, withsham stimulation) | Epidural block | 1) Visual an alogue scale (VAS) 2) Dosage of Sufentanil and Ropivacaine inpatient controlled analgesia pump 3) Concentration of beta-endorphin (beta-EP), theusetme ofoxytocn, bleedng amount and the state of newborn | NR | Electroacupuncture analgesia at the latent stage of labor effectively relieves labor pain of primipara, increases the concentration of beta-EP, enhances the effect of epidural block analgesia, reduces labor bleeding and has no side effect on newborn. The combination of electroacupuncture analgesia and the epidural anesthesia in the latent stage is applicable in the whole process of labor. |
| O00-O99 Pregnancy, childbirth and the puerperium | Li(6) | 2019 | China | Pain | 31/36/37; NR | 31/36/37; NR | 30.4±4.8/ 30.3±5.2/30.4±4.8; 278.0±7.7d/ 277.1±7.9d/278.5±7.3d | Electroacupuncture on acupoints(bilateral LI4, SP6, 2 Hz/100 Hz, 30 min/session,15min break, 2 sessions) + epidural block | 2) Sham electroacupuncture + epidural block(shallow acupuncture needle stimulation without cutaneous penetration of the needle tip,and without stimulation electric current output) 3) Epidural block Only(EB) | 1) Visual Analogue Scale | NR | EA plus epidural analgesia,given during the latency period of labor,can effectively alleviate pain,inhibit stress response and reduce the dosage of anesthetics in pri⁃ miparous parturients throughout the labor process. |
| O00-O99 Pregnancy, childbirth and the puerperium | Mahmoudikohani | 2019 | Iran | Labor | 40/40/40; NR | 36/38/35; NR | 23.58 ± 3.7; 23.63 ± 3.86; 23.14 ± 3.34 | 1) Acupressure (SP6, BL 60, and BL 32) 2) Sham acupressure | Routine care | 1) Childbirth satisfaction | NR | This study demonstrated that acupressure may be used as a method in order to attempt to provide a good birth experience and satisfaction of childbirth. |
| O00-O99 Pregnancy, childbirth and the puerperium | Smith | 2019 | Australia, New Zealand | In Vitro fertilization | 424/424; NR | 301/307; NR | 35.7 ± 4.3; 35.7 ± 4.2 / nr | Acupuncture [1st treatment] ST‐29, Ren‐4, Ren‐6, SP‐6, SP‐10, [1 hour prior to embryo transfer] ST‐29, SP‐8, SP‐10, LR‐3, Ren‐4,Shenmen HT‐7, PC‐6, YinTang, Zhigong [following embryo transfer] DU‐20, KD‐3, ST‐36, SP‐6, PC‐6, ShenMen | Sham acupuncture (Park sham needle) | 1) Livebirth 2) Quality of life and anxiety | NR | Acupuncture may reduce anxiety at embryo transfer. Quality of life did not differ between the groups. Women experience reduced emotional well‐being 3 months following the IVF cycle, highlighting ongoing unmet psycho‐social needs. |
| O00-O99 Pregnancy, childbirth and the puerperium | Topraghlou | 2019 | Iran | Labor | 54/54/54; NR | 54/54/54; NR | 24.0 ± 4.1; 23.4 ± 3.7; 22..9 ± 4.0/ nr | 1) Acupressure at the Hugo point 2) Hyoscine | Routine cares | 1) Duration of labor stages and 2) fetal-neonatal outcome | The side-effects of hyoscine (e.g., dizziness, vertigo, and blurred vision) were reported in the group who received hyoscine. | Overall, the implementation of acupressure at the Hugo point led to a greater reduction in the duration of labor stages compared to hyoscine infusion without imposing the side-effects on mother. |
| O00-O99 Pregnancy, childbirth and the puerperium | Türkmen | 2019 | Turkey | Labor | 33/34; NR | 30/30; NR | 23.83±4.05;25.03±3.72(yrs) | Acupressure(SP6, about 90 times (40–48 times in active stage and 35–45 times in transition stage)) | SP6 toutched slightly without applying pressure | 1) Duration of active stage and transition stage: Partograph Form 2) Pain severity: numeric rating scale (NRS) 3) Effectiveness of acupressure, satisfaction with the intervention, whether they would recommend the same intervention to other pregnant women. | NR | Application of acupressure on SP6 was found to have a positive effect on pregnant women’s labor experience and reducing the labor pain and shortening the duration of first stage of labor compared to touch on SP6. The women receiving acupressure had higher levels of satisfaction in acupressure application than women receiving only touch on SP6, which could be as a result of reduced pain in labor and/or shorter duration of labor. |
| O00-O99 Pregnancy, childbirth and the puerperium | Wu(3) | 2019 | China | Threatened abortion | 30/30; NR | 30/30; NR | 27±5;26±6/ 不孕年 4.2±2.6;4.7±2.4(yr) | Catgut embedding(BL 17, BL 18, BL 23, BL 20, BL 21, SP10, SP 8, KI 7, once every two weeks, 6 times + intramuscular injection of progesterone | Intramuscular injection of progesterone,40mg,once a day | 1) Level of serum human chorionic gonadotropin (HCG) 2) Estradiol (E2) 3) Progesterone (P) 4) TCM syndrome score | NR | pregnancy, the hormone levels in the observation group were superior to those in the control group (all P＜0.05). After treatment, the early abortion rate was 16.7% (5/30) in the observation group, which was lower than 33.3% (10/30) in the control group (P＜0.01); the pregnancy rate was 96.0% (24/25) in the observation group, which was higher than 80.0% (16/20) in the control group (P＜0.01). |
| O00-O99 Pregnancy, childbirth and the puerperium | Wu(4) | 2019 | China | Threatened abortion in early pregnancy complicated with subchorionic hematoma | 40/40; NR | 40/40; NR | 32±7;31±7/ 怀孕周期 56.2±11.5;57.1±10.9(w) 不孕年限 3.0±1.1;2.8±1.0(yr) | Auricular acupunctureTF5, AT4, CO10, CO15, CO12, AH6a, CO18, every 3 days with 1 day break, 3 weeks + Dydrogesterone | Dydrogesterone, 10mg/time, twice a day, 12weeks | 1) The percentage of helper T lymphocyte 2) Inhibitory T lymphocyte (Ts) 3) Ratio of Th and Ts 4) Serum level of CA125 | NR | Auricular acupuncture combined with dextroprogesterone can improve the effective rate of patients with threatened abortion in early pregnancy complicated with subchorionic hematoma, regulate immune factors, promote the hematoma absorption, and has a better synergistic effect with dextroprogesterone. |
| O00-O99 Pregnancy, childbirth and the puerperium | Wu(6) | 2019 | China | In vitro Fertilization-Embryo Transfer | 33/33; NR | 33/33; NR | 31.76±4.26;33.73±5.40/ 3.76±3.00;3.33±2.19 | Electroacupuncture (EA, CV 3, CV 6, ST 29, SP 6, LI 4, 25 min, every 2 days, 3 menstrual cycles) | Placebo needle puncture | 1) Shen deficiency syndrome scores 2) Number of retrieved oocytes and fertilization, high-quality embryo and clinical pregnancy rates. 3) Follicular fluid granulosa cell expression of phosphatidylinositide 3-kinases (PI3K), serine-threonine kinase (Akt) and forkhead box O3 (Foxo3a) mRNA | No obvious adverse reactions | For infertile patients with Shen defificiency syndrome undergoing IVF, EA for tonifying Shen as an adjunct treatment may alleviate clinical symptoms and improve the high-quality embryo rate. The EA-induced mechanism may involve regulation of PI3K/Akt/Foxo3a expression in granulosa cells to improve the developmental microenvironment of oocytes and inhibit granulosa cell apoptosis, possibly contributing to the improved clinical pregnancy rate |
| O00-O99 Pregnancy, childbirth and the puerperium | Xiao | 2018 | China | Labor | 61/61; NR | 60/60; NR | 27.62 ± 2.86; 27.72 ± 2.60/ 274.55 ± 7.77; 275.60 ± 7.59 | Combined spinal–epidural analgesia (CSEA) + patientcontrolled epidural analgesia (PCEA) + electroacupuncture (EA LI4, PC6, ST36, SP6, HANS-200A, 25 min) | CSEA + PCEA | 1) VAS for labor Pain 2) Complications, use of oxytocin, durations of three stages, delivery mode, cord blood pH, neonatus Apgar score | NR | EA can help to reduce labor pain in CSEA with PCEA labor analgesia process, and may be able to reduce the complications. |
| R00-R99 Symptoms, signs and abnormal clinical and laboratory findings, NEC | Dong(3) | 2019 | China | Urinary incontinence after stroke | 56/56; (32/24; 28/28) | 56/56; (32/24; 28/28) | 75.4±10.2; 73.2±9.8/ nr | Pelvic floor muscle training + acupuncture(ST36, SP6, CV4, CV3, once a day, 1month) | Pelvic floor muscle training | 1) Clinical effective rate 2) Myoelectric potential 3) Urine leakage times, VLPP, MUCP 4) ICI-Q-SF 5) Quality of life | NR | Pelvic floor muscle training combined with acupuncture can increase the therapeutic effect, improve the urodynamic parameters and quality of life in stroke patients with urinary incontinence, so it is worthy of clinical popularization and application. |
| R00-R99 Symptoms, signs and abnormal clinical and laboratory findings, NEC | Gao(2) | 2020 | China | Persistent vegetative state | 25/25; NR | 24/23; (16/8; 13/10) | 46.2±7.5;44.9±6.9/ NR | Xiao's “xingnciofusu” needling + rouiine western medicin Baihui (GV20) , Dingshen (Extra) to Shangen (Extra) (penetrating technique) , Fengchi (GB20) to GB20 (penetrating technique) , Neiguan (PC6) to Waiguan (TE5) (penetrating technique) , Hegu (LI4) to Laogong (HT8) (penetrating technique) and Taichong (LR3) to Yongquan (KI1),once a day,10days/ course,3 courses. | Routine western medicine treatment: Dehydration, anti-infection, nourishment of brain cells, improvement of cerebral blood circulation and other drug treatments, and rehabilitation treatment, once a day, 10days/course, 3 courses. | 1) Coma recovery scale-revised (CRS-R) score 2) Modified Ashworth scale (MAS) score 3) Glasgow coma scale (GCS) | NR | Xiao's “xingnaofusu” needling can remarkably improve the central nerve function, promote the recovery of brain function and the motor function of limbs, reduce the width of the third ventricle and improve the clinical therapeutic effect of regaining consciousness in the patients with PVS. |
| R00-R99 Symptoms, signs and abnormal clinical and laboratory findings, NEC | Ghanbari, | 2019 | Iran | Fatigue in patients with cancer who underwent chemotherapy | 30/30/30; NR | 30/30/30; NR | 50.43± 15.03; 51.83± 12.8; 54.10± 15.47/ nr | 1) Acupressure(ST-36, LI-4, SP-6) 2) Sham pressure | No intervention | 1) Fatigue severity: Visual Analog Scale | NR | Results of this investigation showed that acupressure has short-term effectiveness on the cancer-related fatigue of patients undergoing chemotherapy. |
| R00-R99 Symptoms, signs and abnormal clinical and laboratory findings, NEC | Huang | 2020 | China | Postoperative olfactory memory disorder and plasma melatonin | 20/20; (11/9; 10/10) | 20/20; (11/9; 10/10) | 39±4;41±4/ NR | Transcutaneous electrical acupoint stimulation (TEAS) Yingxiang (LI 20) and Yintang (GV29) | General anesthesia | 1) The changes of mean arterial pressure (MAP), heart rate (HR) and blood oxygen saturation (SpO2) 2) Smell identification score 3) The concentration of melatonin in plasma | NR | TEAS could improve the postoperative olfactory memory disorder in patients with general anesthesia of sevoflurane, and its mechanism may be related to the increase of plasma concentration of melatonin |
| R00-R99 Symptoms, signs and abnormal clinical and laboratory findings, NEC | Kamali | 2020 | Iran | Postoperative Nausea And Vomiting In Patients Undergoing Abdominal Hysterectomy | NR; NR | NR; NR | 49.9±7.4; 50.5±9.2/3.1±1.9;3.3±1.1 | 1) Ginger(1 g, orally before and after the anesthesia) 2) Dexmedmotidine(25 mg slowly injected before surgery) | 1) Vomiting scores and incidence of nausea in patients 2) Shivering incidence 3) Blood pressure 4) Mean heart rate | NR | Both dexmedmotidine and ginger are effective in reducing postoperative nausea and vomiting. But the effect of ginger is greater than that of dexmodetomidine. | |
| R00-R99 Symptoms, signs and abnormal clinical and laboratory findings, NEC | Karaman | 2019 | Turkey | Postoperative nausea and vomiting | 46/46/46/46; (14/32; 17/29; 16/30; 15/31) | 46/46/46/46; (14/32; 17/29; 16/30; 15/31) | 45;44;39;51/100;90;90;90 | 1) Lavender essential oil 2) Rose essential oil 3) Ginger essential oil, inhale its scent for 5 min | Placebo group | 1) Postoperative nausea and vomiting scores 2) Antiemetic medication requirement | NR | The aromatherapy can be used as an alternative or complementary method for managing PONV. Specifically, the ginger and lavender essential oils were superior to the rose oil and pure water for the aromatherapy treatments. However, further studies with larger sample sizes are necessary to confirm these results. |
| R00-R99 Symptoms, signs and abnormal clinical and laboratory findings, NEC | Li(3) | 2019 | China | Dysphagia in pseudobulbar palsy | 50/50; NR | 48;49; (29/19; 30/19) | 67.0±10.8; 67.1±10.5/ 41.1±38.6; 40.5±30.8 | Nape acupuncture + swallowing rehabilitation once per day, excluding weekends, over 8 weeks of treatment | Rehabilitative swallowing training, once per day, excluding weekends, 8 weeks | 1) Saliva-swallowing test 2) Water swallow test 3) Standardized swallowing assessment 4) Swallow quality-of-life questionnaire | None | Nape acupuncture combined with rehabilitative swallowing training has an effect on dysphagia caused by pseudobulbar palsy and improves quality of life. |
| R00-R99 Symptoms, signs and abnormal clinical and laboratory findings, NEC | Long | 2019 | China | Urinary retention | 40/40; (24/16; 22/18) | 40/40; (24/16; 22/18) | 40±11;39±9/ 7.7±5.2;7.1±5.7(yr) | Electroacupuncture(CV3, CV4, BL28, SP6, 30 min before operation) | Routine process-induced urination was given after operation | 1) The score of the first urination waiting time 2) The distension of lower abdomen on the evening of the postoperative 3) The first time urinary volume 4) Incidence of urinary retention | NR | Electroacupuncture preconditioning combined with induced urination can effectively prevent the incidence of urinary retention after milligan-morgan hemorrhoidectomy. |
| R00-R99 Symptoms, signs and abnormal clinical and laboratory findings, NEC | Martin | 2019 | USA | Postoperative nausea and vomiting after tonsillectomy in children. | 86/75; (41/45; 42/33) | 86/75; (41/45; 42/33) | 5.2 ± 1.9; 5.5 ± 1.8 / nr | Acupuncture at the P6 point + Usual antiemetics | Usual antiemetics | 1) Incidence of PONV | NR | Children receiving acupuncture plus antiemetic therapy had less risk of developing nausea during phase I and II recovery, but there was no difference in PONV on POD 1. Acupuncture may reduce nausea in the PACU, even when combined with antiemetics. |
| R00-R99 Symptoms, signs and abnormal clinical and laboratory findings, NEC | Varejão | 2019 | Brazil | Nausea and Vomiting in Pediatric Patients Undergoing Chemotherapy | 8/10; NR | 7/10; NR | 12.57 ± 2.57; 14.7 ± 2.11 | Laser acupuncture, 26 cycles | Placebo acupuncture | 1) Intensity of Nausea 2) Vomiting Episodes | None | The study concluded that laser acupuncture was effective in relieving nausea within 5 days of chemotherapy and in reducing the number of episodes of vomiting on Days 2 and 3 after chemotherapy. |
| R00-R99 Symptoms, signs and abnormal clinical and laboratory findings, NEC | Wang | 2020 | China | Post-stroke hand spasm | 35/35/35; NR | 33/33/34; (18/15; 17/16; 16/18) | 51±9; 52±9 ;53±10/ 64.8±38.2;68.9±39.4;61.9±32.89(d) | 1) Penetrating needling(LI 4, SI 3, TE 5, TE 9, 30min, once a day, 6 times/week, 2 weeks/course, 2 course) 2) (1) +(3) | 3) Kinesiotherapy | 1) Hand spasm index 2) Hand-wrist motor function 3) Activity of daily living | NR | Compared with the simple application of either penetrating acupuncture or kinesiotherapy, the combined treatment of them achieves the significant improvements in hand spasm degree, hand wrist motor function and ADL in patients with stroke. |
| R00-R99 Symptoms, signs and abnormal clinical and laboratory findings, NEC | Wang(4) | 2019 | China | Vomiting | 50/50/50; NR | 49/44/47; (31/18; 30/14; 26/21) | 53±6;55±7;53±7/ NR | 1) Acupuncture(ST 36, CV 12, PC 6, 30 min before chemotherapy, 3 days) + Tropisetron hydrochloride, 30 min before chemotherapy 2) Acupuncture(ST 36, CV 12, PC 6, 30 min after chemotherapy, 3 days) + Tropisetron hydrochloride(30 min before chemotherapy) | C) 30 min before chemotherapy, tropisetron hydrochloride, 5mg/times, once a day, 3days | 1) Digestive reaction score 2) Karnofsky performance status scale score 3) White blood cell count | NR | Acupuncture combined with the slow intravenous injection with tropisetron hydrochloride achieve the satisfactory effect of prevention and treatment for vomiting induced by chemotherapy of lung cancer. The acupuncture intervention before chemotherapy greatly improves the effect on the nausea and vomiting induced by chemotherapy of lung cancer. |
| R00-R99 Symptoms, signs and abnormal clinical and laboratory findings, NEC | Wang(7) | 2019 | China | Advanced cancer-relate d anorexia | 30/30; (17/13; 14/16) | 30/30; (17/13; 14/16) | 58.7 ±10.2; 54.6 + 6.5 / nr | Acupuncture(CV12, CV10, CV6, CV4, ST 24, ST26, 5 times/w, 2w) + megestrol acetate(1T, qd, 2w | Megestrol acetate tablet, qd, 2w | 1) The appetite visual analog scale (VAS) 2) Karnofsky (KPS) score 3) Body weight | 2 patients in intervention group: acupuncture local subcutaneous hemorrhage, which did not affect the subsequen treatmen | Abdominal acupuncture combined with oral megestrol acetate and oral megestrol acetate both can effectively improve the appetite and functional status of patients with advanced cancer-related anorexia. Abdominal acupuncture can improve the curative effect, which is better than that of western medication alone, providing a new idea for the treatment of advanced cancer-related anorexia in the future. |
| R00-R99 Symptoms, signs and abnormal clinical and laboratory findings, NEC | Yu | 2019 | China | Nausea and vomiting | 31/33/30 | 31/33/30; NR | 32±5;33±6;32±6/ NR | 1) Bilateral acupuncture point injection(PC6, 0.9％ sodium chloride 3ml + intravenous granisetron 3mg)(C) | 2) Bilateral PC6 sham injection of 0.9％ sodium chloride 3ml + intravenous granisetron 3mg(A) 3) Bilateral acupuncture point injection at PC6 of 0.9％sodium chloride 3ml +intravenous 0．9％sodium chloride 3ml(B) | 1) Visual analogue scales(nausea visual analog scale, NVAS) 2) The time of the first anal exsufflation and the Pain 24 hours after the operation 3) The dose and the related frequency of antiemetic drugs for rescue | NR | Either intravenous granisetron or acupuncture point injection at PC6 of O．9％sodium chloride can effectively reduce the incidence of posto[1erative nausea and vomiting after gynecological laparoscopic surgery．Intravenous granisetron combined with acupuncture point injection at PC6 of 0．9％sodium chloride has better effect and promotes the first anal exsufflation time,which is conducive to the rapid postoperative recovery of patients． |
| R00-R99 Symptoms, signs and abnormal clinical and laboratory findings, NEC | Zhuang | 2019 | China | Lower extremity surgery patients | 20/20; (14/6; 12/8) | 20/20; (14/6; 12/8) | 45.8±13.2;44.9±13.4/ NR | Transcutaneous electrical acupoint stimulation (ST36, SP6), 30 min before surgery to the end of surgery | Sham transcutaneous electrical acupoint stimulation (TEAS) -at the same acupoints with minimum current intensity | 1) Mean arterial pressure(MAP) 2) Heart rate 3) Blood gas analyze 4) Plasma SOD activity 5) MDA content | NR | TEAS at ST36 and SP6 can improve pulmonary function and attenuate oxidative stress response in patients using tourniquet after lower extremity surgery. |
| S00-T98 Injury, poisoning and certain other consequences of external causes | Bao | 2020 | China | Severe craniocerebral trauma patients with vegetative state | 50/50; (43/7; 42/8) | 50/50; (43/7; 42/8) | 43±16;45±15/ 24.3±11.8 ;30.6±16.8 (d) | Midnight-noon ebb-flow acupuncture(30 min, once a day, 5 times /week)+rehabilitation therapy (30 min each time, once a day) | Rehabilitation therapy(30 min each time, once a day) | 1) Scores of Glasgow coma scale (GCS) 2) Coma recovery scale-revised (CRS-R) 3) Conscious rate | NR | Midnight-noon ebb-flow acupuncture combined with rehabilitation therapy can effectively treat the severe craniocerebral trauma patients with vegetative state, improve the consciousness level, and have superior therapeutic effect compared with simple rehabilitation therapy. |
| S00-T98 Injury, poisoning and certain other consequences of external causes | Ding | 2020 | China | Anterior cruciate ligament reconstruction | 70/70; NR | 58/65; (34/24; 39/26) | 39±2;38±3/ 17.5±3.6;16.9±2.1 (d) | Electroacupuncture(GB 31, (ST 32,ST 36, ST 37, ST 40, GB 39, SP 8, SP 6, 20-30 min, twice a day, 7 days) | Routine rehabilitation treatment | 1) Wwelling degree (d) 2) Pain visual analogue scale (VAS) 3) Knee joint range of motion (ROM) 4) Scores of International Knee 5) Documentation Committee (IKDC) subjective short form 6) Scores of Lysholm | NR | EA combined with routine rehabilitation training could obviously reduce the pain of knee joint, improve the swelling degree, increase the ROM of knee joint, promote the functional recovery in patients with ACL reconstruction, which are superior to rehabilitation training alone. |
| S00-T98 Injury, poisoning and certain other consequences of external causes | Huang(2) | 2020 | Taiwan | Acute Brain Injury | 23/18; (14/9; 10/8) | 23/11; NR | 57±18;59±20/NR | Conventional neurologic intensive care + Wendan decoction (WDD), tid, initiated within 14 days and lasted >1 month | Conventional neurologic intensive care | 1) Duration of ventilator use 2) Intensive care unit stays 3) Glasgow Coma Scale (GCS) scores 4) Motor response 5) The best muscle power 6) Disability rating scale (DRS) scores 7) Modified Rankin scale (mRS) scores 8) The mortality rate for the first month 9) Barthel index (BI) scores 6 months later. | NR | In the early stages of acute brain injury, combination treatment with WDD was found to be safe. Furthermore, this treatment may improve neurologic functional outcomes after 6 months. |
| S00-T98 Injury, poisoning and certain other consequences of external causes | Xu(2) | 2020 | China | Bone metabolism in patients with spinal cord injury | 30/30; (19/11; 22/8) | 30/30; (19/11; 22/8) | 42.53±10.03;44.07±7.59/68.10±5.94;72.10±10.54 | Osteoporosis treatment apparatus + electroacupuncture(bilateral GB 34, GB 39, once a day, 5 days/week, 8 weeks | Osteoporosis treat- ment apparatus | 1) Bone mineral density (BMD) 2) Bone gla-containing protein (BGP) 3) Serum alkaline phosphatase (ALP) 4) Procollagen type I C-peptide (PICP) 5) 25–hydroxy-vitamin D [25(OH)D] | In the observation group, 1 patient had a small amount of hematoma after acupuncture | The osteoporosis treatment apparatus can improve bone metabolism in SCI patients, and the curative effect can be enhanced when combined with electroacupuncture at foot- shaoyang acupoints |
| S00-T98 Injury, poisoning and certain other consequences of external causes | Lu | 2020 | China | Delayed encephalopathy of CO intoxication | 14/14; (5/8; 7/7) | 14/14; (5/8; 7/7) | 58.4±11.8;50.6±13.2/ 16.5±9.6;16.6±10.9(hrs) | “Xingnao Kaiqiao" needling technique + hyperbaric oxygen therapy Yintang [EX— HN3] , Shangxing [GV23] , Baihui [GV20] , Sishenchong [EX-HN],Fengchi [GB20] , Taichong [LR3],once a day,5days / week , 6weeks | Hyperbaric oxygen therapy,once a day,5days / week , 6weeks | 1) Average fD* value (fXD*) 2) Barthel index (Bl) score | NR | Acupuncture combined with HBO can significantly improve the low-perfusion of bilateraI semi-oval center and daily living ability in patients with DEACMP, being significantly superior to simple HBO therapy in the curative effect. |
| S00-T98 Injury, poisoning and certain other consequences of external causes | Luo(2) | 2019 | China | Coma of acute carbon monoxide poisoning | 18/18; (10/8; 12/6) | 18/18; (10/8; 12/6) | 37.28 ±14.92; 38.67 ± 13.17/ 4.39 ±1.30; 4.17 ±1.04 | Acupuncture(GV 20, GV 26, EX-HN1, GB20, LI 4, LR 3, KI 1, once a day, 2 weeks) + hyperbaric oxygen therapy (HBOT) | Simple HBOT, once a day, 2w | 1) Score of Glasgow Coma Scale (GCS) 2) Levels of serum interleukin-6 (IL-6) 3) Interleukin-8 (IL-8) 4) Brain-derived growth factor (BDNF) | NR | Acupuncture combined with HBOT achieves the superior effect of promoting resuscitation and the clinical therapeutic effects as compared with the simple HBOT. Such combined treatment reduces the levels of serum IL-6 and IL-8, increases the level of serum BDNF in ACMP patients, as well as plays the active role in the prevention from delayed encephalopathy after acute carbon monoxide poisoning. |
| U00-U99 Codes for special purposes | Hu | 2020 | China | COVID-19 | 142/142; (89/53; 102/40) | 142/142; (89/53; 102/40) | 50.4±15.2;51.8±14.8/NR | Lianhuaqingwen (LH) capsule, 4C, tid, 14d + usual treatment | Usual treatment | 1) Rate of symptom (fever, fatigue, coughing) recovery 2) Time to symptom recovery 3) The rate of and the time to the recovery of individual symptoms 4) The proportion of patients with improvement on chest computed tomography 5) The proportion of patients with clinical cure 6) The timing and rate of conversion of SARS-CoV-2 RNA assay | No serious adverse events were reported. | In light of the safety and effectiveness profiles, LH capsules could be considered to ameliorate clinical symptoms of Covid-19. |
| U00-U99 Codes for special purposes | Xiao | 2020 | China | COVID-19 | 95/94/94; (47/48 ; 58/36 ; 50/44) | 95/94/94; (47/48 ; 58/36 ; 50/44) | 54.31±11.63;54.58±13.76; 54.06±13.90/NR | 1) Huoxiang Zhengqi dropping pills(bid, 14d) and Lianhua Qingwen granules(tid, 14d) + western medicine 2) Linahua granules + western medicine, tid, 14d | Conventional medicine | 1) Symptom improvement and disappearance rate 2) Prognosis | NR | The use of Huoxiang Zhengqi dropping pills and Lianhua Qingwen granules combined with western medicine may have clinical advantages for COVID-19 patients in improving clinical symptoms, reducing utilization rate of anti-infective drugs, and improving patient prognosis, which could pave the way for the use of complementary medicine in treating this infection. |
| U00-U99 Codes for special purposes | Xiong(2) | 2020 | China | COVID-19 | 22/20; NR | 22/20; NR | 57.10±14.00;62.40±12.30/NR | Xuanfei Baidu Decoction (XBD) + conventional drug therapy, 1 week | Conventional medicine | 1) Disappearance rate of main symptoms (fever, cough, and fatigue) 2) Disappearance rate of secondary symptoms 3) The changes in white blood cells, lym-phocytes, C-reactive protein, and erythrocyte sedimentation rate. | No obvious adverse reactions were seen in patients taking Chi-nese medicine. | XBD combined with conventional medicine may significantly improve patient’s clinical symptoms, increase the number of white blood cells and lymphocytes to improve immunity, and also significantly reduce C-reactive protein and erythrocyte sedimentation rate to play an anti-inflammatory effect. However, it needs to be confirmed by a large sample study. |
| U00-U99 Codes for special purposes | Yu | 2020 | China | Mild Corona Virus Disease-19 | 148/147; (82/65; 89/59) | 148/147; (82/65; 89/59) | 48.27±9.56;47.25±8.67/ NR | Lianhua Qingwen granules + arbidol 6g, tid | Arbidol 0.2g, tid | 1) TCM symptom scores 2) White blood count (WBC) 3) Lymphocyte count (LYM) 4) C-reactive protein (CRP) 5) Procalcitonin (PCT) 6) Chest CT | NR | Lianhua Qingwen granules combined with arbidol can relieve the clinical symptoms, adjust the inflammatory factors, increase the curative effects and reduce the severe transfer rate. |
| V01-Y98 External causes of morbidity and mortality | Rahimi | 2019 | Iran | Endotracheal intubation in patients who were receiving anesthesia | 30/30; (21/9; 14/16) | 30/30; (21/9; 14/16) | 41.7 ± 13.9; 47.2 ± 10.9 /nr | Acupuncture(LV 3, LI 4) | Sham needles were placed 1 cm lateral toL V 3 and LI 4 points. | 1) Systolic blood pressure (SBP) 2) Diastolic blood pressure (DBP) 3) Mean arterial blood pressure (MAP) 4) Heart rate (HR) | NR | Although acupuncture could have a very–short-term effect that reduces BP during endotracheal intubation, hemodynamic changes might not be prevented during endotracheal intubation. |
| Z00-Z99 Factors influencing health status and contact with health services | Deng(3) | 2019 | USA | Pain management in patients undergoing hematopoietic stem cell transplantation | 31/32; NR | 29/31; NR | nr | True acupuncture (TA, PC6, ST36, KI3, SP6, LR3, HT7, and Ear Shen Men, GV20, Ex-HN3 at midline five days starting on the day after chemotherapy) | Sham acupuncture, five days starting on the day after chemotherapy | 1) MD Anderson Symptom Inventory (MDASI) 2) Use of Pain medications | NR | Acupuncture appears to significantly reduce the need for pain medications during HSCT and the number of post- HSCT opioid users among baseline opioid nonusers. It warrants further studies as an opioid-sparing intervention for pain in HSCT patients. |
| Z00-Z99 Factors influencing health status and contact with health services | Dharwal | 2020 | India | Hemodialysis | 35/35; NR | 35/35; NR | NR | Acupressure from i.e. toe of both foot followed by midway between the medial ends of the eyebrow, at the ulnar end of the transverse crease of wrist, at the midway between the tip of the medial malleolus on both legs and two points on the both sole of the foot(5 min for deep breathing exercise + 25 min for acupressure, 5 min/area) | No treatment | 1) Anxiety: DASS-42 | NR | Findings of this study concluded that Acupressure intervention given for 30 minutes at once was effective in reducing anxiety among patients undergoing hemodialysis. |
| Z00-Z99 Factors influencing health status and contact with health services | Karjalian | 2020 | Iran | Hemodialysis | 30/30/30; (15/15; 16/14; 13/17) | 30/30/30; (15/15; 16/14; 13/17) | 55.31±8.88;52.67±10.89;55±11.14/ 6.93±2.97;6.17±2.72;8.03±3.14 | 1) Acupressure(SP6, SP10, ST36, LI11, Symmetrical pressure for one minute, followed by three intermittent pressures on each point. The researcher applied a 4-kg pressure with the thumb) 2) Sham acupressure | 3) Routine care | 1) Hemodynamic parameters 2) Visual analog scale 3) First analgesic requirement 4) Total amount of analgesic requirement 5) Nausea-vomiting 6) Necessity for antiemetic medication | No side-effects were reported by the patients during the study. | Acupressure can improve the severity of pruritus dramatically in hemodialysis patients. It can also reduce serum phosphorus and parathyroid hormone levels, which affect pruritus, significantly. Therefore, this simple and inexpensive intervention may be recommended for reducing uremic pruritus among patients undergoing hemodialysis. |
| Z00-Z99 Factors influencing health status and contact with health services | Kusuma | 2019 | Indonesia | In vitro fertilization | 12/12; NR | 12/12; NR | 35.00 ± 2,79; 34.33 ± 3.72/ 6.12 ± 3.64; 4.91 ± 3.34 | Electroacupuncture(verum-EA, GV20, MAIC 3, CV 4, CV 3, EX-CA 1, ST 36, BL 57, SP 6, KI 3, 2 times/week, before COS 4 times while each patient underwent a COS antagonistic protocol) | Sham-EA | 1) Oocyte maturation; rate of fertilization 2) Granulosa-cell apoptosis 3) Levels of growth-differentiation factor 9 (GDF9) 4) Bone-morphogenetic protein 15 (BMP15) | NR | EA can enhance oocyte maturation and fertilization rate, and reduce the granulosa-cell apoptosis index in an IVF program. |
| Z00-Z99 Factors influencing health status and contact with health services | Liu(4) | 2020 | China | Gastrointestinal and immune functions of elderly bedridden patients | 50/50; (23/27; 29/21) | 50/50; (23/27; 29/21) | 70.1±8.4;71.3±9.5/NR | Limb functional exercise + Chinese medicine acupoint massage | Limb functional exercise | 1) Immune function index 2) Gastrointestinal symptom score 3) Quality of life score 4) Perioperative stress injury 5) Patient satisfaction | The occurrence of common complications during hospitalization was observed. There was no significant difference in the incidence of adverse reactions between the two groups | Limb functional exercises combined with Chinese medicine acupoint massage can significantly improve gastrointestinal function, nursing satisfaction, and the quality of life of elderly bedridden patients during hospitalization, and can significantly improve the patients’ immune function. The immune function improvement may be related to the gastrointestinal function improvement. |
| Z00-Z99 Factors influencing health status and contact with health services | Noll | 2019 | USA | Postoperative quality of recovery | 55/53/55; NR | 54/53/54; (25/29; 24/29; 27/27) | 60.5 ± 11.5; 63.0 ± 11.9; 61.7 ± 9.5 / nr | 1) Acupressure therapy acupoints(PC6, LI4 and HT7, 2 min/acupoint), three times a day after surgery for a maximum of 2 postoperative days 2) Sham acupressure | No intervention | 1) QoR: QoR-15 questionnaire 2) Patients’ satisfaction 3) Postoperative nausea & vomiting 4) Pain score 5) Opioid (morphine equivalent) consumption. | NR | Two days of postoperative acupressure therapy (up to six treatments) did not significantly improve patient QoR, postoperative nausea and vomiting, pain score or opioid consumption. Acupressure, however, was associated with improved patient satisfaction. |
| Z00-Z99 Factors influencing health status and contact with health services | Tao | 2019 | China | Knee arthroplasty | 40/40; (23/17; 21/19) | 40/40; (23/17; 21/19) | 71±11;68±10/ NR | Electroacupuncture (LI 4, CV 6, CV 12, BL 20, BL 23), once every other day | Basis of the treatment | 1) Fasting blood glucose 2) Fasting insulin 3) Insulin resistance index | NR | Combined spinal and epidural anesthesia and postoperative epidural analgesia can improve short-term insulin resistance. Combined with EA, the improvement of insulin resistance is more obviously and longer. |
| Z00-Z99 Factors influencing health status and contact with health services | Yang(2) | 2019 | China | Postpartum rehabilitation | 60/60; NR | 60/60; NR | 28±3;28±3/ NR | Auricular acupuncture(TF5, TF4, AH6a, AT4, TF2, CO13, CO4, 30 min, 3 times/day, 5 days) + routine treatment | Routine treatment(Antibiotics, fluid replacement and maintaining water and electrolyte balance) | 1) Postpartum Pain 2) Anus exhaust time 3) Incidence of postpartum hemorrhage 4) Urinary retention 5) Constipation 6) Postpartum average hospitalization day | NR | Auricular acupuncture can effectively relieve postpartum pain in primipara with cesarean, promote postpartum exhaust and shorten hospitalization days, and reduce the incidence of postpartum complications such as postpartum hemorrhage, urinary retention and constipation, it is conducive to postpartum rehabilitation. |
| Comorbid or Concurrent Diseases with Different Major Classifications (KCD Code) | Huang | 2019 | China | Depression and chronic diarrhea | 56/48; NR | 56/48; NR | nr | Electroacupuncture(Baihui point, Sanyinjiao point and Yanglingquan point, 50 mm acupuncture needles, 30min/day) + probiotics(1.5 g/time, 3 times/day) | Trimebutine maleate tablets (100 mg/time, tid) + meptintin (100 mg/day, and the dose was adjusted according to the patient's condition and side effects) | 1) Hamilton Depression Rating Scale (HAM-D) score 2) Intestinal flora 3) Effects of the cell (inflammatory cytokines interleukins), tumor necrosis factor-α) 4) NE level 5) Brain-derived neurotrophic factor 6) Efficacy on chronic diarrhea | NR | The overall efficacy of the observation group was superior to that of the control group, showing a statistical difference. Electroacupuncture combined with probiotics brings good efficacy to patients with depression and chronic diarrhea, which is worthy of clinical promotion and development |
| Comorbid or Concurrent Diseases with Different Major Classifications (KCD Code) | Zhu | 2019 | China | Hypertension complicated with hyperlipidemia | 30/30/30; (18/12; 14/16; 19/11) | 30/30/30; (18/12; 14/16; 19/11) | 43.7±4.8;44.2±4.4;45.2±4.5/NR | 1) Huanglian lipid-lowering mixture + conventional treatment(once daily, 2 months) 2) Captopril capsules(12.5 mg, once daily in the morning, 2 months) + conventional treatment 3) Fluvastatin capsules(40 mg, once daily in the morning, 2 months) + conventional treatment | 1) Fasting TG, TC, LDL, HDL, and mean arterial pressure (MAP) 2) General information and adverse reactions. | Huanglian lipid-lowering mixture will not increase adverse reactions | Huanglian lipid-lowering mixture can effectively reduce TG, TC, LDL, and MAP levels, as well as improve HDL levels, providing a basis for clinical treatment of hypertension complicated with hyperlipidemia. |
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